Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joan W. Witkin"'
Publikováno v:
Traffic. 3:496-511
In neuroendocrine cells, Ca2+ triggers fusion of granules with the plasma membrane and functions at earlier steps by increasing the size of the readily releasable pool of vesicles. The effect of Ca2+ at early steps of secretion may be due to the recr
Autor:
Joan W. Witkin
Publikováno v:
Microscopy Research and Technique. 44:11-18
The anatomical substrate for coordinated release from the dispersed gonadotropin-releasing hormone (GnRH) neuronal population remains obscure. There is physiological evidence that the GnRH hormone itself has a role in tonic inhibition or modulation o
Publikováno v:
Endocrinology. 140:422-433
We present a quantitative immunocytochemical study of GnRH migration by developmental stage. GnRH peptide was detected in cells of the olfactory epithelium at stage 19. Migration was initiated a few hours later at stage 20. Of interest is the observa
Publikováno v:
Journal of Neuroendocrinology. 9:881-885
A previous study in our laboratory revealed that the cell bodies of gonadotropin releasing hormone (GnRH) neurons in the preoptic area (POA) of early to midpubertal female rhesus monkeys were extensively invested with thick glial processes. Because t
Autor:
Philipp E. Scherer, Vytas A. Bankaitis, Guangyi Wang, Gianming Hao, Giulia Baldini, Joan W. Witkin
Publikováno v:
Journal of Cell Science. 110:505-513
SNAP-25 is a synaptosomal associated protein localized at the plasma membrane of nerve terminals. SNAP-25 associates with syntaxin 1 and vesicle-associated membrane protein-2 (VAMP-2) and is thought to form a complex essential for neurotransmitter re
Autor:
Joan W. Witkin
Publikováno v:
Journal of Neuroendocrinology. 8:601-604
Gonadotropin releasing hormone (GnRH) neurons are typically simple, fusiform cells; however, over the course of prepubertal development increasing numbers take on a 'spiny' appearance. Following gonadectomy there is a decrease in the frequency of the
Autor:
Joan W. Witkin
Publikováno v:
Neuroprotocols. 4:235-239
Changes in the synaptic input to aging neurons can best be evaluated using electron microscopy (EM). Immunocytochemistry is used to identify neuronal populations and to distinguish the chemical identity of their synaptic input, using a double-label p
Autor:
Ann-Judith Silverman, Joan W. Witkin
Publikováno v:
Neuroendocrinology. 59:545-551
In an attempt to understand the regulatory events that control the synthesis of gonadotropin-releasing hormone (GnRH) during the estrous cycle of the rat, we undertook a cellular analysis of time of translation of GnRH mRNA into protein. A specific a
Autor:
M. Dueñas, Byungju Lee, Sang Soo Kang, Richard P. Michael, Kyungjin Kim, Michael H. Hastings, Akane Sano, Luis M. Garcia-Segura, Wan Kyoo Cho, C.K. Murthy, Joan W. Witkin, Prasada Rao, Francis J. P. Ebling, Tami C. Steveson, Jean Rivier, Heidi Wasinger, Elina Linetsky, Andrew N. Clancy, Ignacio Torres-Aleman, Teresa L. Krukoff, Rémi Quirion, W Rowe, Jenn-Tser Pan, Julie A. Chowen, Jack H. Jhamandas, Sonia Luquin, Richard J. Turner, Wolfgang Wuttke, Danielle Gully, Anne Bérod, Richard E. Peter, Jiann-Yueh Yang, Wan Sung Choi, Fukuko Kimura, Arnaud Nicot, William Rostène, Anderson O. L. Wong, Ana Lancha, Robert M. Dores, Elizabeth S. Maywood, Frederick Naftolin, Sang Dai Park, Alena Sumová, Joe Herbert, Byung Nam Cho, Chung Choo Lee, Ann-Judith Silverman, Kim H. Harris, Masugi Nishihara, E. Ron de Kloet, David Vaudry
Publikováno v:
Neuroendocrinology. 59:I-VI
Autor:
Joan W. Witkin
Publikováno v:
Neurobiology of Aging. 13:681-686
Using double-label ultrastructural immunocytochemistry, we found the synaptic input to gonadotropin-releasing hormone (GnRH) neurons in the preoptic area of aged (20 months old), virgin, male Sprague-Dawley rats to be denser than that in young adults