Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Joan S. Steffan"'
Autor:
Gianna M. Fote, Joan S. Steffan
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 29-33 (2022)
Human APOE4 (apolipoprotein E4 isoform) is a powerful genetic risk factor for late-onset Alzheimer disease (AD). Many groups have investigated the effect of APOE4 on the degradation of amyloid β (Aβ), the main component of plaques found in the brai
Externí odkaz:
https://doaj.org/article/6dfde4e7733d4991b741280568a10632
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d74b2e4cb1a84ae98fd95f8389c0a7c0
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions
Externí odkaz:
https://doaj.org/article/2fc5155c4b834bdf97f0aa5db0218942
Publikováno v:
Matrix Biology Plus, Vol 12, Iss , Pp 100089- (2021)
Cellular adhesive connections directed by the extracellular matrix (ECM) and maintenance of cellular homeostasis by autophagy are seemingly disparate functions that are molecularly intertwined, each regulating the other. This is an emerging field in
Externí odkaz:
https://doaj.org/article/afd54e2517e9412daf298e30dcc82d7b
Autor:
Jack C. Reidling, Aroa Relaño-Ginés, Sandra M. Holley, Joseph Ochaba, Cindy Moore, Brian Fury, Alice Lau, Andrew H. Tran, Sylvia Yeung, Delaram Salamati, Chunni Zhu, Asa Hatami, Carlos Cepeda, Joshua A. Barry, Talia Kamdjou, Alvin King, Dane Coleal-Bergum, Nicholas R. Franich, Frank M. LaFerla, Joan S. Steffan, Mathew Blurton-Jones, Charles K. Meshul, Gerhard Bauer, Michael S. Levine, Marie-Francoise Chesselet, Leslie M. Thompson
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 58-72 (2018)
Summary: Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment
Externí odkaz:
https://doaj.org/article/6a20e0b98a194e96bbd0862727f88f6d
Autor:
Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P. Bates, Daniel Aeschlimann, Joan S. Steffan, Stephan von Hörsten
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8914 (2021)
Mammalian transglutaminases (TGs) catalyze calcium-dependent irreversible posttranslational modifications of proteins and their enzymatic activities contribute to the pathogenesis of several human neurodegenerative diseases. Although different transg
Externí odkaz:
https://doaj.org/article/9749844d2fac433ebde9e11e9bb1738a
Autor:
Jacqueline Gire O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee, Malini Vashishtha, Barbara L. Apostol, Thomas Peter Nicholson, Katalin Illes, Ya-Zhen Zhu, Mary Dasso, Gillian P. Bates, Marian Difiglia, Beverly Davidson, Erich E. Wanker, J. Lawrence Marsh, Christopher D. Lima, Joan S. Steffan, Leslie M. Thompson
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 362-375 (2013)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, sh
Externí odkaz:
https://doaj.org/article/2cae4460f6614c9f87bd7c29ab921075
Autor:
Nicole M. Wakida, Alice L. Lau, Jessica Nguyen, Gladys Mae S. Cruz, Gianna M. Fote, Joan S. Steffan, Leslie M. Thompson, Michael W. Berns
Publikováno v:
Journal of Huntington's disease. 11(1)
Background: In recent years the functions of astrocytes have shifted from conventional supportive roles to also include active roles in altering synapses and engulfment of cellular debris. Recent studies have implicated astrocytes in both protective
Autor:
Joan S. Steffan, Anja Schulze-Krebs, Judith Stemick, Julia Harrer, Stephan von Hörsten, Daniel Aeschlimann, Gillian P. Bates, Fabio Canneva, Anne-Christine Plank
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International journal of molecular sciences, vol 22, iss 16
International Journal of Molecular Sciences, Vol 22, Iss 8914, p 8914 (2021)
Volume 22
Issue 16
International journal of molecular sciences, vol 22, iss 16
International Journal of Molecular Sciences, Vol 22, Iss 8914, p 8914 (2021)
Mammalian transglutaminases (TGs) catalyze calcium-dependent irreversible posttranslational modifications of proteins and their enzymatic activities contribute to the pathogenesis of several human neurodegenerative diseases. Although different transg
Autor:
Soe Soe Thein, Edwin S. Monuki, Michael J. Neel, Ryan G. Lim, Joan S. Steffan, Alice L. Lau, Jack C. Reidling, Sarah Hernandez, Sylvia Y. Yeung, Leslie M. Thompson, David E. Housman, Gianna M. Fote, Joseph Ochaba, Marketta Kachemov, Malcolm Casale
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by expansion of a polyglutamine repeat within the huntingtin (HTT) protein. A normal function of HTT is that of a scaffold for selective autophagy, a mechanis