tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β

Autor: Gang Wang, Joan Zhou, Josef Anrather, Kenzo Koizumi, Costantino Iadecola, Steven M. Paul, Ping Zhou, Lingzhi Zhao, Laibaik Park, Sung Ji Ahn, James Seo, Antoine Anfray

Publikováno v: J Neurosci

The amyloid-β (Aβ) peptide, a key pathogenic factor in Alzheimer's disease, attenuates the increase in cerebral blood flow (CBF) evoked by neural activity (functional hyperemia), a vital homeostatic response in which NMDA receptors (NMDARs) play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0ad1ff8a16ed76945ad123c398f167
https://europepmc.org/articles/PMC7574658/

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models

Autor: Vincent Doyeux, Joan Zhou, Gabriel Otte, Victorine Muse, Maxime Berg, Marta Cortes-Canteli, Elizabeth M. Davenport, Oliver Bracko, Myriam Peyrounette, Laibaik Park, Costantino Iadecola, Mohammad Haft-Javaherian, Nozomi Nishimura, Jean C. Cruz Hernandez, Calvin J. Kersbergen, Chris B. Schaffer, Lindsay K. Vinarcsik, Sylvie Lorthois, Yiming Kang, Charles P. Lin, Yohan Davit, Daniel A. Rivera, Jeffrey D. Beverly, Amy F. Smith, Sidney Strickland, Iryna Ivasyk

Publikováno v: Nature neuroscience
Nature neuroscience, vol 22, iss 3
Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2019, 22 (3), pp.413-420. ⟨10.1038/s41593-018-0329-4⟩

International audience; Cerebral blood flow (CBF) reductions in Alzheimer’s disease patients and related mouse models have been recognized for decades, but the underlying mechanisms and resulting consequences for Alzheimer’s disease pathogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a84e94333ebba91f7ccba9f445603c
https://pubmed.ncbi.nlm.nih.gov/30742116

Two-Photon Imaging Reveals Capillary Occlusions are Responsible for Reduced Brain Blood Flow and Cognitive Decline in Alzheimer’s Disease Mouse Models

Autor: Costantino Iadecola, Jeffrey D. Beverly, Nozomi Nishimura, Joan Zhou, Oliver Bracko, Mohammad Haft-Javaherian, Calvin J. Kersbergen, Gabriel Otte, Thom P. Santisakultarm, Laibaik Park, Chris B. Schaffer, Jean C. Cruz Hernandez, Victorine Muse, Yiming Kang, Elizabeth Slack, Iryna Ivasyk, Lindsay K. Vinarcsik

Publikováno v: Optics in the Life Sciences Congress.

Using in vivo nonlinear microscopy, we found 2% of brain capillaries were occluded by an adhered leukocyte in Alzheimer’s disease mice. Blocking this adhesion eliminated these stalls, improved brain blood flow by 30%, and restored spatial memory.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df7e5a18e03e1553e4c2adf0bf428801
https://doi.org/10.1364/brain.2017.brw3b.3

Cortical Microhemorrhages Cause Local Inflammation but Do Not Trigger Widespread Dendrite Degeneration.

Autor: Rosidi, Nathanael L.¹, Joan Zhou¹, Pattanaik, Sanket¹, Peng Wang², Weiyang Jin¹, Brophy, Morgan¹, Olbricht, William L.^1,2, Nishimura, Nozomi¹, Schaffer, Chris B.¹ cs385@cornell.edu

Publikováno v: PLoS ONE. 2011, Vol. 6 Issue 10, p1-16. 16p.

P4‐097: Stalled Blood flow in Brain Capillaries is Responsible for Reduced Cortical Perfusion in a Mouse Model of Alzheimer’s Disease

Autor: Oliver Bracko, Gabriel Otte, Joan Zhou, Victorine Muse, Mohammad Haft-Javaherian, Calvin J. Kersbergen, Thom P. Santisakultarm, Chris B. Schaffer, Jean C. Cruz Hernandez, Nozomi Nishimura, Iryna Ivasyk, Elizabeth Slack, Costantino Iadecola, Yiming Kang, Jeffrey D. Beverly

Publikováno v: Alzheimer's & Dementia. 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26f95f3f768bb0c35a3a643d76abc477
https://doi.org/10.1016/j.jalz.2016.06.2186