Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

Autor: Lorena González, Lucía Díaz, Joan Pous, Blazej Baginski, Anna Duran-Corbera, Margherita Scarpa, Isabelle Brun-Heath, Ana Igea, Pau Martin-Malpartida, Lidia Ruiz, Chiara Pallara, Mauricio Esguerra, Francesco Colizzi, Cristina Mayor-Ruiz, Ricardo M. Biondi, Robert Soliva, Maria J. Macias, Modesto Orozco, Angel R. Nebreda

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disord

Externí odkaz: https://doaj.org/article/875e0b5f72914dd0a22c1161dc475f7f

Crystal structure of a complex of DNA with one AT-hook of HMGA1.

Autor: Elsa Fonfría-Subirós, Francisco Acosta-Reyes, Núria Saperas, Joan Pous, Juan A Subirana, J Lourdes Campos

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37120 (2012)

We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)(2), which has two potential AATT interacting

Externí odkaz: https://doaj.org/article/fa0cc79827a74295aba4fd1fe3c4ad07

Humidity control can compensate for the damage induced in protein crystals by alien solutions

Autor: Joan Pous, S. Rodriguez-Puente, R. Oliete, Alicia Guasch, Michael E. Johnson, L. Martinelli, Cele Abad-Zapatero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

et al.
The use of relative humidity control of protein crystals to overcome some of the shortcomings of soaking ligands (i.e. inhibitors, substrate analogs, weak ligands) into pre-grown apoprotein crystals has been explored. Crystals of PurE (EC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d5708ab67bdefff6e891b4e0b27200
https://doi.org/10.1107/s174430911103377x

The interaction of manganese ions with DNA

Autor: Juan A. Subirana, Hans Millonig, Joan Pous, Catherine Gouyette, J. Lourdes Campos

Publikováno v: Journal of Inorganic Biochemistry. 103:876-880

We present the structure of the duplex formed by a fragment of auto-complementary DNA with the sequence d(CGTTAATTAACG). The structure was determined by X-ray crystallography. Up to date it is the first structure presenting the interaction between a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2727f91b207c0bacec9aed22f68f25e3
https://doi.org/10.1016/j.jinorgbio.2009.03.004

Structure of the N-terminal domain of the protein Expansion: An 'Expansion' to the Smad MH2 fold

Autor: Mads Beich-Frandsen, Jordi Benach, Maria J. Macias, Antoni Riera, Joan Pous, Eric Aragón, Marta Llimargas

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Acta Crystallographica Section D: Biological Crystallography
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC

Supporting information at doi:10.1107/S1399004715001443/kw5112sup1.pdf
Gene-expression changes observed in Drosophila embryos after inducing the transcription factor Tramtrack led to the identification of the protein Expansion. Expansion contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93c881e5c65acb9dfdedca21bea4c0c
http://hdl.handle.net/10261/124106