Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Joan Heller Brown"'
Autor:
Matthias Dewenter, Tilmann Seitz, Julia H. Steinbrecher, B. Daan Westenbrink, Haiyun Ling, Stephan E. Lehnart, Xander H.T. Wehrens, Johannes Backs, Joan Heller Brown, Lars S. Maier, Stefan Neef
Publikováno v:
ESC Heart Failure, Vol 11, Iss 4, Pp 2191-2199 (2024)
Abstract Aims Hyperactivity of Ca2+/calmodulin‐dependent protein kinase II (CaMKII) has emerged as a central cause of pathologic remodelling in heart failure. It has been suggested that CaMKII‐induced hyperphosphorylation of the ryanodine recepto
Externí odkaz:
https://doaj.org/article/811ff42f2bd046b0b243e4d8ccb5b35b
Autor:
Olga Meiri Chaim, Shunichiro Miki, Briana C. Prager, Jianhui Ma, Anthony Y. Jeong, Jacqueline Lara, Nancy K. Tran, Jeffrey M. Smith, Jeremy N. Rich, J. Silvio Gutkind, Shigeki Miyamoto, Frank B. Furnari, Joan Heller Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In silico interrogation of glioblastoma (GBM) in The Cancer Genome Atlas (TCGA) revealed upregulation of GNA12 (Gα12), encoding the alpha subunit of the heterotrimeric G-protein G12, concomitant with overexpression of multiple G-protein cou
Externí odkaz:
https://doaj.org/article/e419c358a7d24206a72d5cdef498840f
Autor:
Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun‐Liang Guan
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 607-629 (2022)
Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1‐associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying mechanism is unknow
Externí odkaz:
https://doaj.org/article/c09dd010f79f452da1fe73b87f2bdbde
Autor:
Alex Moshensky, Cameron S Brand, Hasan Alhaddad, John Shin, Jorge A Masso-Silva, Ira Advani, Deepti Gunge, Aditi Sharma, Sagar Mehta, Arya Jahan, Sedtavut Nilaad, Jarod Olay, Wanjun Gu, Tatum Simonson, Daniyah Almarghalani, Josephine Pham, Samantha Perera, Kenneth Park, Rita Al-Kolla, Hoyoung Moon, Soumita Das, Min Kwang Byun, Zahoor Shah, Youssef Sari, Joan Heller Brown, Laura E Crotty Alexander
Publikováno v:
eLife, Vol 11 (2022)
While health effects of conventional tobacco are well defined, data on vaping devices, including one of the most popular e-cigarettes which have high nicotine levels, are less established. Prior acute e-cigarette studies have demonstrated inflammator
Externí odkaz:
https://doaj.org/article/8207b0427de34b17bcd695958b0fcc0b
Autor:
David M. Calcagno, Claire Zhang, Avinash Toomu, Kenneth Huang, Van K. Ninh, Shigeki Miyamoto, Aaron D. Aguirre, Zhenxing Fu, Joan Heller Brown, Kevin R. King
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background Neutrophils are thought to be short‐lived first responders to tissue injuries such as myocardial infarction (MI), but little is known about their diversification or dynamics. Methods and Results We permanently ligated the left anterior d
Externí odkaz:
https://doaj.org/article/a9ad33dd524d4732a6e95105d9b3c812
Autor:
Jason Z Zhang, Andy H Nguyen, Shigeki Miyamoto, Joan Heller Brown, Andrew D McCulloch, Jin Zhang
Publikováno v:
PLoS Biology, Vol 18, Iss 9, p e3000866 (2020)
The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression. Many signal transduction pathways activate RhoA-for instance, Gαq-coupled Hi
Externí odkaz:
https://doaj.org/article/0ebb54bacf2e4652ac3dc47d3752c53f
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-10 (2017)
Abstract Background Sphingosine 1-phosphate (S1P) signals through G protein-coupled receptors to elicit a wide range of cellular responses. In CNS injury and disease, the blood-brain barrier is compromised, causing leakage of S1P from blood into the
Externí odkaz:
https://doaj.org/article/3f520184a7ad48c68af6f97ad654d349
Autor:
Adam J Pollak, Canzhao Liu, Aparna Gudlur, Joshua E Mayfield, Nancy D Dalton, Yusu Gu, Ju Chen, Joan Heller Brown, Patrick G Hogan, Sandra E Wiley, Kirk L Peterson, Jack E Dixon
Publikováno v:
eLife, Vol 7 (2018)
Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca2+ signaling have been shown to be phosphorylated, the biochemical and physiological ro
Externí odkaz:
https://doaj.org/article/ecc097f1b4894d6997ab24d9a2cc0ed7
Autor:
Mario G. Pavez-Giani, Pablo I. Sánchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Harmen G. Booij, Paula Giraldo, Silke U. Oberdorf-Maass, Kirsten T. Nijholt, Salva R. Yurista, Hendrik Milting, Peter van der Meer, Rudolf A. de Boer, Joan Heller Brown, Herman W. H. Sillje, B. Daan Westenbrink
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4427 (2021)
ATPase inhibitory factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial dysfunction and pathol
Externí odkaz:
https://doaj.org/article/01bafd16ce6d445caa2f982ee157eef2
Autor:
Juan Manuel Ortiz-Sanchez, Sara E Nichols, Jacqueline Sayyah, Joan Heller Brown, J Andrew McCammon, Barry J Grant
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40809 (2012)
Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activit
Externí odkaz:
https://doaj.org/article/2196640ae9314e6fb44c1b9cde9e781b