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pro vyhledávání: '"Joan I. Post"'
Autor:
Philip N. Vrkljan, Kenneth E. Neet, Mark Solc, Gail Lawrance, Igor L. Shamovsky, Richard J. Riopelle, Joan I. Post, Suzanne M. Dostaler, Gregory M. Ross, Sang B. Woo
Publikováno v:
Journal of Neurochemistry. 78:515-523
It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905db55da3d8786bea8b760b41c6c894
https://doi.org/10.1046/j.1471-4159.2001.00427.x
https://doi.org/10.1046/j.1471-4159.2001.00427.x
Publikováno v:
Neurotoxicology. 23(4-5)
Genetic, neurochemical, and environmental factors have been implicated in neurodegenerative disease, and a combination of these factors is likely responsible for disease onset and progression. Environmental toxicants implicated in Parkinson’s disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d3c6ba2d3bceb978bbc801bb959bc6
https://pubmed.ncbi.nlm.nih.gov/12428727
https://pubmed.ncbi.nlm.nih.gov/12428727
Publikováno v:
Neuroscience letters. 259(2)
We have previously provided evidence that two transition metal cations, Zn2+ and Cu2+, can alter the conformation of nerve growth factor (NGF), rendering it unable to bind to its receptors or to activate signal transduction pathways. In the present s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6277afc62649a96f67f753ce3f927814
https://pubmed.ncbi.nlm.nih.gov/10025571
https://pubmed.ncbi.nlm.nih.gov/10025571