Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Joan L. Weller"'
Autor:
Steven L. Coon, Sandra Goebbels, Shobi Veleri, David C. Klein, Margaret J. Ochocinska, Joan L. Weller, P. Michael Iuvone, Takahisa Furukawa, Nikita Pozdeyev, Estela Muñoz
Publikováno v:
Journal of Neurochemistry. 123:44-59
NeuroD1 encodes a basic helix-loop-helix transcription factor involved in the development of neural and endocrine structures, including the retina and pineal gland. To determine the effect of NeuroD1 knockout in these tissues, a Cre/loxP recombinatio
Autor:
David Allan Carter, Stephen L. Coon, David Sugden, David C. Klein, Diego Martin Bustos, Joan L. Weller, Michael J. Bailey, Morten Møller, Martin F. Rath
Publikováno v:
Cell and Tissue Research. 344:1-11
Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fol
Autor:
Michael J. Bailey, Martin F. Rath, Morten Møller, Joan L. Weller, David C. Klein, David Sugden, Jong-So Kim
Publikováno v:
Molecular and Cellular Endocrinology. 314:128-135
Dopamine plays diverse and important roles in vertebrate biology, impacting behavior and physiology through actions mediated by specific G-protein-coupled receptors, one of which is the dopamine receptor D4 (Drd4). Here we present studies on the >100
Autor:
Joan L. Weller, Morten Møller, Seth Blackshaw, Steven L. Coon, David C. Klein, Martin F. Rath, Jong So Kim
Publikováno v:
Journal of Neurochemistry. 110:756-764
Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland.
Autor:
Qiong Shi, Fabrice Morin, Ann Humphries, Morten Møller, Michael J. Bailey, David Allan Carter, Joan L. Weller, David Sugden, Peter J. Munson, Jong-So Kim, Pascaline Gaildrat, David C. Klein, Steven L. Coon, John B. Hogenesch, Martin F. Rath, Surajit Ganguly, Zoila G. Rangel, Ruben Baler
Publikováno v:
Journal of Biological Chemistry. 284:7606-7622
The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip® technology
Autor:
Sergio A. Hassan, Joan L. Weller, Surajit Ganguly, Jiri Pavlicek, David C. Klein, Steven L. Coon, Dan L. Sackett
Publikováno v:
Journal of Biological Chemistry. 283:14552-14558
Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Pineal AANAT activity increases at night in all vertebrates, resulting in increased melatonin production. This in
Publikováno v:
Journal of Neurochemistry. 47:678-686
Pineal cyclic AMP and cyclic GMP are regulated by norepinephrine (NE) acting through alpha 1- and beta-adrenoceptors. beta-Adrenergic stimulation appears to be an absolute requirement and alpha 1-adrenergic activation amplifies beta-adrenergic stimul
Autor:
Weiping Zheng, Dirk Schwarzer, David C. Klein, Aaron M. LeBeau, Joan L. Weller, Philip A. Cole
Publikováno v:
Journal of Biological Chemistry. 280:10462-10467
Large changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) in the pineal gland control the rhythmic production of the time-keeping hormone melatonin. The activity of AANAT reflects changes in the amount
Autor:
Joan L. Weller, Benoît Malpaux, Surajit Ganguly, David C. Klein, Anthony D. Ho, Philippe Chemineau
Publikováno v:
Proceedings of the National Academy of Sciences. 102:1222-1227
The nocturnal increase in circulating melatonin in vertebrates is regulated by the activity of arylalkylamine N -acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway (serotonin → N -acetylserotonin → melatonin). Large change