Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joan Zugay-Murphy"'
Autor:
Keith W. Rickert, Kevin J. Lumb, Stephen M. Soisson, Sujata Sharma, Sangita B. Patel, Joan Zugay-Murphy, Lynn Miesel, Gina M. Clayton, Sheo B. Singh, Maria Kornienko, Srivanya Tummala, Daniel J. Klein, John C. Reid
Publikováno v:
Journal of Biological Chemistry. 288:34073-34080
The emergence of antibiotic-resistant strains of pathogenic bacteria is an increasing threat to global health that underscores an urgent need for an expanded antibacterial armamentarium. Gram-negative bacteria, such as Escherichia coli, have become i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff19316895ff386a9bcd452575bca64
https://doi.org/10.1074/jbc.m113.513028
https://doi.org/10.1074/jbc.m113.513028
Autor:
Ryan D. Otte, Sujata Sharma, Jongwon Lim, Hua-Poo Su, Lin Xu, Brandon M. Taoka, Grace Chan, C. Gary Marshall, Kerrie Spencer, Michael D. Altman, Christopher J. Dinsmore, Hong Yin, Craig Rosenstein, Jonathan R. Young, Joan Zugay-Murphy, Alexander A. Szewczak
Publikováno v:
Journal of Medicinal Chemistry. 54:7334-7349
The JAK-STAT pathway mediates signaling by cytokines, which control survival, proliferation, and differentiation of a variety of cells. In recent years, a single point mutation (V617F) in the tyrosine kinase JAK2 was found to be present with a high i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b226bd12a7b3aa4917ecba21eae00a9
https://doi.org/10.1021/jm200909u
https://doi.org/10.1021/jm200909u
Autor:
Marc Abrams, Laura Sepp-Lorenzino, Steve Stirdivant, Joan Zugay-Murphy, Keith W. Rickert, Xianzhi Mao, Stephen C. Beck, Mark E. Fraley, Robert M. Garbaccio, Rob Lobell, Youwei Yan, Bob Drakas, Paul Zuck, Sylvie Jezequel-Sur, Kelly Hamilton, Timothy J. Hartingh, Constantine Kreatsoulas, Edward S. Tasber, Sanjeev Munshi, Antonella Converso, Eileen S. Walsh, George D. Hartman, Carolyn A. Buser, Weikang Tao, V V Sardana
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1240-1244
A high throughput screening campaign was designed to identify allosteric inhibitors of Chk1 kinase by testing compounds at high concentration. Activity was then observed at K(m) for ATP and at near-physiological concentrations of ATP. This strategy l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a164d70b45a247a3957cdbd7608b23b
https://doi.org/10.1016/j.bmcl.2008.12.076
https://doi.org/10.1016/j.bmcl.2008.12.076
Autor:
Eileen S. Walsh, Steve Stirdivant, George D. Hartman, Kelly Hamilton, Marc Abrams, Robert M. Garbaccio, Laura Sepp-Lorenzino, Lawrence Kuo, Steve Beck, Joan Zugay Murphy, Constantine Kreatsoulas, Justin T. Steen, Sanjeev Munshi, Carolyn A. Buser, Weikang Tao, Shaei Huang, Youwei Yan, V V Sardana, Bob Drakas, Mari Ikuta, James Hardwick, Keith W. Rickert, Mark E. Fraley, Elizabeth Mahan, Xianzhi Mao, Rob Lobell, Michael Reilly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5907-5912
Through a comparison of X-ray co-crystallographic data for 1 and 2 in the Chek1 active site, it was hypothesized that the affinity of the indolylquinolinone series (2) for Chek1 kinase would be improved via C6 substitution into the hydrophobic region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9417e1526f4bd74048baad5244ad1fea
https://doi.org/10.1016/j.bmcl.2006.08.053
https://doi.org/10.1016/j.bmcl.2006.08.053
Autor:
Paul L. Darke, Sanjeev Munshi, Zhongguo Chen, Lawrence C. Kuo, Bei Xu, Joan Zugay-Murphy, V V Sardana, Mohinder K. Sardana
Publikováno v:
Protein Expression and Purification. 34:190-196
