Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joan G. Wilson"'
Autor:
Alexandra Badea, Wenlin Wu, Jordan Shuff, Michele Wang, Robert J. Anderson, Yi Qi, G. Allan Johnson, Joan G. Wilson, Serge Koudoro, Eleftherios Garyfallidis, Carol A. Colton, David B. Dunson
Publikováno v:
Frontiers in Neuroinformatics, Vol 13 (2019)
The major genetic risk for late onset Alzheimer’s disease has been associated with the presence of APOE4 alleles. However, the impact of different APOE alleles on the brain aging trajectory, and how they interact with the brain local environment in
Externí odkaz:
https://doaj.org/article/aa0c21819b164b7aa44d35d39519f959
Autor:
Carolyn Root, Chari D. Smith, Scott S. Sundseth, Heather M. Pink, Joan G. Wilson, Michael C. Lewis
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 8, Pp 1320-1330 (2002)
264W94 was designed to inhibit the ileal bile acid transporter (IBAT). Evaluated in vitro, 264W94 dose-dependently inhibited sodium-dependent uptake of 10 μM [3H]taurocholic acid (TC) by rat and monkey brush border membrane vesicles with IC50s of 0.
Externí odkaz:
https://doaj.org/article/3375d6adb368410b80d7a61d8ea04ce8
Autor:
Joan G. Wilson, M. Arthur Moseley, Carol A. Colton, W. Kirby Gottschalk, Kendra J. Adams, David S. Millington, J. Will Thompson
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32:1448-1458
Immune-based metabolic reprogramming of arginine utilization in the brain contributes to the neuronal pathology associated with Alzheimer's disease (AD). To enable our long-term goals of differentiation of AD mouse model genotypes, ages, and sexes ba
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31993 (2012)
Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein through the inhibition of glycogen-synthase kinase 3-beta (GSK3β). We recently developed a mouse model that progresses from amyloid pathology to tau
Externí odkaz:
https://doaj.org/article/338f4947c8dc4c3689e37d39e522c5bc
Autor:
Donna M Wilcock, Qun Zhao, Dave Morgan, Marcia N Gordon, Angela Everhart, Joan G Wilson, Jennifer E Lee, Carol A Colton
Publikováno v:
ASN Neuro, Vol 3 (2011)
While the presence of an inflammatory response in AD (Alzheimer's disease) is well known, the data on inflammation are conflicting, suggesting that inflammation either attenuates pathology, exacerbates it or has no effect. Our goal was to more fully
Externí odkaz:
https://doaj.org/article/254f598d7ff34b4db8c9c848010526b3
Autor:
Marilyn Jansen, Andrew N. Hoofnagle, Candice M. Brown, Jennifer E. Lee, Joan G. Wilson, Michael D. Gunn, Carol A. Colton, Matthew J. Kan, Michael P. Vitek, Angela Everhart
Publikováno v:
The Journal of Neuroscience. 35:5969-5982
The pathogenesis of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demonstrated a strong association between altered brain immune responses and disease progression, the mechanistic cause of neuronal dysfunc
Autor:
Jukka Puoliväli, Angela Everhart, Juho Oksman, Teemu Laitinen, Kimmo Lehtimäki, Nina Vartiainen, Joan G. Wilson, Carol A. Colton, Michael P. Vitek, Olli Jääskeläinen, Donna M. Wilcock, Taneli Heikkinen
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Supplemental digital content is available in the text.
Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensi
Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensi
Autor:
W. Wallace Harrington, Diane M. Ignar, William R. Oliver, Joan G. Wilson, Jane G Binz, David C. Lobe, Christy S. Britt, Michael C. Lewis, Naphtali Milliken
Publikováno v:
PPAR Research. 2007:1-13
Activation of peroxisome proliferator-activated receptor (PPAR)α,δ, andγsubtypes increases expression of genes involved in fatty acid transport and oxidation and alters adiposity in animal models of obesity and type-2 diabetes. PPARpan agonists wh
Autor:
Michael P. Vitek, Lisa A. Ridnour, Marilyn Jansen, Angela Everhart, David A. Wink, Michael D. Hoos, Joan G. Wilson, Carol A. Colton
Publikováno v:
Molecular Neurodegeneration
Background Mouse models are used in the study of human disease. Despite well-known homologies, the difference in immune response between mice and humans impacts the application of data derived from mice to human disease outcomes. Nitric oxide synthas
Autor:
Chari D. Smith, Carolyn Root, Joan G. Wilson, Scott S. Sundseth, Michael C. Lewis, Heather M. Pink
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 8, Pp 1320-1330 (2002)
264W94 was designed to inhibit the ileal bile acid transporter (IBAT). Evaluated in vitro, 264W94 dose-dependently inhibited sodium-dependent uptake of 10 micro M [(3)H]taurocholic acid (TC) by rat and monkey brush border membrane vesicles with IC(50