Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Joana D. Amaral"'
Autor:
Joana Gonçalves, Joana D. Amaral, Rita Capela, Maria de Jesus Perry, Cláudia Braga, Maria Manuela Gaspar, Fátima M. Piedade, Lubertus Bijlsma, Antoni Roig, Sandra N. Pinto, Rui Moreira, Pedro Florindo, Cecília M. P. Rodrigues
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have received relatively litt
Externí odkaz:
https://doaj.org/article/cfb9a99efa384c4998ddab96fc03402d
Autor:
Ana S. André, Joana N. R. Dias, Sandra I. Aguiar, Ana Leonardo, Sara Nogueira, Joana D. Amaral, Célia Fernandes, Lurdes Gano, João D. G. Correia, Marco Cavaco, Vera Neves, Jorge Correia, Miguel Castanho, Cecília M. P. Rodrigues, Maria Manuela Gaspar, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionCancer is a major public health problem with over 19 million cases reported in 2020. Similarly to humans, dogs are also largely affected by cancer, with non-Hodgkin's lymphoma (NHL) among the most common cancers in both species. Comparati
Externí odkaz:
https://doaj.org/article/e1ae62f371ba4be582f085b5e995f720
Autor:
Jacinta O. Pinho, Mariana Matias, Vanda Marques, Carla Eleutério, Célia Fernandes, Lurdes Gano, Joana D. Amaral, Eduarda Mendes, Maria Jesus Perry, João Nuno Moreira, Gert Storm, Ana Paula Francisco, Cecília M.P. Rodrigues, M. Manuela Gaspar
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114021- (2023)
The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifical
Externí odkaz:
https://doaj.org/article/8bcb887236f344f381f68daa3c7e19f5
Autor:
Sara R. Oliveira, Pedro A. Dionísio, Maria M. Gaspar, Leonor Correia Guedes, Miguel Coelho, Mário M. Rosa, Joaquim J. Ferreira, Joana D. Amaral, Cecília M. P. Rodrigues
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Parkinson’s disease (PD) is mainly driven by dopaminergic neuronal degeneration in the substantia nigra pars compacta accompanied by chronic neuroinflammation. Despite being mainly sporadic, approximately 10% of all cases are defined as heritable f
Externí odkaz:
https://doaj.org/article/b11d78ae04ff483fbbad1f0ab9210f7b
Autor:
Natália Aniceto, Vanda Marques, Joana D. Amaral, Patrícia A. Serra, Rui Moreira, Cecília M. P. Rodrigues, Rita C. Guedes
Publikováno v:
Molecules, Vol 27, Iss 15, p 4718 (2022)
Necroptosis has emerged as an exciting target in oncological, inflammatory, neurodegenerative, and autoimmune diseases, in addition to acute ischemic injuries. It is known to play a role in innate immune response, as well as in antiviral cellular res
Externí odkaz:
https://doaj.org/article/1b84936adb6a4f47a3b9debc9b99c2d7
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Externí odkaz:
https://doaj.org/article/7961c3a2e4664114aa0944ea7a7841ea
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Brain tumor, as any type of cancer, is assumed to be sustained by a small subpopulation of stem-like cells with distinctive properties that allow them to survive conventional therapies and drive tumor recurrence. Thus, the identification of new molec
Externí odkaz:
https://doaj.org/article/d7ade87fcafd4fcda47fd5c09111c3d6
Autor:
Sara R. Oliveira, Pedro A. Dionísio, Maria M. Gaspar, Maria B. T. Ferreira, Catarina A. B. Rodrigues, Rita G. Pereira, Mónica S. Estevão, Maria J. Perry, Rui Moreira, Carlos A. M. Afonso, Joana D. Amaral, Cecília M. P. Rodrigues
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5289 (2021)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-indepe
Externí odkaz:
https://doaj.org/article/dfc4e03c53f9497a8575c4e31b255f03
Autor:
Sara R. Oliveira, Pedro A. Dionísio, Leonor Correia Guedes, Nilza Gonçalves, Miguel Coelho, Mário M. Rosa, Joana D. Amaral, Joaquim J. Ferreira, Cecília M. P. Rodrigues
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 945 (2020)
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, being largely characterized by motor features. MicroRNAs (miRNAs) are small non-coding RNAs, whose deregulation has been associated with neurodegeneration in PD
Externí odkaz:
https://doaj.org/article/03542091e0604edfbbcfced402488f1d
Autor:
Joana D. Amaral, Ricardo J.S. Viana, Rita M. Ramalho, Clifford J. Steer, Cecília M.P. Rodrigues
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1721-1734 (2009)
Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several
Externí odkaz:
https://doaj.org/article/74b78e9f01d243969354f043629798fe