Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

Autor: Steven McKinney, Cristina E. Tognon, Thomas G. P. Grunewald, Nancy E. LePard, Debjit Khan, Franck Tirode, Olivier Delattre, Shamil Hajee, Gabriel Leprivier, Hongwei Cheng, Andrew I. Minchinton, Alastair H. Kyle, Jason N. Berman, Joan Mathers, Momir Bosiljcic, Poul H. Sorensen, Dale Corkery, Yuzhuo Wang, Graham Dellaire, Amal El-Naggar, Jennifer H.E. Baker, Kevin L. Bennewith, Gian Luca Negri, Syam Prakash Somasekharan, Chansey J. Veinotte

Publikováno v: Cancer Cell. 27(5):682-697

SummaryMetastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. Previous research identified a crucial role for YB-1 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9118aef5156df4c6000b433ae16196

Novel Fluorescent Ligase Detection Reaction and Flow Cytometric Analysis of SYT-SSX Fusions in Synovial Sarcoma

Autor: Nancy E. Joste, John X. O'Connell, Robyn L. Gaffney, Joan Mathers, Kelly Garner, David S. Viswanatha, Artemis Chakerian

Publikováno v: The Journal of Molecular Diagnostics. 5:127-135

Synovial sarcomas (SS) are characterized by the t(X;18)(p11;q11) translocation and its resultant fusion gene, SYT-SSX. Two homologues of the SSX gene (ie, SSX1 and SSX2) are involved in the vast majority of SS and the SYT-SSX1 type of fusion has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494538e0b1c63e7ab73cc73c9987ed7e
https://doi.org/10.1016/s1525-1578(10)60462-x

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Autor: Jason D. Galpin, Gabriel Leprivier, Dagmar E. Ehrnhoefer, Syam Prakash Somasekharan, Christopher A. Ahern, Liheng Li, Joan Mathers, Roberto Nitsch, Christopher J. Carnie, Sonia Franciosi, Barak Rotblat, Martina Metzler, Amber L. Southwell, Mads Daugaard, Tiffany Tang, Brian Kwok, Yu Deng, Gerry Melino, Niels H. Skotte, Dieter Fink, Adi Barokas, Naniye Malli Cetinbas, Josef M. Penninger, Michael R. Hayden, Poul H. Sorensen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 111(8)

Oxidative stress plays a key role in late onset diseases including cancer and neurodegenerative diseases such as Huntington disease. Therefore, uncovering regulators of the antioxidant stress responses is important for understanding the course of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d244ec2fbed888ff4da4c734ee60b8c2
https://pubmed.ncbi.nlm.nih.gov/24516159

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

Autor: Brian Kwok, Stephanie Smith, Michael Pollak, Sameer Agnihotri, Gaëlle Bridon, Amal El-Naggar, Michael D. Taylor, Christopher G. Proud, Mary Bowden, Marcel Kool, Marc Remke, Ye Wang, Syam Prakash Somasekharan, Xiaochong Wu, Bin Yu, Poul H. Sorensen, Thomas Hielscher, Andrey Korshunov, Abigail Rachele F. Mateo, Adi Barokas, Martin E. Gleave, Christopher A. Ahern, Jason D. Galpin, Russell G. Jones, Gabriel Leprivier, Joan Mathers, Adrian M. Dubuc, Paul A. Northcott, Brandon Faubert, Ryan Thomas, Stefan M. Pfister, Cristina E. Tognon, W. Brent Derry, V. Peter Collins, Martin G. McCabe, Amy Li, Olivier Delattre, Eric Jan, Barak Rotblat

Publikováno v: Leprivier, G, Remke, M, Rotblat, B, Dubuc, A, Mateo, A R F, Kool, M, Agnihotri, S, El-Naggar, A, Yu, B, Somasekharan, S P, Faubert, B, Bridon, G, Tognon, C E, Mathers, J, Thomas, R, Li, A, Barokas, A, Kwok, B, Bowden, M, Smith, S, Wu, X, Korshunov, A, Hielscher, T, Northcott, P A, Galpin, J D, Ahern, C A, Wang, Y, Mccabe, M, Collins, V P, Jones, R G, Pollak, M, Delattre, O, Gleave, M E, Jan, E, Pfister, S M, Proud, C G, Derry, W B, Taylor, M D & Sorensen, P H 2013, ' The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation ', Cell, vol. 153, no. 5, pp. 1064–1079 . https://doi.org/10.1016/j.cell.2013.04.055
Leprivier, G, Remke, M, Rotblat, B, Dubuc, A, Mateo, A R F, Kool, M, Agnihotri, S, El-Naggar, A, Yu, B, Somasekharan, S P, Faubert, B, Bridon, G, Tognon, C E, Mathers, J, Thomas, R, Li, A, Barokas, A, Kwok, B, Bowden, M, Smith, S, Wu, X, Korshunov, A, Hielscher, T, Northcott, P A, Galpin, J D, Ahern, C A, Wang, Y, Mccabe, M, Collins, V P, Jones, R G, Pollak, M, Delattre, O, Gleave, M E, Jan, E, Pfister, S M, Proud, C G, Derry, W B, Taylor, M D & Sorensen, P H 2013, ' The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation ', Cell, vol. 153, no. 5, pp. 1064–1079 . https://doi.org/10.1016/j.cell.2013.04.055, https://doi.org/10.1016/j.cell.2013.04.055

Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65eca3a246bf25ae9efc3287c833fc99
https://pubmed.ncbi.nlm.nih.gov/23763997

Absence of t(12;15) associated ETV6-NTRK3 fusion transcripts in pediatric acute leukemias

Autor: Stevan R. Knezevich, Joan Mathers, Angela J. Alessandri, Poul H. Sorensen, Kirk R. Schultz

Publikováno v: Medical and pediatric oncology. 37(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8da0457faaa65ca7db4fd72816ed434
https://pubmed.ncbi.nlm.nih.gov/11568912