Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joana A Vidigal"'
Autor:
Carla P Concepcion, Yoon-Chi Han, Ping Mu, Ciro Bonetti, Evelyn Yao, Aleco D'Andrea, Joana A Vidigal, William P Maughan, Paul Ogrodowski, Andrea Ventura
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002797 (2012)
MicroRNAs belonging to the miR-34 family have been proposed as critical modulators of the p53 pathway and potential tumor suppressors in human cancers. To formally test these hypotheses, we have generated mice carrying targeted deletion of all three
Externí odkaz:
https://doaj.org/article/6caf9841ee7a4deeaf7f26377b954e8b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Off-target effects often confound the interpretation of CRISPR screens. Here, the authors introduce a computational method that corrects for off-targets in gRNA depletion assays, circumventing the need to completely discard unspecific guides.
Externí odkaz:
https://doaj.org/article/a61d9a2685ec4a239acd6ead2d346875
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 1, Pp 1-42 (2020)
Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein compl
Externí odkaz:
https://doaj.org/article/bae390359d534068ba217479ab9593c2
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/2c254d1109bf4d5aabffbec44b614c5e
Autor:
Laura Sala, Srividya Chandrasekhar, Rachel L. Cosby, Gaspare La Rocca, Todd S. Macfarlan, Parirokh Awasthi, Raj Chari, Michael Kruhlak, Joana A. Vidigal
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway with essential roles in development and disease. Yet, little is known about its regulation in vivo. Here, we show that in quiescent mouse splenocytes, AGO2 localizes almost exclusivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b0b33c06f002cce48027e66689a562
https://doi.org/10.1101/2022.07.17.500356
https://doi.org/10.1101/2022.07.17.500356
Autor:
Paul Ogrodowski, Andrea Ventura, Kevin M. Haigis, Xiaoyi Li, Tullia Lindsten, Gaspare La Rocca, Joana A. Vidigal, Kemal M. Akat, Thomas Tuschl, Minsi Zhang, Yilun Ma, Bing Shui, Gunter Meister, Bryan King, Craig B. Thompson, Vincenzo Cavalieri, Chiara Mastroleo, Kevin Chen, Doron Betel, Viviana Anelli
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ab5726f1dc1d809023e467dbe5e18c
http://hdl.handle.net/10447/518215
http://hdl.handle.net/10447/518215
Autor:
Craig B. Thompson, Vincenzo Cavalieri, Kevin Chen, Bryan King, Yilun Ma, Viviana Anelli, Joana A. Vidigal, Xiaoyi Li, Thomas Tuschl, Andrea Ventura, Gunter Meister, Tullia Lindsten, Minsi Zhang, Paul Ogrodowski, Doron Betel, Chiara Mastroleo, Bing Shui, Kemal M. Akat, Kevin M. Haigis, Gaspare La Rocca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc10265fd992a8c6d5535e8033e43dd0
https://doi.org/10.7554/elife.70948.sa2
https://doi.org/10.7554/elife.70948.sa2
Autor:
Yilun Ma, Bing Shui, Andrea Ventura, Tullia Lindsten, Joana A. Vidigal, Viviana Anelli, Kemal M. Akat, Doron Betel, Bryan King, Gaspare La Rocca, Gunter Meister, Chiara Mastroleo, Thomas Tuschl, Craig B. Thompson, Vincenzo Cavalieri, Kevin M. Haigis, Minsi Zhang, Kevin Chen, Paul Ogrodowski, Xiaoyi Li
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss of function experiments have provided key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b440e6b8b6353b0185751b14e93d843e
https://doi.org/10.1101/2021.06.01.445680
https://doi.org/10.1101/2021.06.01.445680
Off-target cleavage by Cas9 can confound measurements of cell proliferation/viability in CRISPR assays by eliciting a DNA-damage response that includes cell cycle arrest1-3. This gene-independent toxicity has been documented in large scale assays2-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a74ebde73eb90cc8b9ee36d0541af3d
https://doi.org/10.1101/809970
https://doi.org/10.1101/809970
Publikováno v:
Front Biosci (Landmark Ed)
Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce63cc9fe5e1767b898e2db158ea713d
https://pubmed.ncbi.nlm.nih.gov/31585876
https://pubmed.ncbi.nlm.nih.gov/31585876