Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joan Nieto"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9640 (2020)
Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyl
Externí odkaz:
https://doaj.org/article/9ae0f8b6b899454ab1a7d6ed3c85adb5
Autor:
Teresa Mairal, Joan Nieto, Marta Pinto, Maria Rosário Almeida, Luis Gales, Alfredo Ballesteros, José Barluenga, Juan J Pérez, Jesús T Vázquez, Nuria B Centeno, Maria Joao Saraiva, Ana M Damas, Antoni Planas, Gemma Arsequell, Gregorio Valencia
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4124 (2009)
The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding s
Externí odkaz:
https://doaj.org/article/69a1e8debb4b437a809014b9a0c39525
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9640, p 9640 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9640, p 9640 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyl
Publikováno v:
Journal of Biological Chemistry. 281:1432-1441
The structure and dynamics of the enzyme-substrate complex of Bacillus 1,3–1,4-β-glucanase, one of the most active glycoside hydrolases, is investigated by means of Car-Parrinello molecular dynamics simulations (CPMD) combined with force field mol
Autor:
Alfredo Ballesteros, Gregorio Valencia, Maria Rosário Almeida, Maria Vilaró, Gemma Arsequell, Juan Ramón La Parra, Joan Nieto, Antoni Planas
Publikováno v:
ACS combinatorial science. 17(1)
Two series of iododiflunisal and diflunisal analogues have been obtained by using a two step sequential reaction solution-phase parallel synthesis. The synthesis combined an aqueous Suzuki-Miyaura cross-coupling and a mild electrophilic aromatic iodi
Autor:
Gemma Arsequell, Antoni Planas, Ignacio Dolado, Maria João Saraiva, Joan Nieto, Gregori Valencia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
7 pages, 4 figures, 1 scheme, 2 tables.-- PMID: 15762752 [PubMed].-- Printed version published Mar 2005.
Stabilization of tetrameric transthyretin (TTR) by binding of small ligands is a current strategy aimed at inhibiting amyloid fibrillogenesi
Stabilization of tetrameric transthyretin (TTR) by binding of small ligands is a current strategy aimed at inhibiting amyloid fibrillogenesi
Publikováno v:
Journal of the American Chemical Society. 134:8436-8438
Binding isotope effects for l-aspartate reacting with the inactive K258A mutant of PLP-dependent aspartate aminotransferase to give a stable external aldimine intermediate are reported. They provide direct evidence for electronic ground-state destabi
Publikováno v:
Journal of Heterocyclic Chemistry. 37:1203-1208
An efficient and versatile synthesis of variously substituted 3-(hydroxymethyl)-4H-chromen-4-ones is reported. The compounds are prepared by hydroxymethylation of the precursor 2-hydroxy-4-chromanones followed by acid dehydration.
The catalytic effects of perdeuterating the pyridoxal phosphate-dependent enzyme alanine racemase from Geobacillus stearothermophilus are reported. The mass of the heavy perdeuterated form is ~5.5% greater than that of the protiated form, causing kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f866125870960c055dd55bdb286f5194
https://europepmc.org/articles/PMC3579662/
https://europepmc.org/articles/PMC3579662/
Autor:
Nuria B. Centeno, Cele Abad-Zapatero, Marta Pinto, Gregori Valencia, Joan Nieto, Antoni Planas, Daniel Blasi, Gemma Arsequell, Jordi Quintana
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
We have previously reported the design and synthesis of ligands that stabilize Transthyretin protein (TTR) in order to obtain therapeutically active compounds for Familial Amyloid Polyneuropathy (FAP). We are hereby reporting a drug design strategy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3130c163c24f628a943dfc1db0cdd4a
http://hdl.handle.net/10261/49581
http://hdl.handle.net/10261/49581