Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Joana C. Silva"'
Autor:
Bing Guo, Victor Borda, Roland Laboulaye, Michele D. Spring, Mariusz Wojnarski, Brian A. Vesely, Joana C. Silva, Norman C. Waters, Timothy D. O’Connor, Shannon Takala-Harrison
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Malaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based esti
Externí odkaz:
https://doaj.org/article/7cae15b4cbd74ccc81153c6622534127
Autor:
Gail E. Potter, Viviane Callier, Biraj Shrestha, Sudhaunshu Joshi, Ankit Dwivedi, Joana C. Silva, Matthew B. Laurens, Dean A. Follmann, Gregory A. Deye
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-17 (2023)
Abstract Background Early phase malaria vaccine field trials typically measure malaria infection by PCR or thick blood smear microscopy performed on serially sampled blood. Vaccine efficacy (VE) is the proportion reduction in an endpoint due to vacci
Externí odkaz:
https://doaj.org/article/053e346859e2446086ce6e39b53fa97f
Autor:
Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, Stephen L. Hoffman
Publikováno v:
Expert Review of Vaccines, Vol 0, Iss 0 (2023)
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especi
Externí odkaz:
https://doaj.org/article/64ccc130995e4fbda0570808ef7ca47d
Autor:
Wilson Tavares, Joana Morais, José F. Martins, Ryan J. Scalsky, Thomas C. Stabler, Márcia M. Medeiros, Filomeno J. Fortes, Ana Paula Arez, Joana C. Silva
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Over the past two decades, a considerable expansion of malaria interventions has occurred at the national level in Angola, together with cross-border initiatives and regional efforts in southern Africa. Currently, Angola aims to consolidate
Externí odkaz:
https://doaj.org/article/1658d75985784fe48dc9cb1be3c659bf
Autor:
Diana Moita, Teresa G. Maia, Miguel Duarte, Carolina M. Andrade, Inês S. Albuquerque, Ankit Dwivedi, Joana C. Silva, Lilia González-Céron, Chris J. Janse, António M. Mendes, Miguel Prudêncio
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Two malaria parasite species, Plasmodium falciparum (Pf) and P. vivax (Pv) are responsible for most of the disease burden caused by malaria. Vaccine development against this disease has focused mainly on Pf. Whole-sporozoite (WSp) vaccinatio
Externí odkaz:
https://doaj.org/article/e826d5ba7493466aa874bf76000cc79f
Autor:
Thomas C. Stabler, Ankit Dwivedi, Biraj Shrestha, Sudhaunshu Joshi, Tobias Schindler, Amed Ouattara, Guillermo A. García, Claudia Daubenberger, Joana C. Silva
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-17 (2022)
Abstract Background The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most comm
Externí odkaz:
https://doaj.org/article/7f04ab0869a14203a0550948bbf8e570
Autor:
Gillian Mbambo, Ankit Dwivedi, Olukemi O. Ifeonu, James B. Munro, Biraj Shrestha, Robin E. Bromley, Theresa Hodges, Ricky S. Adkins, Bourema Kouriba, Issa Diarra, Amadou Niangaly, Abdoulaye K. Kone, Drissa Coulibaly, Karim Traore, Amagana Dolo, Mahamadou A. Thera, Matthew B. Laurens, Ogobara K. Doumbo, Christopher V. Plowe, Andrea A. Berry, Mark Travassos, Kirsten E. Lyke, Joana C. Silva
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHost gene and protein expression impact susceptibility to clinical malaria, but the balance of immune cell populations, cytokines and genes that contributes to protection, remains incompletely understood. Little is known about the determi
Externí odkaz:
https://doaj.org/article/4be637d5b54b4a7cbb6926e457c1deca
Autor:
Joana C. Silva, Ankit Dwivedi, Kara A. Moser, Mahamadou S. Sissoko, Judith E. Epstein, Sara A. Healy, Kirsten E. Lyke, Benjamin Mordmüller, Peter G. Kremsner, Patrick E. Duffy, Tooba Murshedkar, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here the authors show that controlled human malaria infection with a Brazilian parasite highly divergent from vaccine and West African field strains can provide estimates of vaccine efficacy in Mali, and could replace field testing, streamlining vacc
Externí odkaz:
https://doaj.org/article/8adef3faef374367ad0d7275f5f65245
Autor:
Albert E. Zhou, Zalak V. Shah, Katie R. Bradwell, James B. Munro, Andrea A. Berry, David Serre, Shannon Takala-Harrison, Timothy D. O’Connor, Joana C. Silva, Mark A. Travassos
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background RIFINs and STEVORs are variant surface antigens expressed by P. falciparum that play roles in severe malaria pathogenesis and immune evasion. These two highly diverse multigene families feature multiple paralogs, making their clas
Externí odkaz:
https://doaj.org/article/d36a18d5a84e4f59b695a9c277819f2e
Autor:
Jonathan G. Lawton, Albert E. Zhou, Drissa Coulibaly, Emily M. Stucke, Antoine Dara, Matthew B. Laurens, Joana C. Silva, Mahamadou A. Thera, Mark A. Travassos
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 81-82 (2023)
OBJECTIVES/GOALS: Recent in vitro evidence suggests that diverse parasite protein families called RIFINs and STEVORs are displayed on the surface of infected red blood cells and may have a role in severe malaria, but they remain sparsely studied in n
Externí odkaz:
https://doaj.org/article/01c509ba0cd941b6bc01a21ddbd771b1