Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joan J. Subrath"'
Autor:
Ying-Xian Pan, Andras Varadi, Gavril W. Pasternak, Joan J. Subrath, Amanda Hunkele, Susruta Majumdar, Rajendra Uprety, Steven G. Grinnell
Publikováno v:
Cell Mol Neurobiol
Mu opioid receptors (MOR-1) mediate the biological actions of clinically used opioids such as morphine, oxycodone, and fentanyl. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, generating multiple splice variants. One ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd285a387e4ab2ac4374c638883eab5a
https://doi.org/10.1007/s10571-020-00867-6
https://doi.org/10.1007/s10571-020-00867-6
Autor:
Samuel T. Slocum, Vsevolod Katritch, Rajendra Uprety, Joan J. Subrath, Jay P. McLaughlin, Gavril W. Pasternak, Ying Xian Pan, Amanda Hunkele, Valerie Le Rouzic, Melissa Nelson, Steven G. Grinnell, Abdelfattah Faouzi, András Váradi, Saheem A. Zaidi, Bryan L. Roth, Shainnel O. Eans, Balázs Varga, Elizaveta Kulko, Abdullah Allaoa, Tao Che, Susruta Majumdar, Sarah M Bernhard, Jonathan A. Javitch, Chloe A. Simons
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94dd6471e3351c062c3cc8a9d52004b
http://europepmc.org/articles/PMC7909954
http://europepmc.org/articles/PMC7909954
Autor:
Gavril W. Pasternak, Abdelfattah Faouzi, Bryan L. Roth, Amanda Hunkele, Steven G. Grinnell, Susruta Majumdar, Valerie Le Rouzic, Melissa Nelson, Sarah M Bernhard, Chloe A. Simons, Shainnel O. Eans, Samuel T. Slocum, Rajendra Uprety, Joan J. Subrath, András Váradi, Tao Che, Ying Xian Pan, Jonathan A. Javitch, Elizaveta Kulko, Vsevolod Katritch, Abdullah Allaoa, Saheem A. Zaidi, Balázs Varga, Jay P. McLaughlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf306e63c447f91f658560d8a55c64b
https://doi.org/10.7554/elife.56519.sa2
https://doi.org/10.7554/elife.56519.sa2
Autor:
Jessica M. Medina, Joan J. Subrath, Márton Richárd Szabó, Jay P. McLaughlin, Susruta Majumdar, Steven G. Grinnell, Gina F. Marrone, Sanjay Kalra, András Váradi, Jeremy Pagirsky, Ying-Xian Pan, Attila Borics, Jin Xu, Travis C. Palmer, Gavril W. Pasternak, Ankita Narayan, Valerie Le Rouzic, Shainnel O. Eans, Evelyn Warner, Amanda Hunkele
Publikováno v:
Journal of Medicinal Chemistry. 59:8381-8397
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology. Herein, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94a35e55b45ec92a90c2a69f4766534
https://doi.org/10.1021/acs.jmedchem.6b00748
https://doi.org/10.1021/acs.jmedchem.6b00748
Autor:
Jay P. McLaughlin, András Váradi, Gavril W. Pasternak, Michelle L. Ganno, Shainnel O. Eans, Valerie Le Rouzic, Gina F. Marrone, Susruta Majumdar, Amanda Hunkele, Joan J. Subrath
Publikováno v:
ACS Chemical Neuroscience. 6:1813-1824
3-Iodobenzoyl naltrexamine (IBNtxA) is a potent analgesic belonging to the pharmacologically diverse 6β-amidoepoxymorphinan group of opioids. We present the synthesis and pharmacological evaluation of five analogs of IBNtxA. The scaffold of IBNtxA w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c1b69f364444cf219f1893c9699003
https://doi.org/10.1021/acschemneuro.5b00153
https://doi.org/10.1021/acschemneuro.5b00153
Autor:
Travis C. Palmer, Gavril W. Pasternak, Nathan Haselton, András Váradi, Valerie Le Rouzic, Joan J. Subrath, Attila Borics, Susruta Majumdar, Amanda Hunkele, Gina F. Marrone, Daniel Afonin
Publikováno v:
ACS Chemical Neuroscience. 6:1570-1577
We report a novel approach to synthesize carfentanil amide analogues utilizing the isocyanide-based four-component Ugi multicomponent reaction. A small library of bis-amide analogues of carfentanil was created using N-alkylpiperidones, aniline, propi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4325f9563198222495feb34e0262e2a9
https://doi.org/10.1021/acschemneuro.5b00137
https://doi.org/10.1021/acschemneuro.5b00137
Autor:
András Váradi, Paula R. Notis, Joan J. Subrath, Indrajeet Sharma, Daniel Afonin, Chunhua Hu, Gabriel N. Redel-Traub, Travis C. Palmer, Gavril W. Pasternak, Susruta Majumdar
Publikováno v:
Organic Letters
The formation of an unexpected heterocyclic scaffold, a benzoxazole, in a three-component reaction between a ketone, isocyanide, and 2-aminophenol was encountered. This reaction involved a benzo[b][1,4]oxazine intermediate resulting from intramolecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3afe19e11d95fb4b03ec38e20bc76e6
https://doi.org/10.1021/ol500328t
https://doi.org/10.1021/ol500328t
Autor:
Gavril W. Pasternak, Daniel Afonin, Travis C. Palmer, Gabriel N. Redel-Traub, Chunhua Hu, Paula R. Notis, Joan J. Subrath, Indrajeet Sharma, Susruta Majumdar, András Váradi
Publikováno v:
ChemInform. 45
Nearly any aryl or alkyl isocyanide is also effective in transforming (I) to (IV) in low to very good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694815852f9664df0561f35b1f2f64f2
https://doi.org/10.1002/chin.201435146
https://doi.org/10.1002/chin.201435146
Autor:
Susruta Majumdar, Gavril W. Pasternak, Nathan Haselton, Ying-Xian Pan, Julie Ocampo, Anna R. Pasternak, Steven G. Grinnell, Kuni Nagakura, Lisa Polikar, Maxim Burgman, Valerie Le Rouzic, Joan J. Subrath
3-Iodobenzoylnaltrexamide 1 (IBNtxA) is a potent analgesic acting through a novel receptor target that lack many side-effects of traditional opiates composed, in part, of exon 11-associated truncated six transmembrane domain MOR-1 (6TM/E11) splice va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88f0f108e54f15be05eb51405ae7ed3
https://europepmc.org/articles/PMC3412067/
https://europepmc.org/articles/PMC3412067/