Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joan K. Brieland"'
Autor:
Xiaojie Wang, Sheng-Kwei Song, Joong H. Kim, Kathryn Trinkaus, Shawn P. O'Neil, Ying-Jr Chen, Joan K. Brieland, Tsang-Wei Tu, O'neal Janet M
Publikováno v:
NMR in Biomedicine. 26:1742-1750
Fingolimod (FTY720) is an orally available sphingosine-1-phosphate (S1P) receptor modulator reducing relapse frequency in patients with relapsing–remitting multiple sclerosis (RRMS). In addition to immunosuppression, neuronal protection by FTY720 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5110ada6f23f114d4c7478c7bd688c36
https://doi.org/10.1002/nbm.3012
https://doi.org/10.1002/nbm.3012
Autor:
Mark C. Sulavik, Ji-Young Kim, Rose Kelly, Allison Laura Choy, Roger J. Brideau, Poel Toni-Jo, Joanne Brodfuehrer, Gary E. Zurenko, Tong Zhu, Michael Dority, Cai Hongliang, Barbachyn Michael R, Joan K. Brieland, Thomas Richard C, Frederick E. Boyer, Michael R. Dermyer, Martin Joseph P, Michael D. Huband, Alan P. Brown, Daniel E. Ross, Debra Hanna, Laura A. Skerlos, Robert C. Gadwood, Wade J. Adams, Paul J. Pagano, Aristoff Paul A, Christopher Huber, J.V.N. Vara Prasad, Charles W. Ford
Publikováno v:
Journal of Medicinal Chemistry. 50:5886-5889
Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9719ee4eadbecc05b31ebef68614436
https://doi.org/10.1021/jm070708p
https://doi.org/10.1021/jm070708p
Autor:
Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf8a8aa89569f777c79f4224db99ed
https://doi.org/10.1016/j.bmcl.2007.05.083
https://doi.org/10.1016/j.bmcl.2007.05.083
Autor:
Luping Wu, Daniel E. Ross, Steve M. Swaney, Eva E. Nagiec, John G. Chosay, Karen L. Leach, Joan K. Brieland
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:3896-3902
The oxazolidinones are a relatively new structural class of antibacterial agents that act by inhibiting bacterial protein synthesis. The oxazolidinones inhibit mitochondrial protein synthesis, as shown by [ 35 S]methionine incorporation into intact r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14743796a8d1177018a96fc3f7616638
https://doi.org/10.1128/aac.49.9.3896-3902.2005
https://doi.org/10.1128/aac.49.9.3896-3902.2005
Autor:
Jonathan M. Gilbert, Sandra Zurawski, Theresa Clifford, Ted T. Kung, Stephen D. Hurst, Sylvia Kwan, Craig Jackson, Brian W. P. Seymour, Tony Muchamuel, Satish Menon, Gerard Zurawski, Joan K. Brieland, Daniel M. Gorman, Richard W. Chapman, Robert L. Coffman
Publikováno v:
The Journal of Immunology. 169:443-453
We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in vitro screening approaches, we have characterized the activity of these new molecules by direct in vivo analysis and hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274161cd9aa50d83eb0cbda7ca4f3838
https://doi.org/10.4049/jimmunol.169.1.443
https://doi.org/10.4049/jimmunol.169.1.443
Autor:
Craig Jackson, Anne O'Garra, Joan K. Brieland, Rob Kastelein, Judy Halpern, Reno Debets, Tatyana Churakova, Fred Menzel, Roberta S. Hare, Stephen D. Hurst, Anthony Cacciapuoti, David Loebenberg, John S. Abrams, Tony Muchamuel
Publikováno v:
Infection and Immunity. 69:1554-1560
Cytokine networking in the lung in response to inhaledAspergillus fumigatuswas assessed using a murine model of primary pulmonary aspergillosis in immunocompetent Crl:CF-1 mice. Inhalation of virulentA. fumigatus(6 × 106CFU) resulted in the inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363de70012f1e78a686b03e2d3fd8689
https://doi.org/10.1128/iai.69.3.1554-1560.2001
https://doi.org/10.1128/iai.69.3.1554-1560.2001
Publikováno v:
Immunopharmacology. 48:249-252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31982fda899694bc86d69fbf2876b9a
https://doi.org/10.1016/s0162-3109(00)00235-6
https://doi.org/10.1016/s0162-3109(00)00235-6
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:1333-1336
Legionella pneumophila, the causative agent of Legionnaires' disease, is a facultative intracellular pathogen of mononuclear phagocytic cells (7, 9, 10). While all persons are susceptible to legionellosis, the frequency and severity of the disease ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b648f6f0620175b37265de7ae886595
https://doi.org/10.1128/aac.44.5.1333-1336.2000
https://doi.org/10.1128/aac.44.5.1333-1336.2000
Publikováno v:
Microbial Pathogenesis. 25:291-306
Alveolar epithelial cells, which constitute the majority of the alveolar surface, may represent a potential niche for intracellular replication ofLegionella pneumophilathat has been largely overlooked. We examined the phenotypes of a bank of 121 macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e976a818ed4683c3e157467f69c9793f
https://doi.org/10.1006/mpat.1998.0237
https://doi.org/10.1006/mpat.1998.0237
Publikováno v:
Infection and Immunity. 65:4892-4896
The potential role of inhaled protozoa as a niche for intrapulmonary replication of Legionella pneumophila was investigated in vivo with mutant strains of L. pneumophila which have reduced virulence for the amoeba Hartmannella vermiformis. L. pneumop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeeadddff10d5b3aa3a715b3ef363513
https://doi.org/10.1128/iai.65.11.4892-4896.1997
https://doi.org/10.1128/iai.65.11.4892-4896.1997