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Akademický článek

Overuse of corticosteroids in patients with immune thrombocytopenia (ITP) between 2011 and 2017 in the United States

Autor: Adam Cuker, Joseph Tkacz, Janna Manjelievskaia, Jens Haenig, Joan Maier, James B Bussel

Publikováno v: eJHaem, Vol 4, Iss 2, Pp 350-357 (2023)

Abstract Corticosteroids (CSs) are standard first‐line therapy for immune thrombocytopenia (ITP). Prolonged exposure is associated with substantial toxicity; thus guidelines recommend avoidance of prolonged CS treatment and early use of second‐li

Externí odkaz: https://doaj.org/article/c5aeec6fd667419497965ccad805364e

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Treatment of immune thrombocytopenia with eltrombopag in patients who had and who had not received prior rituximab: post-hoc analysis of the EXTEND study

Autor: Raymond S.M. Wong, Miona Stankovic, Oliver Meyer, James B. Bussel, Joan Maier, Abderrahim Khelif, Mansoor N. Saleh

Publikováno v: British journal of haematology. 196(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbc25fc254dd96945f8b18cc13fd4d3
https://pubmed.ncbi.nlm.nih.gov/34458977

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Efficacy and Safety of Eltrombopag Combined with Cyclosporine As First-Line Therapy in Adults with Severe Acquired Aplastic Anemia: Results of the Interventional Phase 2 Single-Arm Soar Study

Autor: Ulrike Kriemler-Krahn, Régis Peffault de Latour, Jun Ho Jang, Mehmet Turgut, Lalita Norasetthada, Jens Haenig, Efreen Montaño Figueroa, Carlo Finelli, Carlos Vallejo, Rodrigo T. Calado, Phillip Scheinberg, Joan Maier

Publikováno v: Blood. 138:2174-2174

Background: Severe aplastic anemia (SAA) is a rare bone marrow failure disorder associated with significant morbidity and mortality. SAA is characterized by severe pancytopenia and a hypocellular ( Aims: To assess the efficacy and safety of ETB + CsA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58086ff825daddb357efbe58840ce98c
https://doi.org/10.1182/blood-2021-147733

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Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer

Autor: Luc Dirix, Arunava Chakravartty, Christophe Massard, Jean-Pascal Machiels, Kim N. Chi, Begoña Mellado, Sabine Turri, Joan Maier, Karim Fizazi, Denes Csonka, Gwenaelle Gravis, Johann S. de Bono, Alain C. Mita, Daniel Castellano

Publikováno v: European Journal of Cancer. 76:36-44

Background The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signalling axis and androgen receptor (AR) pathways exhibit reciprocal feedback regulation in phosphatase and tensin homologue (PTEN)-deficient metastatic castration-resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b03a6753f5c57edf38a75942ede9dce7
https://doi.org/10.1016/j.ejca.2017.01.024

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Corrigendum to 'Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer' [European Journal of Cancer 76 (2017) 36-44]

Autor: Johann S. de Bono, Alain C. Mita, Gwenaelle Gravis, Daniel Castellano, Christophe Massard, Luc Dirix, Begoña Mellado, Sabine Turri, Jean-Pascal Machiels, Kim N. Chi, Arunava Chakravartty, Karim Fizazi, Denes Csonka, Joan Maier

Publikováno v: European journal of cancer (Oxford, England : 1990). 81

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0935e3067967a37e124c901cbc67129b
https://pubmed.ncbi.nlm.nih.gov/28282611

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Eltrombopag and Cyclosporine as First-Line Therapy in Patients with Severe Acquired Aplastic Anemia: A Two-part, 5-year, Single-Arm, Multicenter, Open-label, Phase 2 Trial (SOAR)

Autor: Joan Maier, Carlo Finelli, Ozlem Ocak Arikan, Phillip Scheinberg, Jun-Ho Jang

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 17:S389-S390

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ba48d801b2969702f10a6f6dc667f66
https://doi.org/10.1016/j.clml.2017.07.242

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Treatment of Immune Thrombocytopenia (ITP) with Eltrombopag (EPAG) in Patients Who Did and Did Not Receive Prior Rituximab (Ritux): A Post-Hoc Analysis of the Extend Study

Autor: James B. Bussel, Mansoor N. Saleh, Raymond S.M. Wong, Oliver Meyer, Abderrahim Khelif, Miona Stankovic, Joan Maier

Publikováno v: Blood. 132:1152-1152

Background: ITP is an acquired autoimmune disorder. Second-line treatment options include EPAG, romiplostim (both stimulate platelet production), ritux (a monoclonal anti-CD20 antibody that causes temporary but complete depletion of peripheral B cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::397d2670c5be50432f57891c7016c20d
https://doi.org/10.1182/blood-2018-99-114694

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Trial in progress: An open-label, multicenter, phase 3b study to assess the safety and efficacy of midostaurin in patients (pts) aged ≥ 18 y with newly diagnosed (ND) FLT3-mutated acute myeloid leukemia (AML) who are eligible for 7+3 or 5+2 chemotherapy (chemo)

Autor: Adolfo Fuentes, Joan Maier, Anne Ruault, Ythier Deniau, Moez Ben Ali, Valerie Campello-Iddison, Laura Cuenot

Publikováno v: Journal of Clinical Oncology. 36:TPS7079-TPS7079

TPS7079Background: FLT3 mutations, found in ≈30% of pts with AML, are associated with a poor prognosis. Midostaurin is a multikinase inhibitor that targets FLT3 and other kinases involved in AML pa...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca9b209f41fff13fd63e8cf1954f1fc0
https://doi.org/10.1200/jco.2018.36.15_suppl.tps7079

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Safety and efficacy of buparlisib (BKM120) and chemotherapy in advanced, squamous non-small cell lung cancer (sqNSCLC): Results from the phase Ib/II BASALT-2 and BASALT-3 studies

Autor: Jaafar Bennouna, Enriqueta Felip, Diego Cortinovis, Arunava Chakravartty, Juergen Alt, Eric Scott Schaefer, Marie Chol, Alessandro Morabito, Alex A. Adjei, Francesco Grossi, Paola Aimone, Luis Paz-Ares, David Planchard, Joan Maier, Javier de Castro, Tommaso De Pas, Natasha B. Leighl, Christos Chouaid, Michael Thomas

Publikováno v: Journal of Clinical Oncology. 34:e20522-e20522

e20522Background: Phosphatidylinositol 3-kinase (PI3K) pathway activation may contribute to primary and secondary resistance to platinum (Pt)-based chemotherapy (CT) in sqNSCLC. The pan-PI3K inhibi...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41279514a5629b43fe311466ff6ff66d
https://doi.org/10.1200/jco.2016.34.15_suppl.e20522

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