First-in-Human Randomized Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the KDM1A Inhibitor Vafidemstat

Autor: Juan Manuel Ferrero-Cafiero, Rosa M. Antonijoan, Cesar Molinero, Tamara Maes, Maria Isabel Arevalo, Montse Puntes, Cristina Mascaró, Jimena Coimbra, Joan Martínez-Colomer, Carlos Buesa

Publikováno v: CNS Drugs
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
CNS DRUGS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Background Vafidemstat, an inhibitor of the histone lysine-specific demethylase KDM1A, corrects cognition deficits and behavior alterations in rodent models. Here, we report the results from the first-in-human trial of vafidemstat in healthy young an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9fea48ac368201b2b0b39aa0a7cb29
http://europepmc.org/articles/PMC7985749

Comparison of Peripheral and Central Effects of Single and Repeated Oral Dose Administrations of Bilastine, a New H1 Antihistamine

Autor: Manuel J. Barbanoj, Consuelo García-Gea, Román Valiente, Joan Martínez-Colomer, Rosa M. Antonijoan

Publikováno v: Journal of Clinical Psychopharmacology. 28:675-685

Peripheral anti-H1 and central nervous system (CNS) activities after single (day 1) and repeated (day 7) administrations of increasing doses of bilastine (BIL) were assessed in 20 healthy volunteers throughout a crossover, randomized, double-blind, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566dfd8c9cec2a2b501c789575593680
https://doi.org/10.1097/jcp.0b013e31818b2091

Comparison of Peripheral and Central Effects of Single and Repeated Oral Dose Administrations of Bilastine, a New H1 Antihistamine.

Autor: García-Gea, Consuelo, Martínez-Colomer, Joan, Antonijoan, Rosa M., Valiente, Román, Barbanoj, Manuel-José

Publikováno v: Journal of Clinical Psychopharmacology; Dec2008, Vol. 28 Issue 6, p675-685, 11p