Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Joan S, Jorgensen"'
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
STARD1 moves cholesterol (CHOL) from the outer mitochondrial membrane (OMM) to the inner membrane (IMM) in steroidogenic cells. This activity is integrated into CHOL trafficking and synthesis homeostasis, involving uptake through SR-B1 and LDL recept
Externí odkaz:
https://doaj.org/article/1b0fbd0ce5154441be231a36c030983f
Autor:
Anbarasi Kothandapani, Samantha R Lewis, Jessica L Noel, Abbey Zacharski, Kyle Krellwitz, Anna Baines, Stephanie Winske, Chad M Vezina, Elena M Kaftanovskaya, Alexander I Agoulnik, Emily M Merton, Martin J Cohn, Joan S Jorgensen
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008810 (2020)
Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3XtJ mutant mice
Externí odkaz:
https://doaj.org/article/c4d27519870641df92699837de73e702
Autor:
Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-Chung Hui, Dagmar Wilhelm, Joan S Jorgensen
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007488 (2018)
Women and other mammalian females are born with a finite supply of oocytes that determine their reproductive lifespan. During fetal development, individual oocytes are enclosed by a protective layer of granulosa cells to form primordial follicles tha
Externí odkaz:
https://doaj.org/article/10d4f1998aaa4d66826613474a5d568e
Spontaneous abortions have been reported to affect up to 43% of parous women, with over 20% occurring before pregnancy is clinically diagnosed. Establishment of pregnancy is critically dependent on proper embryo-uterine interactions at the time of im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d435945d08b879a872a21026c48940
https://doi.org/10.1101/2021.05.06.442331
https://doi.org/10.1101/2021.05.06.442331
Publikováno v:
Endocrinology
Two specialized functions of cholesterol during fetal development include serving as a precursor to androgen synthesis and supporting hedgehog (HH) signaling activity. Androgens are produced by the testes to facilitate masculinization of the fetus. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084b438781a1db5f94615a8b687e5144
https://pubmed.ncbi.nlm.nih.gov/33784378
https://pubmed.ncbi.nlm.nih.gov/33784378
Autor:
Ryan M. Brown, Megan L. Koth, Linda Wang, Sarah A. Shaw, Anqi Fu, Kathleen J. Krentz, Chi-chung Hui, Joan S. Jorgensen, Xiaoyun Zhang
Publikováno v:
Biol Reprod
Healthy development of ovarian follicles depends on appropriate interactions and function between oocytes and their surrounding granulosa cells. Previously, we showed that double knockout of Irx3 and Irx5 (Irx3/5 DKO) in mice resulted in abnormal fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2993597ca10767c610a66d93aee89e
https://europepmc.org/articles/PMC7822710/
https://europepmc.org/articles/PMC7822710/
GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation
Autor:
Samantha R. Lewis, Elena M. Kaftanovskaya, Stephanie Winske, Chad M. Vezina, Martin J. Cohn, Anbarasi Kothandapani, Anna Baines, Jessica Noel, Abbey Zacharski, Emily M. Merton, Alexander I. Agoulnik, Joan S. Jorgensen, Kyle Krellwitz
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008810 (2020)
PLoS Genetics
PLoS Genetics
Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3XtJ mutant mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c6ec7e591c94f6f2b3476855c12d91
https://doaj.org/article/c4d27519870641df92699837de73e702
https://doaj.org/article/c4d27519870641df92699837de73e702
Autor:
Joan S. Jorgensen, Megan L. Koth, Christopher R. Futtner, Anbarasi Kothandapani, Humphrey H.-C. Yao, Annie Novak, S. Alexandra Garcia-Moreno, Barbara Nicol, Kirsten A. Holthusen, Keer Jiang, Makoto Mark Taketo, Danielle M. Maatouk
Publikováno v:
Development.
Members of the Iroquois B (IrxB) homeodomain cluster genes, specifically Irx3 and Irx5, are critical for heart, limb, and bone development. Recently, we reported their importance for oocyte and follicle survival within the developing ovary. Irx3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30c8e20d08763594fe42d9c46721a3a
https://doi.org/10.1242/dev.183814
https://doi.org/10.1242/dev.183814
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 20:100284
The hypothalamic-pituitary-gonadal (HPG) axis feedback loop is critical in the regulation of the endocrine system. Dysregulation or dysfunction of the HPG axis can impact reproductive, psychiatric, and metabolic health. The gut microbiota is suggeste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4000af80579d3aeba4dabcf3b3507b6
https://doi.org/10.1016/j.coemr.2021.100284
https://doi.org/10.1016/j.coemr.2021.100284
Autor:
Michele Campaigne Larsen, Anbarasi Kothandapani, Colin R. Jefcoate, Joan S. Jorgensen, Jinwoo Lee
Publikováno v:
Molecular and Cellular Endocrinology. 531:111265
STARD1 stimulates cholesterol transfer to mitochondrial CYP11A1 for conversion to pregnenolone. A cholesterol-binding START domain is guided by an N-terminal domain in a cell selective manner. Fetal and adult Leydig cells (FLC, ALC) show distinct Sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed10e38adcb200f018876066437bb7c5
https://doi.org/10.1016/j.mce.2021.111265
https://doi.org/10.1016/j.mce.2021.111265