Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joan M. Spellman"'
Autor:
Joan M. Spellman, Lori K. Weimer, Zhongyou Wei, Steven T. Miller, Daniel A. Gamache, John M. Yanni
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:349-361
The mucin secretagogue 15(S)-HETE was found to stimulate glycoprotein secretion in human ocular tissue at submicromolar concentrations in the present studies. Therefore, the ability of topically applied 15(S)-HETE to preserve corneal integrity was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38582453513422780e620ebf27ba8a5b
https://doi.org/10.1089/10807680260218515
https://doi.org/10.1089/10807680260218515
Publikováno v:
Acta Ophthalmologica Scandinavica. 78:10-15
Olopatadine is a human conjunctival mast cell stabilizer with antihistaminic activity. Ketotifen is an older molecule that possesses antihistaminic activity and is reported to have additional pharmacological properties. The interactions of these two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cf23e0774d43fdf294ce4197c5ffc3
https://doi.org/10.1034/j.1600-0420.2000.078s230010.x
https://doi.org/10.1034/j.1600-0420.2000.078s230010.x
Publikováno v:
Inflammation. 24:357-370
Nepafenac, the amide analog of 2-amino-3-benzoylbenzeneacetic acid (amfenac), was examined in preclinical models for its potential utility as a topical ocular anti-inflammatory agent. Diclofenac was selected as the reference compound. In contrast to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c98f30c455cd81904d2b5c751aeddd36
https://doi.org/10.1023/a:1007049015148
https://doi.org/10.1023/a:1007049015148
Publikováno v:
Inflammation. 24:371-384
Nepafenac, the amide analog of the NSAID amfenac, was examined in vitro for its bioactivation by ocular tissue components and its ability to permeate external ocular barriers. Rabbit tissues catalyzed a concentration-dependent conversion of nepafenac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a18f33fb0014c843e409a5a6fb17333c
https://doi.org/10.1023/a:1007001131987
https://doi.org/10.1023/a:1007001131987
Autor:
Daniel A. Gamache, Najam A. Sharif, Joan M. Spellman, John M. Yanni, Lori K. Weimer, Steven T. Miller
Publikováno v:
Acta Ophthalmologica Scandinavica. 77:33-37
Two important realizations about pathophysiological mechanisms involved in allergic conjunctivitis have led to novel drug discovery efforts and new topical ocular medications for prevention and treatment of this prevent allergic disease. The first of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa3699137aa28377915abcb6c8cd486
https://doi.org/10.1111/j.1600-0420.1999.tb01171.x
https://doi.org/10.1111/j.1600-0420.1999.tb01171.x
Autor:
Steven T. Miller, Daniel A. Gamache, John M. Yanni, Shouxi Xu, Joan M. Spellman, Najam A. Sharif
Publikováno v:
Annals of Allergy, Asthma & Immunology. 79:541-545
Background The concept of mast cell heterogeneity is well established. Recent data indicate that human conjunctival tissue mast cells and human connective tissue mast cells respond to various secretagogues in similar fashion. It is now recognized tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fe55b991b948f245f61b30e6eb7e1a
https://doi.org/10.1016/s1081-1206(10)63063-3
https://doi.org/10.1016/s1081-1206(10)63063-3
Autor:
Joan M. Spellman, Gustav Graff, S. Dan Dimitrijevich, Laura Smith Lang, Lori K. Weimer, John M. Yanni, Daniel A. Gamache
Publikováno v:
Ocular Immunology and Inflammation. 5:117-128
The production of cytokines by human conjunctival epithelial cells following stimulation was investigated. Primary cultures of human conjunctival epithelial cells were characterized by morphology and keratin expression. Cultured epithelial cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e89b6502805d66561b935d97bd05c1b
https://doi.org/10.3109/09273949709085060
https://doi.org/10.3109/09273949709085060
Publikováno v:
International Archives of Allergy and Immunology. 114:139-143
Mast cells have been identified in the choroid of numerous species including man. However, functional studies involving these human mast cells have not been reported. In the current studies, the secretory response of human choroidal mast cells to var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b233b24708fd04f4d18f22e73982ebc9
https://doi.org/10.1159/000237659
https://doi.org/10.1159/000237659
Publikováno v:
Ocular Immunology and Inflammation. 4:39-50
Human conjunctiva was enzymatically digested into monodispersed cell preparations using collagenase and hyaluronidase. The preparations were enriched for mast cells using Percoll gradient centrifugation prior to challenge with various secretagogues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71c0f9442d45d1a9338c545878bf03b
https://doi.org/10.3109/09273949609069126
https://doi.org/10.3109/09273949609069126
Autor:
Gustav Graff, Joan M. Spellman, L S Lang, D.W. Parnell, Lori K. Weimer, Steven T. Miller, Milton T. Brady, D.J. Stephens, John M. Yanni, Daniel A. Gamache
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 12:389-400
Olopatadine (AL-4943A; KW-4679) [(z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2 acetic acid hydrochloride] is an anti-allergic agent which inhibits mast cell mediator release and possesses histamine H1 receptor antagonist act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c11e46a79b5d5a81002e5be8bf4779b
https://doi.org/10.1089/jop.1996.12.389
https://doi.org/10.1089/jop.1996.12.389