Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Autor: François Hoh, Julie Kniazeff, Juan Lorenzo Catena, Cyril Goudet, Jean-Philippe Pin, Xavier Gómez-Santacana, Anaëlle Dumazer, Jean-Louis Banères, Ludovic Berto, Fanny Malhaire, Amadeu Llebaria, Robert B. Quast, Alice E. Berizzi, Giuseppe Cannone, Kutti R. Vinothkumar, Chia-Ying Huang, Chady Nasrallah, Guillaume Lebon, Julie Briot, Joan Font-Ingles, Karine Rottier

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
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Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩

Summary Metabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors activated by the main excitatory neurotransmitter, L-glutamate. mGluR activation by agonists binding in the venus flytrap domain is regulated by positive (PAM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605603c382f708216045efdd1bc23c48
https://hal.archives-ouvertes.fr/hal-03340751/document

D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease

Autor: Irene, Sebastianutto, Elise, Goyet, Laura, Andreoli, Joan, Font-Ingles, David, Moreno-Delgado, Nathalie, Bouquier, Céline, Jahannault-Talignani, Enora, Moutin, Luisa, Di Menna, Natallia, Maslava, Jean-Philippe, Pin, Laurent, Fagni, Ferdinando, Nicoletti, Fabrice, Ango, M Angela, Cenci, Julie, Perroy

Publikováno v: J Clin Invest

Dopamine receptor D1 modulates glutamatergic transmission in cortico-basal ganglia circuits and represents a major target of L-DOPA therapy in Parkinson’s disease. Here we show that D1 and metabotropic glutamate type 5 (mGlu5) receptors can form pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::249340453eee375f8b8fb47f956905f4
https://pubmed.ncbi.nlm.nih.gov/32039920