Expression and purification of human beta-secretase (BACE1) in bacteria have been plagued with issues concerning solubility, inhomogeneous N-terminus, and lack of enzymic activity. Several forms of the mature human BACE1 have been expressed in Escher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fea7d6e57b22fbf50f6e9846446fc23
https://doi.org/10.1016/j.pep.2003.12.014
https://doi.org/10.1016/j.pep.2003.12.014
Autor:
Colleen M. McDonough, Emilio A. Emini, Bruce D. Dorsey, Paul L. Darke, Mark Stahlhut, William A. Schleif, Stuart R. Michelson, I-W. Chen, David B. Olsen, Carrie A. Rutkowski, Joseph P. Vacca, Stacey L. McDaniel, Joan Zugay-Murphy, Rhonda B. Levin, Jiunn H. Lin, M. Katharine Holloway, Lawrence C. Kuo, Jacob M. Hoffman, Christina L. Newton, and Joel R. Huff
Publikováno v:
Journal of Medicinal Chemistry. 43:3386-3399
Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of acquired immune-deficiency syndrome (AIDS). However, the emergence of viral resistance, demanding treatment protocols, and adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b883bd7828f12a025a3e8342b3125a8
https://doi.org/10.1021/jm9903848
https://doi.org/10.1021/jm9903848
Autor:
Steven S. Carroll, Vinod Sardana, Zhucheng Yang, Amanda R. Jacobs, Christine Mizenko, Dawn Hall, Lorraine Hill, Joan Zugay-Murphy, Lawrence C. Kuo
Publikováno v:
Biochemistry. 39:8243-8249
The enzymatic activity of a C-terminally truncated form of the RNA-dependent RNA polymerase, termed NS5B(Delta21), of the hepatitis C virus (strain BK) has been investigated using both homopolymeric and heteropolymeric RNA templates. Incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2020f15874fa3cdd3f21bd028ed36dcf
https://doi.org/10.1021/bi991992s
https://doi.org/10.1021/bi991992s
Autor:
Lawrence C. Kuo, Abigail Wolfe, Emilio A. Emini, Ying Li, Bei Xu, Joan Zugay-Murphy, Peter J. Felock, Zhongguo Chen, Marc V. Witmer, Daria J. Hazuda, Sanjeev Munshi, Youwei Yan, V V Sardana
Publikováno v:
Journal of Molecular Biology. 296:521-533
The crystal structure of simian immunodeficiency virus (SIV) integrase that contains in a single polypeptide the core and the C-terminal deoxyoligonucleotide binding domain has been determined at 3 A resolution with an R -value of 0.203 in the space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a5c061dda24790ca652d37a70a191c2
https://doi.org/10.1006/jmbi.1999.3451
https://doi.org/10.1006/jmbi.1999.3451
Autor:
Ying Li, Abigail Wolfe, Peter J. Felock, Daria J. Hazuda, Youwei Yan, V V Sardana, Joan Zugay-Murphy, Marc V. Witmer, Zhongguo Chen, Mohinder K. Sardana, Bei Xu, James L. Cole, Lawrence C. Kuo
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 55:1906-1910
The C-terminal two-thirds segment of integrase derived from the simian immunodeficiency virus has been cloned, expressed in Escherichia coli, and purified to greater than 95% homogeneity. The protein encompasses amino-acid residues 50–293 and conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b35be474ffa03a53718c11f2ec042ca
https://doi.org/10.1107/s0907444999009610
https://doi.org/10.1107/s0907444999009610
Autor:
Noel Byrne, Sanjeev Munshi, Sujata Sharma, Kaoru Funabashi, Sangita B. Patel, Mari Ikuta, Tomoko Sunami, Yoshikazu Iwasawa, Ronald E. Diehl, Joan Zugay-Murphy, Kevin J. Lumb, Jennifer M. Shipman, Robert F. Smith, Ikuko Takahashi, Dawn L. Hall
Publikováno v:
The Journal of biological chemistry. 285(7)
p70 ribosomal S6 kinase (p70S6K) is a downstream effector of the mTOR signaling pathway involved in cell proliferation, cell growth, cell-cycle progression, and glucose homeostasis. Multiple phosphorylation events within the catalytic, autoinhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad9662dff264b9ac1ee8e95fb821017
https://pubmed.ncbi.nlm.nih.gov/19864428
https://pubmed.ncbi.nlm.nih.gov/19864428