RhoA/ROCK2 signalling is enhanced by PDGF‐AA in fibro‐adipogenic progenitor cells: implications for Duchenne muscular dystrophy

Autor: Esther Fernández‐Simón, Xavier Suárez‐Calvet, Ana Carrasco‐Rozas, Patricia Piñol‐Jurado, Susana López‐Fernández, Gemma Pons, Joan Josep Bech Serra, Carolina de laTorre, Noemí deLuna, Eduard Gallardo, Jordi Díaz‐Manera

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1373-1384 (2022)

Abstract Background The lack of dystrophin expression in Duchenne muscular dystrophy (DMD) induces muscle fibre and replacement by fibro‐adipose tissue. Although the role of some growth factors in the process of fibrogenesis has been studied, pathw

Externí odkaz: https://doaj.org/article/8197b823bac74496a80deffb2f41763a

ANTITUMORAL ACTIVITY OF THE NOVEL BTK INHIBITOR TG‐1701 IS ASSOCIATED WITH DISRUPTION OF IKAROS SIGNALING AND IMPROVEMENT OF ANTI‐CD20 THERAPY IN B‐CELL NON‐HODGKIN LYMPHOMA

Autor: Eva Musulen, Emmanuel Normant, C De la Torre, Meritxell Vinyoles, Juliana Carvalho Santos, N Profitos-Peleja, H.P. Miskin, Diana Reyes-Garau, Miranda Fernández-Serrano, Pedro Blecua, Joan Josep Bech-Serra, Gaël Roué, Manel Esteller, Pablo Menendez, Francesc Bosch, Marcelo Lima Ribeiro, Marc Armengol

Publikováno v: Hematological Oncology. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::852def8f4049deed40afcef7d3136efa
https://doi.org/10.1002/hon.153_2880

Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis

Autor: Antonio Gentilella, Johannes Zuber, Marguerite-Marie Le Pannérer, Carolina De La Torre, Michael Maher, René Winkler, Carolina Martínez Herráez, Lurdes Zamora, Joan Josep Bech-Serra, Matthias Muhar, Nigel Brooks, Marcus Buschbeck, Katharina Götze, Michaela Fellner, Mark van der Garde, Philipp Rathert, Raquel Casquero, Jeannine Diesch

Publikováno v: Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

The nucleotide analogue azacitidine (AZA) is currently the best treatment option for patients with high-risk myelodysplastic syndromes (MDS). However, only half of treated patients respond and of these almost all eventually relapse. New treatment opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0435f0addf061fc6e532fd6d31125fa2
https://ddd.uab.cat/record/270585

SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast

Autor: Ines Calabria, Judith Vinaixa, Concha Gil, Soraya Játiva, Silvia Barceló-Batllori, Martin R. Larsen, Ethel Queralt, João P. G. L. M. Rodrigues, Carolina de LaTorre, María Luisa Hernáez, Joan-Josep Bech-Serra, Barbara Baro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Baro, B, Játiva, S, Calabria, I, Vinaixa, J, Bech-Serra, J-J, de LaTorre, C, Rodrigues, J, Hernáez, M L, Gil, C, Barceló-Batllori, S, Larsen, M R & Queralt, E 2018, ' SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast ', GigaScience, vol. 7, no. 5, giy047 . https://doi.org/10.1093/gigascience/giy047
GigaScience
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

18 páginas, 5 figuras, 1 tabla
Background: Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2ACdc55 phosphatase has been extensively r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e49adbe03cb62da24c3b0b0fc26b71b
http://hdl.handle.net/10261/272296

Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human μ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines

Autor: Jean Marie Zajac, Gemma Arsequell, Franck Talmont, Francesc Canals, Mònica Rosa, Gregorio Valencia, Joan Josep Bech-Serra

Publikováno v: Journal of Proteome Research. 14:3162-3173

Human μ-opioid receptor (hMOR) is a class-A G-protein-coupled receptor (GPCR), a prime therapeutic target for the management of moderate and severe pain. A chimeric form of the receptor has been cocrystallized with an opioid antagonist and resolved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05fcc3ff7303194be81cd6ca00abd18
https://doi.org/10.1021/acs.jproteome.5b00104