Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Joan K. Heath"'
Autor:
Christoph Grohmann, Charlene M. Magtoto, Joel R. Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A. Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S. Simpson, Hao Dong, Bridget Dorizzi, Annette V. Jacobsen, Emma Morrish, Natasha Silke, James M. Murphy, Joan K. Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume Lessene, John Silke, Rebecca Feltham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
tag-Targeted Protein Degrader (tTPD) systems are powerful tools for preclinical target validation. Here the authors extend the tTPD platform by developing NanoTACs that degrade NanoLuc tagged substrates and benchmark each tTPD system using an interch
Externí odkaz:
https://doaj.org/article/cbe3c5d3eff94f2bbdf917175c5d3791
Autor:
Esther J.Y. Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J. Majewski, Fan-Suo Geng, Jaber Firas, David C.S. Huang, Mark F. van Delft, Joan K. Heath
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 331-338 (2018)
Summary: Despite intensive efforts to optimize the process, reprogramming differentiated cells to induced pluripotent stem cells (iPSCs) remains inefficient. The most common combination of transcription factors employed comprises OCT4, KLF4, SOX2, an
Externí odkaz:
https://doaj.org/article/95bdd6f0ec9d4078820bfe33ba6cfd37
Autor:
Maria-Cristina Keightley, Duncan P. Carradice, Judith E. Layton, Luke Pase, Julien Y. Bertrand, Johannes G. Wittig, Aleksandar Dakic, Andrew P. Badrock, Nicholas J. Cole, David Traver, Stephen L. Nutt, Julia McCoey, Ashley M. Buckle, Joan K. Heath, Graham J. Lieschke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by
Externí odkaz:
https://doaj.org/article/3c95ab3a3ca641e6961f1263d836b9c2
Autor:
Emily K. Don, Tanya A. de Jong-Curtain, Karen Doggett, Thomas E. Hall, Benjamin Heng, Andrew P. Badrock, Claire Winnick, Garth A. Nicholson, Gilles J. Guillemin, Peter D. Currie, Daniel Hesselson, Joan K. Heath, Nicholas J. Cole
Publikováno v:
Biology Open, Vol 5, Iss 3, Pp 359-366 (2016)
Here we genetically characterise pelvic finless, a naturally occurring model of hindlimb loss in zebrafish that lacks pelvic fin structures, which are homologous to tetrapod hindlimbs, but displays no other abnormalities. Using a hybrid positional cl
Externí odkaz:
https://doaj.org/article/d83ac8d9ad514894a1c433251cfa8b7d
Autor:
Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H. Dashwood, Joan K. Heath, Matthias Ernst, Klaus-Peter Janssen
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 11, Pp 1361-1373 (2015)
Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great
Externí odkaz:
https://doaj.org/article/58867a4685854a29935bce90674df65b
Autor:
Benjamin B. Williams, Niall C. Tebbutt, Michael Buchert, Tracy L. Putoczki, Karen Doggett, Shisan Bao, Cameron N. Johnstone, Frederick Masson, Frederic Hollande, Antony W. Burgess, Andrew M. Scott, Matthias Ernst, Joan K. Heath
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 805-815 (2015)
The cells of the intestinal epithelium provide a selectively permeable barrier between the external environment and internal tissues. The integrity of this barrier is maintained by tight junctions, specialised cell-cell contacts that permit the absor
Externí odkaz:
https://doaj.org/article/532a052a19d24f2b9310bf3bc07af194
Autor:
Jake Shortt, Andy K. Hsu, Benjamin P. Martin, Karen Doggett, Geoffrey M. Matthews, Maria A. Doyle, Jason Ellul, Tina E. Jockel, Daniel M. Andrews, Simon J. Hogg, Andrea Reitsma, David Faulkner, P. Leif Bergsagel, Marta Chesi, Joan K. Heath, William A. Denny, Philip E. Thompson, Paul J. Neeson, David S. Ritchie, Grant A. McArthur, Ricky W. Johnstone
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1009-1019 (2014)
N-methyl-2-pyrrolidone (NMP) is a common solvent and drug vehicle. We discovered unexpected antineoplastic and immunomodulatory activity of NMP in a cMYC-driven myeloma model. Coincident to this, NMP was identified as an acetyllysine mimetic and cand
Externí odkaz:
https://doaj.org/article/ecf6a616961c4a08afd81383c8d12c65
Autor:
Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath
Publikováno v:
eLife. 12
The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70b413984aafbe43eb11b348a6ce5b2
https://doi.org/10.7554/elife.73407
https://doi.org/10.7554/elife.73407
Autor:
Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d726efe8c4dce834f4f87b8c0b905c
https://doi.org/10.7554/elife.73407.sa2
https://doi.org/10.7554/elife.73407.sa2
Autor:
Huijun Chen, Gregory J. Baillie, Richard B. Pearson, Elaine Sanij, Neil I. Bower, Marleen Gloger, Benjamin M. Hogan, Joan K. Heath, Kelly A. Smith, Maria Rondon-Galeano, Scott Paterson, Cas Simons, Stefan Schulte-Merker, Jiachen Xuan, Renae Skoczylas, Anne K. Lagendijk, Wolfram Goessling, Hannah Arnold, Ignaty Leshchiner, Stefanie Dudczig, Kazuhide S. Okuda, Katarzyna Koltowska, Elizabeth Mason
Publikováno v:
Nature Cell Biology. 23:1136-1147
The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network growth. Cellular proliferation is spatiotemporally regulated in developing vessels, but how this is orchestrated in differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87096e077c65239b117fd64280a1edcc
https://doi.org/10.1038/s41556-021-00784-w
https://doi.org/10.1038/s41556-021-00784-w