Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells

Autor: Joana D’Arc Campeiro, Wendy A. Dam, Mirian A. F. Hayashi, Jacob van den Born

Publikováno v: Pharmaceutics, Vol 15, Iss 6, p 1576 (2023)

Proteinuria drives progressive tubulointerstitial fibrosis in native and transplanted kidneys, mainly through the activation of proximal tubular epithelial cells (PTECs). During proteinuria, PTEC syndecan-1 functions as a docking platform for properd

Externí odkaz: https://doaj.org/article/4579805a42a94424bd6951c7b3fe2b61

Impact of Reck expression and promoter activity in neuronal in vitro differentiation

Autor: Mari Cleide Sogayar, Sheila M.B. Winnischofer, Ricardo Cesar Cintra, Joana D'Arc Campeiro, Isis C C Nascimento, Mirian A. F. Hayashi, Juliano R. Guerreiro, Thais Assis-Ribas, Henning Ulrich, Maria Trombetta-Lima

Publikováno v: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Reck (REversion-inducing Cysteine-rich protein with Kazal motifs) tumor suppressor gene encodes a multifunctional glycoprotein which inhibits the activity of several matrix metalloproteinases (MMPs), and has the ability to modulate the Notch and cano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632aef52eba39cba8f82eac64786d203
https://doi.org/10.1007/s11033-021-06175-6

A Native CPP from Rattlesnake with Therapeutic and Theranostic Properties

Autor: Lucas Carvalho Porta, Joana D'Arc Campeiro, Mirian A. F. Hayashi

Publikováno v: Methods in Molecular Biology ISBN: 9781071617519

The cell-penetrating peptides (CPPs) are characterized by the ability of internalization into cells in vitro and in vivo, and the ability of these peptides can rely on a high content of positive charges, as it is the case of the native CPP crotamine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd7f67fc50e8d164829de3c448d8d081
https://doi.org/10.1007/978-1-0716-1752-6_6

In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine

Autor: Giovanna B. Papa, Lucas Carvalho Porta, Tiago Rodrigues, Rosely Oliveira Godinho, Mirian A. F. Hayashi, Joana D'Arc Campeiro, Eduardo B. Oliveira

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 185

Crotamine is a cationic polypeptide composed by 42 amino acid residues with several pharmacological and biological properties, including the selective ability to enter and kill actively proliferating tumour cells, which led us to propose its use as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d992cbf21550917899df080c6f50bcd
https://pubmed.ncbi.nlm.nih.gov/32621838

Crotamine induces browning of adipose tissue and increases energy expenditure in mice

Autor: Marcelo Paradiso Marinovic, Sunamita de Carvalho Lima, Joana D'Arc Campeiro, Marcela B. Nering, Eduardo B. Oliveira, Andréa L. Rocha, Marcelo A. Mori, Mirian A. F. Hayashi

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

Crotamine, originally isolated from rattlesnake venom, has been extensively studied due to its pleiotropic biological properties, and special attention has been paid to its antitumor activity. However, long-term treatment with crotamine was accompani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6460b34d2dd939aef87880ce5ef3f5
http://link.springer.com/article/10.1038/s41598-018-22988-1