Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joan Miguel Romero"'
Autor:
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura M. Williamson, Barbara Grünwald, Grainne M. O’Kane, Steven J. M. Jones, Marco. A. Marra, Julie M. Wilson, Steven Gallinger, Janessa Laskin, George Zogopoulos
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Improved predictors of T cell-inflammation are needed to identify ICI-responsive tumor
Externí odkaz:
https://doaj.org/article/8dd7df9c6c22430ba3c3588f08acd012
Autor:
Bryn Golesworthy, Yifan Wang, Amanda Tanti, Alain Pacis, Joan Miguel Romero, Adeline Cuggia, Celine Domecq, Guillaume Bourdel, Robert E. Denroche, Gun Ho Jang, Robert C. Grant, Ayelet Borgida, Barbara T. Grünwald, Anna Dodd, Julie M. Wilson, Guillaume Bourque, Grainne M. O’Kane, Sandra E. Fischer, Chelsea Maedler Kron, Pierre-Olivier Fiset, Atilla Omeroglu, William D. Foulkes, Steven Gallinger, Marie-Christine Guiot, Zu-Hua Gao, George Zogopoulos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The immune contexture of pancreatic ductal adenocarcinoma (PDAC) is generally immunosuppressive. A role for immune checkpoint inhibitors (ICIs) in PDAC has only been demonstrated for the rare and hypermutated mismatch repair (MMR) deficient (MMR-d) s
Externí odkaz:
https://doaj.org/article/05e7545055d64a62972ea705edc792bf
Autor:
Joan Miguel Romero, Mark Sorin, Matthew Dankner, Heather Whittaker, April Rose, Jacquetta Trasler, Mark J Eisenberg
Publikováno v:
Clinical and Investigative Medicine. 46:E4-14
Purpose: Women have traditionally been underrepresented in MD and MD-PhD training programs. Here, we describe the changing demographics of an MD-PhD Program over three distinct time intervals. Methods: We designed a 64-question survey and sent it to
Autor:
George Zogopoulos, Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura Williamson, Barbara Grünwald, Grainne O'Kane, Steven Jones, Marco Marra, Julie Wilson, Steven Gallinger, Janessa Laskin
Immune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Novel predictors of T cell-inflammation are needed to identify ICI-responsive tumor subsets in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60eb048a00be8386f08c785c9fd24cef
https://doi.org/10.21203/rs.3.rs-2417294/v1
https://doi.org/10.21203/rs.3.rs-2417294/v1
Autor:
Joan Miguel Romero, Nikita Kalashnikov
Publikováno v:
JAMA Surgery. 157:742
Autor:
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura Williamson, Barbara Grunwald, Grainne M. O'Kane, Julie Wilson, Steven Gallinger, Janessa J. Laskin, George Zogopoulos
Publikováno v:
Journal of Clinical Oncology. 40:2558-2558
2558 Background: Immune checkpoint inhibitors (ICI) are highly effective in select cancers. Novel predictors of T cell-inflammation may identify a broader subset of tumors with ICI responsiveness. Our group has identified four chemokines (CCL4, CCL5,
Autor:
Kazeera Aliar, Steven Gallinger, Geoffroy Andrieux, Jennifer J. Knox, Grainne M. O'Kane, Laura Tamblyn, Peter Bronsert, Nikolina Radulovich, Antoine Devisme, Andrew Macklin, Joan Miguel Romero, Prashant Bavi, Barbara Grünwald, Robert E. Denroche, Curtis W. McCloskey, Faiyaz Notta, Julie M. Wilson, Melanie Boerries, Foram Vyas, Thomas Kislinger, Sandra Fischer, Gun Ho Jang, Rama Khokha
SummaryPancreatic ductal adenocarcinoma (PDAC) remains resistant to most treatments and demonstrates a complex pathobiology. Here, we deconvolute regional heterogeneity in the human PDAC tumor microenvironment (TME), a long-standing obstacle, to defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7159ce9a5c8fdf129338ba062b983cb
https://doi.org/10.1101/2021.02.18.431890
https://doi.org/10.1101/2021.02.18.431890
Autor:
Christopher Sherman, Arun Seth, Yutaka Amemiya, Linda Sugar, Robert K. Nam, Joan Miguel Romero, Christopher J.D. Wallis, Melina Tsagaris, Tania Benatar
Publikováno v:
Oncotarget
MicroRNAs (miRNAs) are small noncoding RNA molecules that post-transcriptionally regulate gene expression. Dysregulation of miRNAs is frequently associated with disease and, in particular, is involved in prostate cancer progression. Next generation m
Autor:
Robert E. Denroche, Kazeera Aliar, Melanie Boerries, Foram Vyas, Curtis W. McCloskey, Steven Gallinger, Thomas Kislinger, Faiyaz Notta, Prashant Bavi, Geoffroy Andrieux, Peter Bronsert, Molly Udaskin, Laura Tamblyn, Antoine Devisme, Sandra Fischer, Julie M. Wilson, Gun Ho Jang, Rama Khokha, Jennifer J. Knox, Grainne M. O'Kane, Nikolina Radulovich, Barbara Grünwald, Joan Miguel Romero, Andrew Macklin
Publikováno v:
Cell. 184:5577-5592.e18
Intratumoral heterogeneity is a critical frontier in understanding how the tumor microenvironment (TME) propels malignant progression. Here, we deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multiOMI
Autor:
Stephanie Totten, Joan Miguel Romero
Publikováno v:
JAMA Oncology. 7:1066