Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Joana F, Neves"'
Autor:
Jonathan W. Lo, Jan-Hendrik Schroeder, Luke B. Roberts, Rami Mohamed, Domenico Cozzetto, Gordon Beattie, Omer S. Omer, Ellen M. Ross, Frank Heuts, Geraldine M. Jowett, Emily Read, Matthew Madgwick, Joana F. Neves, Tamas Korcsmaros, Richard G. Jenner, Lucy S. K. Walker, Nick Powell, Graham M. Lord
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The maintenance of intestinal homeostasis is a fundamental process critical for organismal integrity. Sitting at the interface of the gut microbiome and mucosal immunity, adaptive and innate lymphoid populations regulate the balance between
Externí odkaz:
https://doaj.org/article/9c1706884f1e46cd8fa10a092e27a500
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract The intestine performs functions central to human health by breaking down food and absorbing nutrients while maintaining a selective barrier against the intestinal microbiome. Key to this barrier function are the combined efforts of lumen‐
Externí odkaz:
https://doaj.org/article/074d909e776948108099e1117b1dc14d
Autor:
Jan-Hendrik Schroeder, Gordon Beattie, Jonathan W. Lo, Tomasz Zabinski, Nick Powell, Joana F. Neves, Richard G. Jenner, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Huge progress has been made in understanding the biology of innate lymphoid cells (ILC) by adopting several well-known concepts in T cell biology. As such, flow cytometry gating strategies and markers, such as CD90, have been applied to indentify ILC
Externí odkaz:
https://doaj.org/article/51f45fc4faa84fa3900e89aef90a55fc
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammatory bowel disease (IBD) is an idiopathic condition characterized by chronic relapsing inflammation in the intestine. While the precise etiology of IBD remains unknown, genetics, the gut microbiome, environmental factors, and the immune syste
Externí odkaz:
https://doaj.org/article/56d429f6a7bd40eaaf01c2c7c07d6dff
Autor:
Jan-Hendrik Schroeder, Luke B. Roberts, Katrin Meissl, Jonathan W. Lo, Dominika Hromadová, Kelly Hayes, Tomasz Zabinski, Emily Read, Catarina Moreira Heliodoro, Rita Reis, Jane K. Howard, Richard K. Grencis, Joana F. Neves, Birgit Strobl, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Innate lymphoid cells (ILC) play a significant role in the intestinal immune response and T-bet+ CD127+ group 1 cells (ILC1) have been linked to the pathogenesis of human inflammatory bowel disease (IBD). However, the functional importance of ILC1 in
Externí odkaz:
https://doaj.org/article/5e18d42e0aa843848e7f5977f4051c1e
Autor:
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadová, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD). However, a
Externí odkaz:
https://doaj.org/article/ba9f9bb4005040f781058400f748fa39
Autor:
Inês Sequeira, Joana F. Neves, Dido Carrero, Qi Peng, Natalia Palasz, Kifayathullah Liakath-Ali, Graham M. Lord, Peter R. Morgan, Giovanna Lombardi, Fiona M. Watt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Keratin 76 (Krt76) is an epithelial differentiation marker that is downregulated in oral squamous cell carcinomas, correlating with poor prognosis. Here the authors show that genetic ablation of Krt76 in a mouse model results in increased susceptibil
Externí odkaz:
https://doaj.org/article/2887a9969f3b4463a91cb5977cdb295e
Autor:
Geraldine M. Jowett, Joana F. Neves
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/b621f549a9624fbd9e39b5bc8edc7b2b
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 18:731-742
Over the past two decades, the importance of the microbiota in health and disease has become evident. Pathological changes to the oral bacterial microbiota, such as those occurring during periodontal disease, are associated with multiple inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9203261cde0f801403c20f81f50b79a
https://doi.org/10.1038/s41575-021-00488-4
https://doi.org/10.1038/s41575-021-00488-4
Publikováno v:
Development (Cambridge, England). 149(8)
The traditional view of immune cells is that their role within the body is to combat infections; however, it is becoming increasingly clear that they also perform tasks that are not classically associated with inflammation and pathogen clearance. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8307720a958a54b0a727915f51aa7103
https://pubmed.ncbi.nlm.nih.gov/35502785
https://pubmed.ncbi.nlm.nih.gov/35502785