Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Joan J. Guinovart"'
Autor:
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112578- (2023)
Summary: Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, sug
Externí odkaz:
https://doaj.org/article/9cb3c9ca6c2240379dd61634e40c1c8c
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Increased liver glycogen content has been shown to reduce food intake, attenuate obesity, and improve glucose tolerance in a mouse model of high-fat diet (HFD)-induced obesity. Here we studied the contribution of liver glycogen to the regulation of o
Externí odkaz:
https://doaj.org/article/bed727cf958a4fd89b2c166e9eee1e48
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2574 (2023)
Many lines of evidence demonstrate a correlation between liver glycogen content and food intake. We previously demonstrated that mice overexpressing protein targeting to glycogen (PTG) specifically in the liver—which have increased glycogen content
Externí odkaz:
https://doaj.org/article/14a89ee440ed46869328a42267cb3763
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105173- (2021)
Abstract.Lafora disease (LD) is a fatal adolescence-onset neurodegenerative condition. The hallmark of LD is the accumulation of aberrant glycogen aggregates called Lafora bodies (LBs) in the brain and other tissues. Impeding glycogen synthesis from
Externí odkaz:
https://doaj.org/article/bd710317334443dabd1697dfb772a928
Autor:
Jordi Duran, Agnès Gruart, Olga Varea, Iliana López-Soldado, José M. Delgado-García, Joan J. Guinovart
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Since brain glycogen is stored mainly in astrocytes, the role of this polysaccharide in neurons has been largely overlooked. To study the existence and relevance of an active neuronal glycogen metabolism in vivo, we generated a mouse model lacking gl
Externí odkaz:
https://doaj.org/article/12e01ca89e44435d935480bda2c9aead
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Autor:
Felipe Slebe, Federico Rojo, Maria Vinaixa, Mar García-Rocha, Giorgia Testoni, Marc Guiu, Evarist Planet, Sara Samino, Enrique J. Arenas, Antoni Beltran, Ana Rovira, Ana Lluch, Xavier Salvatella, Oscar Yanes, Joan Albanell, Joan J. Guinovart, Roger R. Gomis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Deregulation of lipid metabolism in cancer cells is critical to the maintenance of certain malignant features. Here, the authors show that the proliferation of breast cancer cells depends upon the extracellular activity of the endothelial lipase enzy
Externí odkaz:
https://doaj.org/article/10556d75bea04703ad93a919ca77d8fc
Publikováno v:
Metabolites, Vol 2, Iss 4, Pp 775-795 (2012)
Several metabolomic software programs provide methods for peak picking, retention time alignment and quantification of metabolite features in LC/MS-based metabolomics. Statistical analysis, however, is needed in order to discover those features signi
Externí odkaz:
https://doaj.org/article/44316bc0fb5e476da531531deedd9912
Autor:
Gokhan Uruk, Sinem Yilmaz-Ozcan, Canan Cakir-Aktas, Aslihan Taskiran-Sag, Buket Donmez-Demir, Jordi Duran, Joan J. Guinovart, Hulya Karatas-Kurşun, Turgay Dalkara, Muge Yemisci
Ischemic stroke results in sudden blood flow cessation, thus, unmet energy requirements. Although the clotted artery can be recanalized and blood flow is restored, brain perfusion may not be fully attained due to microvascular constrictions. Under gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8527cefbd893f01b6a6c1e59f7cc7f5f
https://doi.org/10.1101/2022.08.24.505172
https://doi.org/10.1101/2022.08.24.505172
Autor:
Jordi Duran, Giorgia Testoni, Elena Lopez-Rodriguez, María Isabel Hernández-Álvarez, Joan J. Guinovart, Mònica Aguilera, Neus Prats, Bárbara Olmeda, Jesús Pérez-Gil
Publikováno v:
Human Molecular Genetics. 29:3554-3565
The glycogenin knockout mouse is a model of Glycogen Storage Disease type XV. These animals show high perinatal mortality (90%) due to respiratory failure. The lungs of glycogenin-deficient embryos and P0 mice have a lower glycogen content than that
Autor:
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Publikováno v:
SSRN Electronic Journal.