Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joan H. Rotaru"'
Autor:
Joan H. Rotaru, Nilendu Gupta, Jeffrey A. Coderre, Rolf F. Barth, Einar K. Rofstad, Marta M. Nawrocky, Brent J. Albertson, Melvin L. Moeschberger, Amy K. Ferketich, John C. Grecula, Weilan Yang
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 58:267-277
Purpose Boron neutron capture therapy (BNCT) has been used clinically as a single modality treatment for high-grade gliomas and melanomas metastatic to the brain. The purpose of the present study was to determine whether its efficacy could be enhance
Autor:
Marta M. Nawrocky, Raymond T. Bartus, Joan H. Rotaru, Jeffrey A. Coderre, Amy K. Ferketich, Weilian Yang, Melvin L. Moeschberger, Rolf F. Barth, Einar K. Rofstad
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 52:858-868
Purpose : Multicentric cerebral metastases of melanoma represent an important clinical problem for which there currently is no satisfactory treatment. We previously developed a model for melanoma metastatic to the brain employing nude rats bearing in
Autor:
Joan H. Rotaru, Robert J. Lee, Masaru Sekido, Jennifer J. Sudimack, Dianne M. Adams, Rolf F. Barth, Junhua Yan, Supriya Shukla, Werner Tjarks
Publikováno v:
Pharmaceutical Research. 19:1502-1508
Purpose. This study was aimed at the in vitro evaluations of folate receptor (FR)-targeted liposomes as carriers for a lipophilic boron agent, K[nido-7-CH3(CH2)15-7,8-C2B9H11], in FR-overexpressing tumor cells for neutron capture therapy.
Autor:
Rolf F. Barth, Joseph H. Goodman, Raymond T. Bartus, Joan H. Rotaru, Jeffrey A. Coderre, Weilian Yang, Amy K. Ferketich, Melvin L. Moeschberger, Marta M. Nawrocky
Publikováno v:
Neurosurgery. 47:189-198
OBJECTIVE Cereport (Alkermes, Inc., Cambridge, MA), or, as it has been previously called, RMP-7 (receptor-mediated permeabilizer-7), is a bradykinin analog that has been shown to produce a transient, pharmacologically mediated opening of the blood-br
Autor:
Virginia M. Goettl, Jacqueline C. Bresnahan, Carl P. Boesel, Darrel D. Joel, Marie Hadjiconstantinou, David A. Wilkie, Joan H. Rotaru, Rolf F. Barth, Marta M. Nawrocky, Weilian Yang
Publikováno v:
Journal of Neuro-Oncology. 48:179-190
Sodium borocaptate (BSH) and boronophenylalanine (BPA) are two drugs that have been used clinically for boron neutron capture therapy (BNCT) of brain tumors. We previously have reported that hyperosmotic mannitol-induced disruption of the blood–bra
Autor:
Darrel D. Joel, Marta M. Nawrocky, Melvin L. Moeschberger, Joan H. Rotaru, Weilian Yang, Joseph H. Goodman, Rolf F. Barth
Publikováno v:
Journal of Neuro-Oncology. 33:59-70
Boronophenylalanine (BPA) has been used for boron neutron capture therapy (BNCT) of brain tumors in both experimental animals and humans. The purpose of the present study was to determine if the efficacy of BNCT could be enhanced by means of intracar
Autor:
Rolf F, Barth, Weilian, Yang, Dianne M, Adams, Joan H, Rotaru, Supriya, Shukla, Masaru, Sekido, Werner, Tjarks, Robert A, Fenstermaker, Michael, Ciesielski, Marta M, Nawrocky, Jeffrey A, Coderre
Publikováno v:
Cancer research. 62(11)
Success of boron neutron capture therapy (BNCT) is dependent on cellular and molecular targeting of sufficient amounts of boron-10 to sustain a lethal (10)B (n, alpha) (7)Li capture reaction. The purpose of the present study was to determine the effi
Autor:
Birte Otersen, James R. Lang, Zunyan Dai, Marta M. Nawrocky, Joan H. Rotaru, Rolf F. Barth, Weilian Yang, Michael A. Domet
Publikováno v:
Frontiers in Neutron Capture Therapy ISBN: 9781461354789
Apoptosis, or programmed cell death,1 is a process that can be initiated by a variety of external stimuli, including drugs2 and ionizing radiation,3 to activate a complex sequence of intracellular events that lead to death.4 Once initiated, both the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c135afd30e211a3cf55d0c5560200344
https://doi.org/10.1007/978-1-4615-1285-1_198
https://doi.org/10.1007/978-1-4615-1285-1_198
Autor:
Jianping Cai, Werner Tjarks, Joan H. Rotaru, Rolf F. Barth, Jin-Cong Zhuo, Albert H. Soloway, Weihua Ji, Dianne M. Adams
Publikováno v:
Frontiers in Neutron Capture Therapy ISBN: 9781461354789
The use of BNCT as a cancer treatment modality has been well documented.1,2 The boron-containing delivery agent should be non-toxic, selectively target tumor cells and ideally localize within the nucleus. Various boron-containing analogues of biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95b3213ab0052b6b06ec5d65a9a7b92
https://doi.org/10.1007/978-1-4615-1285-1_170
https://doi.org/10.1007/978-1-4615-1285-1_170
Autor:
Joan H. Rotaru, Weilian Yang, Darrel D. Joel, Rolf F. Barth, Maria Hadjiconstantinous, Marta M. Nawrocky, Jacqueline C. Bresnahan
Publikováno v:
Frontiers in Neutron Capture Therapy ISBN: 9781461354789
The blood-brain barrier (BBB), which is formed by tight junctions of endothelial cells lining cerebral blood vessels and capillaries, effectively limits the delivery of most water soluble chemotherapeutic agents to brain tumors and surrounding brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2216351bca45f5d1012c0cef5da1676f
https://doi.org/10.1007/978-1-4615-1285-1_202
https://doi.org/10.1007/978-1-4615-1285-1_202