Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Joan W Conaway"'
Autor:
Xiaoming Zhao, Jiaming Su, Fei Wang, Da Liu, Jian Ding, Yang Yang, Joan W Conaway, Ronald C Conaway, Lingling Cao, Donglu Wu, Min Wu, Yong Cai, Jingji Jin
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003940 (2013)
hMOF (MYST1), a histone acetyltransferase (HAT), forms at least two distinct multiprotein complexes in human cells. The male specific lethal (MSL) HAT complex plays a key role in dosage compensation in Drosophila and is responsible for histone H4K16a
Externí odkaz:
https://doaj.org/article/c22fd252dfda40c09f4c06f5e0da7e83
Autor:
Adalberto Costessi, Nawel Mahrour, Vikram Sharma, Rieka Stunnenberg, Marieke A Stoel, Esther Tijchon, Joan W Conaway, Ronald C Conaway, Hendrik G Stunnenberg
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42822 (2012)
The human tumour antigen PRAME (preferentially expressed antigen in melanoma) is frequently overexpressed during oncogenesis, and high PRAME levels are associated with poor clinical outcome in a variety of cancers. However, the molecular pathways in
Externí odkaz:
https://doaj.org/article/83a38e0689f5471b9000667dd21d99a6
Autor:
Hidefumi Suzuki, Ryota Abe, Miho Shimada, Tomonori Hirose, Hiroko Hirose, Keisuke Noguchi, Yoko Ike, Nanami Yasui, Kazuki Furugori, Yuki Yamaguchi, Atsushi Toyoda, Yutaka Suzuki, Tatsuro Yamamoto, Noriko Saitoh, Shigeo Sato, Chieri Tomomori-Sato, Ronald C. Conaway, Joan W. Conaway, Hidehisa Takahashi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Transcription termination is generally accompanied by the 3′-end processing of transcripts. Here the authors demonstrate a role for Mediator in transcript end site proximal pausing of replication-dependent histone genes.
Externí odkaz:
https://doaj.org/article/d064a681bc454dca9b24cf1a9cc949a4
Autor:
Takashi Yasukawa, Aya Tsutsui, Chieri Tomomori-Sato, Shigeo Sato, Anita Saraf, Michael P. Washburn, Laurence Florens, Tohru Terada, Kentaro Shimizu, Ronald C. Conaway, Joan W. Conaway, Teijiro Aso
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3478-3491.e6 (2020)
Summary: Alzheimer’s disease (AD) is a progressive neurodegenerative disease caused by accumulations of Aβ peptides. Production and fibrillation of Aβ are downregulated by BRI2 and BRI3, which are physiological inhibitors of amyloid precursor pro
Externí odkaz:
https://doaj.org/article/25b40895c06f4376bab27bd94b941627
Autor:
Jaya Krishnan, Chris W. Seidel, Ning Zhang, Narendra Pratap Singh, Jake VanCampen, Robert Peuß, Shaolei Xiong, Alexander Kenzior, Hua Li, Joan W. Conaway, Nicolas Rohner
Publikováno v:
Nature Genetics. 54:684-693
Cis-regulatory changes are key drivers of adaptative evolution. However, their contribution to the metabolic adaptation of organisms is not well understood. Here, we used a unique vertebrate model, Astyanax mexicanus-different morphotypes of which su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251d37d2acc0e1d7e1caebdac1d91283
https://doi.org/10.1038/s41588-022-01049-4
https://doi.org/10.1038/s41588-022-01049-4
Autor:
Mark E. Parrish, Robb Krumlauf, Bony De Kumar, Laurence Florens, Joan W. Conaway, Ariel Paulson, Narendra Pratap Singh, Ying Zhang, Kausik Si
Publikováno v:
Genes Dev
Gene duplication and divergence is a major driver in the emergence of evolutionary novelties. How variations in amino acid sequences lead to loss of ancestral activity and functional diversification of proteins is poorly understood. We used cross-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce9a1cd711cb5623d5d0f3c2caa373d
https://doi.org/10.1101/gad.342329.120
https://doi.org/10.1101/gad.342329.120
Autor:
Takashi Yasukawa, Shachi Bhatt, Tamotsu Takeuchi, Junya Kawauchi, Hidehisa Takahashi, Aya Tsutsui, Takuya Muraoka, Makoto Inoue, Masayuki Tsuda, Shigetaka Kitajima, Ronald C. Conaway, Joan W. Conaway, Paul A. Trainor, Teijiro Aso
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1129-1136 (2012)
Elongin A increases the rate of RNA polymerase II (pol II) transcript elongation by suppressing transient pausing by the enzyme. Elongin A also acts as a component of a cullin-RING ligase that can target stalled pol II for ubiquitylation and proteaso
Externí odkaz:
https://doaj.org/article/2a853751c7664e919d8d78e9e8cef278
Autor:
Chieri Tomomori-Sato, Soon-Keat Ooi, Zhihui Wen, Ying Zhang, Joan W. Conaway, Jay R. Unruh, Michael P. Washburn, Ronald C. Conaway, Laurence Florens, Charles A.S. Banks, Shigeo Sato
Publikováno v:
Proc Natl Acad Sci U S A
The SNF2 family ATPase Amplified in Liver Cancer 1 (ALC1) is the only chromatin remodeling enzyme with a poly(ADP-ribose) (PAR) binding macrodomain. ALC1 functions together with poly(ADP-ribose) polymerase PARP1 to remodel nucleosomes. Activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d746199c3a60d7a1689753731b73d067
https://europepmc.org/articles/PMC8433585/
https://europepmc.org/articles/PMC8433585/
Autor:
Ronald C. Conaway, Joan W. Conaway
Publikováno v:
Nature Structural & Molecular Biology. 26:771-776
The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious biochemical investigations of eukaryotic transcription and the identification of eukaryotic transcription factors. Here we describe this adventure from our vantag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10efb412cf969087ea9da93b0319b1cf
https://doi.org/10.1038/s41594-019-0283-1
https://doi.org/10.1038/s41594-019-0283-1
Autor:
Marco Blanchette, Benjamin A. Story, Wanqing Shao, Ronald C. Conaway, Theophilus T. Tettey, Julia Zeitlinger, Robert L. Glaser, Hua Li, Joan W. Conaway, Zach H. Goode, Xin Gao, Alex D. Chitsazan, Christopher Seidel
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3770-3779.e7 (2019)
Summary: FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro. In this repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f380c44f44ce8be53497cc342c0d0c
http://www.sciencedirect.com/science/article/pii/S2211124719307387
http://www.sciencedirect.com/science/article/pii/S2211124719307387