Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joan M. Hedge"'
Autor:
Bridgett N. Hill, Katy N. Britton, Deborah L. Hunter, Jeanene K. Olin, Morgan Lowery, Joan M. Hedge, Bridget R. Knapp, Kimberly A. Jarema, Zachary Rowson, Stephanie Padilla
Publikováno v:
Neurotoxicology and Teratology. 96:107163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca0515e3aa4ac326def72a0aca235e9d
https://doi.org/10.1016/j.ntt.2023.107163
https://doi.org/10.1016/j.ntt.2023.107163
Autor:
Bridgett Hill, David Korest, D.L. Hunter, Joan M. Hedge, Stephanie Padilla, K.A. Jarema, Kayla D. Coldsnow
Publikováno v:
Neuromethods ISBN: 9781071616369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579435ece0d29e172ac3816dea51295b
https://doi.org/10.1007/978-1-0716-1637-6_15
https://doi.org/10.1007/978-1-0716-1637-6_15
Publikováno v:
Toxicological Sciences. 113:367-379
Triclosan (5-chloro-2-(2,4-dichlorophenoxy)-phenol) is a chlorinated phenolic antibacterial compound found in consumer products. In vitro human pregnane X receptor activation, hepatic phase I enzyme induction, and decreased in vivo total thyroxine (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4b8f75576710e2be2f707cf07fa446
https://doi.org/10.1093/toxsci/kfp271
https://doi.org/10.1093/toxsci/kfp271
Publikováno v:
International Journal of Toxicology. 28:382-391
Hypothyroxinemia in rats has been well documented as a result of exposure to polychlorinated biphenyls (PCBs). Hypothetical mechanisms include induction of hepatic catabolic enzymes and cellular hormone transporters, and/or interference with plasma t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3214466c2cbeef440796371a42c250ec
https://doi.org/10.1177/1091581809344631
https://doi.org/10.1177/1091581809344631
Publikováno v:
International Journal of Toxicology. 28:368-381
Thyroid hormone (TH) disrupting compounds interfere with both thyroidal and extrathyroidal mechanisms to decrease circulating thyroxine (T4). This research tested the hypothesis that serum T4 concentrations of rodents exposed to a mixture of both TH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1afdde2d37b103299e6df8b3c6cce1
https://doi.org/10.1177/1091581809341883
https://doi.org/10.1177/1091581809341883
Publikováno v:
Drug and Chemical Toxicology. 31:245-254
Thyroid alterations have been shown to occur following exposure to polybrominated diphenyl ether (PBDE) mixtures, possibly indicating that disruptions in thyroid hormone levels may underlie behavior deficits observed in animals following postnatal PB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078762d5470699e7b0333088bbfd2305
https://doi.org/10.1080/01480540701873194
https://doi.org/10.1080/01480540701873194
Publikováno v:
Neurotoxicology and teratology. 52
Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP) are organophosphorous flame retardants with widespread usage and human exposures through food, inhalation, and dust ingestion. They have been detected in human t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7987de82bf19564b3aa69cd3db79ca7
https://pubmed.ncbi.nlm.nih.gov/26300399
https://pubmed.ncbi.nlm.nih.gov/26300399
Autor:
Joan M. Hedge, Richard A. Carchman, Elena S. Craft, Jane Ellen Simmons, Kevin M. Crofton, W. Hans Carter, Chris Gennings, Michael J. DeVito
Publikováno v:
Environmental Health Perspectives
Endocrine disruption from environmental contaminants has been linked to a broad spectrum of adverse outcomes. One concern about endocrine-disrupting xenobiotics is the potential for additive or synergistic (i.e., greater-than-additive) effects of mix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696a2b76b854aff4156049c4bf808c9
https://doi.org/10.1289/ehp.8195
https://doi.org/10.1289/ehp.8195
Autor:
Mark J. Strynar, Rebecca L. McMahen, Charles E. Wood, Joan M. Hedge, David W. Herr, Nicholas Stewart, James L. Crooks, Danielle L. Freeborn, Denise K. MacMillan, Virginia C. Moser
Publikováno v:
Toxicology and applied pharmacology. 282(2)
There is increasing emphasis on the use of biomarkers of adverse outcomes in safety assessment and translational research. We evaluated serum biomarkers and targeted metabolite profiles after exposure to pesticides (permethrin, deltamethrin, imidaclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f45ba8d3f36c48121e34bf74740877e
https://pubmed.ncbi.nlm.nih.gov/25497286
https://pubmed.ncbi.nlm.nih.gov/25497286
Autor:
Joan M. Hedge, Michael W. Hornung, Steven O. Simmons, Katie B. Paul, Kevin M. Crofton, Daniel M. Rotroff
Publikováno v:
Chemical research in toxicology. 27(3)
High-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not currently available. Herein, we describe the development of a HTPS TPO inhibition assay. Rat thy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1905e40b62d303f33d197df128167a
https://pubmed.ncbi.nlm.nih.gov/24383450
https://pubmed.ncbi.nlm.nih.gov/24383450