Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joan L. Press"'
Autor:
Carol A. Giorgetti, Lakshmi Venkataraman, Zheng Cao, Yves Denizot, Joan L. Press, Hansen Du, Ranjan Sen, Robert W. Maul, Patricia J. Gearhart
Publikováno v:
The Tokai journal of experimental and clinical medicine
The Tokai journal of experimental and clinical medicine, 2014, 211 (11), pp.2297-306
The Journal of Experimental Medicine
The Tokai journal of experimental and clinical medicine, 2014, 211 (11), pp.2297-306
The Journal of Experimental Medicine
Maul et al. show that proteins associated with variable gene hypermutation, such as Spt5 and AID, are recruited to the initiating form of RNA polymerase II specifically in cells activated in germinal centers but not in culture.
Variable (V) gene
Variable (V) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f380747443466293a76d86d51f2eff2a
https://hal.archives-ouvertes.fr/hal-01110436
https://hal.archives-ouvertes.fr/hal-01110436
Autor:
Joan L. Press
Publikováno v:
International Reviews of Immunology. 19:265-287
Neonatal animals are able to mount an effective immune response, both humoral and cellular, when immunized using conditions that maximize stimulation of antigen presenting cells, T cells, and B cells. In adults, somatic mutation is a key feature of t
Autor:
Carol A. Giorgetti, Joan L. Press
Publikováno v:
The Journal of Immunology. 161:6093-6104
Several mechanisms that diversify the adult immune repertoire, such as terminal deoxynucleotidyl transferase-dependent N region addition, are not available to the neonatal mouse. One important process that contributes to protective immunity in the ad
Publikováno v:
Molecular Immunology. 28:1217-1224
Our previous studies of the neonatal primary response to (T,G)-A--L showed that the majority of anti-(T,G)-A--L antibodies bind the copolymer L-Glu:L-Tyr (GT), share idiotypy (Id), and use the H10 germline VH gene from the VHJ558 family and a V kappa
Publikováno v:
Cell. 34:295-306
Monoclonal antibodies were used to identify and localize by immunoelectron microscopy epitopes on myosin isozymes. An antibody that reacts with an amino-terminal fragment of the myosin heavy chain maps on the myosin head 140 A distal to the head-rod
Publikováno v:
The Journal of Experimental Medicine
The nonimmune adult spleen contains at least two B-cell subpopulations. The majority of primary B cells express cell surface Ia determinants and have the capacity to give rise to IgG antibody-producing clones after T-cell dependent antigenic stimulat
Publikováno v:
The Journal of Immunology. 120:818-824
An immunochemical analysis of the kinetics of appearance of Ia antigens during embryonic development was performed. Ia antigens first appear on the surface of embryonic cells 11 days postconception and their expression between days 11 and 16 of gesta
Autor:
Joan L. Press, Norman R. Klinman
Publikováno v:
The Journal of Immunology. 111:829-835
The ability of antibody-forming cell precursors (B cells) obtained during murine development to participate in the splenic focus response to a hapten-protein conjugate was determined by the technique of adoptive cell transfer to irradiated, syngeneic
Publikováno v:
The Journal of Experimental Medicine
Experiments were carried out to test the validity of the hypothesis that postulated differences in the nature of the antigen receptors of primary and secondary B cells should be reflected in a greater specificity in primary B-cell stimulation (2). En
Autor:
Norman R. Klinman, Joan L. Press
Publikováno v:
The Journal of Experimental Medicine
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of prima