Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joan Urmson"'
Autor:
Lin Fu Zhu, Annette Sedlmeyer, Marjan Afrouzian, Joan Urmson, Philip F. Halloran, Luis G. Hidalgo, Wolfram J. Jabs, Vido Ramassar
Publikováno v:
American Journal of Transplantation. 3:1501-1509
The natural history and pathogenesis of the pathologic lesions that define rejection of kidney transplants have not been well characterized. We studied the evolution of the pathology of rejection in mouse kidney allografts, using four strain combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c32413776d44f9dd7721c50d9a4e275
https://doi.org/10.1046/j.1600-6135.2003.00269.x
https://doi.org/10.1046/j.1600-6135.2003.00269.x
Publikováno v:
Journal of the American Society of Nephrology. 13:1199-1209
In many circumstances kidney transplants remain viable despite extensive inflammation, permitting rejection episodes to be reversed. The mechanisms by which the kidney resists host effector mechanisms are not known. In mouse kidney transplants, resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2307ef7476a5ae063720d9b061dbf8
https://doi.org/10.1097/01.asn.0000013302.11876.a5
https://doi.org/10.1097/01.asn.0000013302.11876.a5
Publikováno v:
American Journal of Transplantation. 1:211-221
Class II transactivator (CIITA) induces transcription of MHC class II genes, and induces class I in some cell lines. We examined the effect of CIITA deficiency on class I and II expression in mouse kidney. In CIITA knockout (CIITAKO) mice, basal clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3723012751c8ca5b8bc355a31758c8
https://doi.org/10.1034/j.1600-6143.2001.001003211.x
https://doi.org/10.1034/j.1600-6143.2001.001003211.x
Publikováno v:
Transplant Immunology. 6:23-32
The immunosuppressive drug mycophenolate mofetil (MMF) acts by releasing mycophenolic acid (MPA), which inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH) and thus inhibits de novo purine synthesis. Unlike cyclosporine (CsA), MMF has no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940b6f35830eb040c80d6383bf13bd0
https://doi.org/10.1016/s0966-3274(98)80031-2
https://doi.org/10.1016/s0966-3274(98)80031-2
Publikováno v:
Transplantation. 64:1657-1664
Background Tissue injury induces MHC class II expression, which could be important in the recognition of that tissue as an allograft. The class II transcriptional activator (CIITA) is the major regulator of basal and induced MHC class II expression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c3f429b0222f2f3b5798f34276522a3
https://doi.org/10.1097/00007890-199712270-00005
https://doi.org/10.1097/00007890-199712270-00005
Publikováno v:
Transplantation. 62:1889-1894
We examined the expression of MHC class I and II in the arterial endothelium of interferon-γ (IFN-γ, GKO) and IFN-γ-R (IFN-γ-R, GRKO) gene knockout mice in comparison with mice with intact IFN-γ and IFN-γ-R genes, BALB/c and 129Sv/J wild-type,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95410e57c001e104186d549c20d88a6
https://doi.org/10.1097/00007890-199612270-00036
https://doi.org/10.1097/00007890-199612270-00036
Publikováno v:
Transplantation. 61:1618-1624
Cyclosporine (CsA) blocks T cell responses in vitro by inhibiting the phosphatase activity of calcineurin (CN) and thus preventing the activation of cytokine transcription. In the study presented here, we measured the extent of inhibition of these fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b2042f28e111529bc84f04223b6c08
https://doi.org/10.1097/00007890-199606150-00012
https://doi.org/10.1097/00007890-199606150-00012
Publikováno v:
Journal of the American Society of Nephrology. 7:710-720
Renal ischemic injury evokes an inflammatory response with increased cytokine and major histocompatibility complex (MHC) expression and a mild interstitial infiltrate. This "injury response" could contribute to the tendency of ischemically injured re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c093417381d4a3fda3a4d3d6bd820d
https://doi.org/10.1681/asn.v75710
https://doi.org/10.1681/asn.v75710
Publikováno v:
Transplantation. 60:1560-1564
We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-γ (IFN-γ) using IFN-γ gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff7bf184ad1e13a02b149a276c8c0068
https://doi.org/10.1097/00007890-199560120-00031
https://doi.org/10.1097/00007890-199560120-00031
Publikováno v:
Transplantation. 59:565-572
We noted previously that ischemic acute tubular necrosis (ATN) induces local expression of MHC products in renal epithelium. The present investigations were conducted to establish the role of IFN-gamma in the regulation of MHC antigen expression in A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97f0d6499026b46efcc48df5c70f1fb
https://doi.org/10.1097/00007890-199502270-00022
https://doi.org/10.1097/00007890-199502270-00022