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of 21
pro vyhledávání: '"Joan W. Flacke"'
Autor:
Joan W. Flacke
Publikováno v:
Journal of Cardiothoracic and Vascular Anesthesia. 6:344-359
At this time, the unique attributes of alpha 2-agonists in anesthesia lie in their ability to blunt the adrenergic response to the stresses of major surgery, in patients in whom this response is especially undesirable, without incurring the penalty o
Publikováno v:
Journal of Cardiothoracic and Vascular Anesthesia. 5:175-180
Publikováno v:
Journal of Cardiovascular Pharmacology. 16:616-623
The hemodynamic effects of the alpha 2-adrenergic agonist, dexmedetomidine (DM), were studied in eight anesthetized, autonomically denervated dogs. Autonomic block decreased mean arterial pressure (MAP) and cardiac index (CI) by approximately 20% to
Publikováno v:
Canadian Journal of Anaesthesia. 37:238-244
Reversal of opioid effects by naloxone (NX) can lead to significant cardiovascular problems. We have reported previously that hypercapnic dogs develop greater increases in blood pressure and plasma catecholamine (CA) levels than hypocapnic ones when
Publikováno v:
Journal of cardiothoracic and vascular anesthesia. 7(1)
In addition to central effects, which are the basis of their use in anesthesiology, α 2 -adrenergic agonists have direct peripheral cardiovascular effects. Dexmedetomidine (DM) has been found to depress cardiac function in dogs, even after autonomic
Publikováno v:
Journal of cardiothoracic and vascular anesthesia. 6(4)
Dexmedetomidine (DM) was studied in the isolated dog heart in the form of a Starling heart-lung preparation, (HLP). Hearts were subjected to increased loading by (a) increasing cardiac output, and (b) increasing systemic resistance. Results are depic
Publikováno v:
Anesthesiology. 67:11-19
The authors examined the effect of clonidine, a preferential alpha 2-adrenergic agonist, upon narcotic requirements, hemodynamics, and adrenergic responses during the perioperative period in patients undergoing CABG surgery. Anesthesia was provided b
Effects of Fentanyl, Naloxone, and Clonidine on Hemodynamics and Plasma Catecholamine Levels in Dogs
Publikováno v:
Anesthesia & Analgesia. 62:305
A 50-micrograms/kg dose of fentanyl, given intravenously in divided doses to dogs under enflurane-nitrous oxide anesthesia caused sharp decreases in heart rate (HR), arterial blood pressure (AP), left ventricular dP/dt, and plasma levels of catechola
Autor:
D. Wong, W. E. Flacke, B J Kripke, Joan W. Flacke, B. C. Bloor, A P Van Etten, C M Warneck, R L Katz
Publikováno v:
Survey of Anesthesiology. 30:131
A double-blind study comparing four narcotic analgesics of different potencies, meperidine, morphine, fentanyl, and sufentanil, was performed on consenting patients undergoing general or orthopedic surgery under balanced anesthesia. Blood pressure, m
Autor:
Christopher A. Mills, B. C. Bloor, Jordan D. Miller, Werner Flacke, Loyal Davis, Joan W. Flacke
Publikováno v:
Anesthesia & Analgesia. 67:730
Clinical reports, as well as animal studies, have described cardiovascular and sympathetic stimulation after the administration of naloxone (NX) to reverse opioid-induced respiratory depression. This investigation examines the effect of Paco2 on hemo