Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joan H.Q. Shen"'
Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers
Autor:
Julia Blievernicht, Jae-Gook Shin, Lang Li, Ulrich M. Zanger, Doo-Yeoun Cho, David A. Flockhart, Joan H.Q. Shen, Zeruesenay Desta, Todd C. Skaar, Suzanne Lemler, Kwon Bok Kim
Publikováno v:
Drug Metabolism and Pharmacokinetics. 31:107-116
The effect of rifampin on the in vivo metabolism of the antiretroviral drug efavirenz was evaluated in healthy volunteers. In a cross-over placebo control trial, healthy subjects (n = 20) were administered a single 600 mg oral dose of efavirenz after
Autor:
Michael J. Detke, Sharon Rosenzweig-Lipson, Janet B. W. Williams, Earl L. Giller, John M. Kane, Joan H.Q. Shen, Danielle Popp, Yonggang Zhao
Publikováno v:
Journal of Psychiatric Research. 53:14-22
Vabicaserin, a potent 5-HT2C receptor agonist, decreases nucleus accumbens extracellular dopamine levels in rats, without affecting striatal dopamine, indicating mesolimbic selectivity. This is the first study of efficacy, safety and tolerability of