Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joan Holgate"'
Autor:
Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L Patkar, Vincent Tam, Arnauld Belmer, Selena E Bartlett
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150270 (2016)
Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus
Externí odkaz:
https://doaj.org/article/370bb3027fd94028ac54662fe58c1d74
Autor:
Susmita Chatterjee, Nathan Santos, Joan Holgate, Carolina L Haass-Koffler, F Woodward Hopf, Viktor Kharazia, Henry Lester, Antonello Bonci, Selena E Bartlett
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68300 (2013)
Human genetic association studies have shown gene variants in the α5 subunit of the neuronal nicotinic receptor (nAChR) influence both ethanol and nicotine dependence. The α5 subunit is an accessory subunit that facilitates α4* nAChRs assembly in
Externí odkaz:
https://doaj.org/article/6f289e2fd0f94888a0c610893ebf2350
Autor:
Pia Steensland, Jeffrey A Simms, Carsten K Nielsen, Joan Holgate, Jade J Bito-Onon, Selena E Bartlett
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The current obesity epidemic is thought to be partly driven by over-consumption of sugar-sweetened diets and soft drinks. Loss-of-control over eating and addiction to drugs of abuse share overlapping brain mechanisms including changes in motivational
Externí odkaz:
https://doaj.org/article/c204452d1f01448988a70fdd8108813e
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 154:175-185
Purpose This study aimed to assess the activity of controlled release nicotine from dry powder inhaler formulation via locomotor activity of C57BL/6 mice. Methods To achieve this we built a nose-only inhalation device for pulmonary administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c33c746126146ce48669d8397efa9ce
https://doi.org/10.1016/j.ejpb.2020.07.011
https://doi.org/10.1016/j.ejpb.2020.07.011
Publikováno v:
Addiction Biology. 24:652-663
Repeated cycles of binge-like alcohol consumption and abstinence change the activity of several neurotransmitter systems. Some of these changes are consolidated following prolonged alcohol use and are thought to play an important role in the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a7ef5e0005ed164f6906237e8ca89
https://doi.org/10.1111/adb.12630
https://doi.org/10.1111/adb.12630
Autor:
Matthew J. Fogarty, Omkar L. Patkar, Arnauld Belmer, Masroor Shariff, Michael M. Morgan, Josephine R. Tarren, Mark C. Bellingham, Joan Holgate, Selena E. Bartlett, Paul M. Klenowski
Publikováno v:
Addiction Biology. 22:679-691
Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. Consequently, there is a critical need for improved pharmacotherapeutic strategies to manage alcohol use disorders (AUDs). Previous st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1acb55813b6ba35bd4d27a982255826
https://doi.org/10.1111/adb.12359
https://doi.org/10.1111/adb.12359
Publikováno v:
Brain Sciences
Brain Sciences; Volume 8; Issue 4; Pages: 70
Brain Sciences; Volume 8; Issue 4; Pages: 70
Background: The mechanisms leading from traumatic stress to social, emotional and cognitive impairment and the development of mental illnesses are still undetermined and consequently there remains a critical need to develop therapies for preventing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9b8970d2e1351bbbfb5ca7325c3142
http://europepmc.org/articles/PMC5924406
http://europepmc.org/articles/PMC5924406
Autor:
Joan Holgate, Selena E. Bartlett
Publikováno v:
Brain Sciences, Vol 5, Iss 3, Pp 258-274 (2015)
Brain Sciences
Brain Sciences
Stress is a major driving force in alcohol use disorders (AUDs). It influences how much one consumes, craving intensity and whether an abstinent individual will return to harmful alcohol consumption. We are most vulnerable to the effects of stress du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e778033eef7d7d750bc9f28b46577e
https://doi.org/10.3390/brainsci5030258
https://doi.org/10.3390/brainsci5030258
Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice
Publikováno v:
Brain and Behavior
Background Factors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment. While we cannot control the genes we inherit, we can modify our environment. Understanding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270b99a2b439408105c7aa9fe70c788f
https://doi.org/10.1002/brb3.767
https://doi.org/10.1002/brb3.767
Publikováno v:
Frontiers in Behavioral Neuroscience
Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817f20004c796d0d052a47bb0bef34ef
https://pubmed.ncbi.nlm.nih.gov/28275340
https://pubmed.ncbi.nlm.nih.gov/28275340