Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Joan Kyula"'
Autor:
Emmanuel C. Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T. Dillon, Anton Patrikeev, Martin McLaughlin, Lorna Grove, Shane Foo, Heba Soliman, Joao P. Barata, Joanna Marsden, Holly Baldock, Jim Gkantalis, Victoria Roulstone, Joan Kyula, Amy Burley, Lisa Hubbard, Malin Pedersen, Simon A. Smith, Eleanor Clancy-Thompson, Alan A. Melcher, Masahiro Ono, Antonio Rullan, Kevin J. Harrington
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Here, we show that combining ATR inhibition (ATRi)
Externí odkaz:
https://doaj.org/article/e03ce8982c174566b0e3ce1d9a1fbd10
Autor:
Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Over the past decade, cancer immunotherapies have revolutionized the treatment of melanoma; however, responses vary across patient populations. Recently, baseline tumor size has been identified as an independent prognostic factor for overa
Externí odkaz:
https://doaj.org/article/2760efb5528c442eb6992610bc801ce3
Autor:
Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Combination herpes simplex virus (HSV) oncolytic virotherapy and BRAF inhibitors (BRAFi) represent promising immunogenic treatments for BRAF mutant melanoma, but an improved understanding of the immunobiology of combinations is needed to i
Externí odkaz:
https://doaj.org/article/316204113b0e4019ac28423a26ae7cf2
Autor:
Simon Smith, Hormas Ghadially, Kevin J Harrington, Alan A Melcher, Isla Leslie, Eva Crespo-Rodriguez, Galabina Bozhanova, Emmanuel C Patin, Harriet Whittock, Martin McLaughlin, Malin Pedersen, James Harper, Pablo Nenclares, Heba Soliman, Magnus T Dillon, Lorna Grove, Davina Northcote, Holly Baldock, Gabriella Baker, Joan Kyula, Jeane Guevara
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell responses. Radiation and drug
Externí odkaz:
https://doaj.org/article/352213c6f2484a688ddb7a66accbad6a
Autor:
Henry G Smith, Kunzah Jamal, Jasbani HS Dayal, Tencho Tenev, Joan Kyula‐Currie, Naomi Guppy, Patrycja Gazinska, Victoria Roulstone, Gianmaria Liccardi, Emma Davies, Ioannis Roxanis, Alan A Melcher, Andrew J Hayes, Gareth J Inman, Kevin J Harrington, Pascal Meier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Abstract Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreov
Externí odkaz:
https://doaj.org/article/ebe09b78de1144a5ac46382d903dbfad
Autor:
Daniel B. Longley, Patrick G. Johnston, Dean A. Fennell, Susan Stokesberry, Joan Kyula, Donal M. Kelly, Sandra Van Schaeybroeck
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL/Apo-2L) has emerged as a promising anticancer agent. However, resistance to TRAIL is likely to be a major problem, and sensitization of cancer cells to TRAIL may therefore be an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45bce1d67630d66ee32bc58381f1e107
https://doi.org/10.1158/0008-5472.c.6497430
https://doi.org/10.1158/0008-5472.c.6497430
Autor:
Daniel B. Longley, Patrick G. Johnston, Dean A. Fennell, Susan Stokesberry, Joan Kyula, Donal M. Kelly, Sandra Van Schaeybroeck
Supplementary Figure 3 from Src and ADAM-17–Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771a4e22b5494372c8e40f256dd2410f
https://doi.org/10.1158/0008-5472.22374408
https://doi.org/10.1158/0008-5472.22374408
Autor:
Daniel B. Longley, Patrick G. Johnston, Dean A. Fennell, Susan Stokesberry, Joan Kyula, Donal M. Kelly, Sandra Van Schaeybroeck
Supplementary Figure 4 from Src and ADAM-17–Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897cc08494e7ed1138d518d5c847436b
https://doi.org/10.1158/0008-5472.22374405
https://doi.org/10.1158/0008-5472.22374405
Autor:
Daniel B. Longley, Patrick G. Johnston, Dean A. Fennell, Susan Stokesberry, Joan Kyula, Donal M. Kelly, Sandra Van Schaeybroeck
Supplementary Figure 1 from Src and ADAM-17–Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3e91db485c26dda29269f8dfa9d487
https://doi.org/10.1158/0008-5472.22374414
https://doi.org/10.1158/0008-5472.22374414
Autor:
Daniel B. Longley, Patrick G. Johnston, Dean A. Fennell, Susan Stokesberry, Joan Kyula, Donal M. Kelly, Sandra Van Schaeybroeck
Supplementary Figure 2 from Src and ADAM-17–Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d6a724a528b1ec317d1b6ac8d4e6a2
https://doi.org/10.1158/0008-5472.22374411.v1
https://doi.org/10.1158/0008-5472.22374411.v1