Výsledky vyhledávání - "Joana Augusto"

Akademický článek

AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome

Autor: Aoife Campbell, Gareth Morris, Albert Sanfeliu, Joana Augusto, Elena Langa, Jaideep C. Kesavan, Ngoc T. Nguyen, Ronan M. Conroy, Jesper Worm, Lukasz Kielpinski, Mads Aaboe Jensen, Meghan T. Miller, Thomas Kremer, Cristina R. Reschke, David C. Henshall

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 514-529 (2022)

Angelman syndrome (AS) is a severe neurodevelopmental disorder featuring ataxia, cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations or deletion of the maternal copy of the paternally imprinted UBE3A gene, with current precis

Externí odkaz: https://doaj.org/article/9cfd00cc33fa406da3ff7352a705c687

Zobrazit plný text záznamu

Exercise-induced modulation of neuroinflammation in ageing

Autor: Zsuzsanna Barad, Joana Augusto, Áine M. Kelly

Publikováno v: The Journal of physiologyReferences.

Optimal performance of the central nervous system (CNS) depends on dynamic, multidirectional communication between different cell types both within and without the CNS to maintain the homeostatic environment. Ageing, in turn, is associated with CNS d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb1056e278d187df123e38c3175eed0
https://pubmed.ncbi.nlm.nih.gov/36479905

Zobrazit plný text záznamu

Preeclampsia risk in oocyte donation versus double gamete donation pregnancies: A systematic review and meta-analysis

Autor: Joana Augusto, Ana Margarida Póvoa

Publikováno v: European journal of obstetrics, gynecology, and reproductive biology. 276

The number of pregnancies achieved through gamete donation has escalated over the last decades. It has been hypothesized that double gamete donation pregnancies would have a higher risk of preeclampsia compared to single gamete donation pregnancies d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c6f662504b092a436f7cb87d545de8
https://pubmed.ncbi.nlm.nih.gov/35939910

Zobrazit plný text záznamu

Investigation of MicroRNA-134 as a Target against Seizures and SUDEP in a Mouse Model of Dravet Syndrome

Autor: Rogério R. Gerbatin, Joana Augusto, Gareth Morris, Aoife Campbell, Jesper Worm, Elena Langa, Cristina R. Reschke, David C. Henshall

Publikováno v: eNeuro. 9(5)

Dravet syndrome (DS) is a catastrophic form of pediatric epilepsy mainly caused by noninherited mutations in theSCN1Agene. DS patients suffer severe and life-threatening focal and generalized seizures which are often refractory to available anti-seiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc762e15097d70f1cedb8718b922eb6
https://pubmed.ncbi.nlm.nih.gov/36240080

Zobrazit plný text záznamu

Sexual dimorphism in epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the Scn1a gene

Autor: Rogério R. Gerbatin, David C. Henshall, Cristina R. Reschke, Halima Boutouil, Joana Augusto

ObjectiveDravet Syndrome (DS) is a catastrophic form of paediatric epilepsy associated with multiple comorbidities mainly caused by mutations in the SCN1A gene. DS progresses in three different phases termed febrile, worsening and stabilization stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbfd18a5bdad2558d05ea964cb858615
https://doi.org/10.1101/2021.08.27.457904

Zobrazit plný text záznamu

Life-span characterization of epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the Scn1a gene

Autor: Rogério R, Gerbatin, Joana, Augusto, Halima, Boutouil, Cristina R, Reschke, David C, Henshall

Publikováno v: Experimental Neurology. 354:114090

Dravet Syndrome (DS) is a catastrophic form of paediatric epilepsy associated with multiple comorbidities mainly caused by mutations in the SCN1A gene. DS progresses in three different phases termed febrile, worsening and stabilization stage. Mice th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405bfb367ad2e25c0aa095a44fa10f2c
https://doi.org/10.1016/j.expneurol.2022.114090

Zobrazit plný text záznamu