RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB ActivationSummary

Autor: Jerry Wong, Ricard Garcia-Carbonell, Matija Zelic, Samuel B. Ho, Brigid S. Boland, Shih-Jing Yao, Shalin A. Desai, Soumita Das, Núria Planell, Philip A. Harris, Joan Font-Burgada, Koji Taniguchi, John Bertin, Azucena Salas, Manolis Pasparakis, Pete J. Gough, Michelle Kelliher, Michael Karin, Monica Guma

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 295-312 (2020)

Background and Aims: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill n

Externí odkaz: https://doaj.org/article/4bf9bd1fe4534fd6a45b7e148464a13a

MHC-I genotype drives early immune selection of oncogenic mutations

Autor: Rachel Marty, Nicola de Prisco, Hannah Carter, Joan Font-Burgada

Publikováno v: Molecular & Cellular Oncology, Vol 5, Iss 2 (2018)

MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immu

Externí odkaz: https://doaj.org/article/ce5fcd253dc34489acfe18c8c1832e02

Characterizing MHC-I Genotype Predictive Power for Oncogenic Mutation Probability in Cancer Patients

Autor: Lainie, Beauchemin, Michael, Slifker, David, Rossell, Joan, Font-Burgada

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2131

MHC class I proteins present intracellular peptides on the cell's surface, enabling the immune system to recognize tumor-specific neoantigens of early neoplastic cells and eliminate them before the tumor develops further. However, variability in pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2a8e4fd902d0508363f93edeff63141
https://pubmed.ncbi.nlm.nih.gov/32162254

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

Autor: P J Gough, Koji Taniguchi, Núria Planell, John Bertin, Soumita Das, Matija Zelic, Manolis Pasparakis, Philip A. Harris, Samuel B. Ho, Ricard Garcia-Carbonell, Shih Jing Yao, Joan Font-Burgada, Michelle A. Kelliher, Azucena Salas, Jerry Wong, Michael Karin, Monica Guma, Shalin A. Desai, Brigid S. Boland

Publikováno v: Cellular and molecular gastroenterology and hepatology, vol 9, iss 2
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 295-312 (2020)

Background and Aims: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d066f3e6066a30628cb304b6fb9eaca
https://escholarship.org/uc/item/19s668h3

Specific Labeling and Lineage Tracing of Periportal Hepatocytes Using Two-Step Genetic Recombination

Autor: Nicola, de Prisco, Eleanor, Stout, Joan, Font-Burgada

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1905

The liver is unmatched in regenerative capacity. However, when exhausted, the liver is predisposed to various diseases based on injury types and causal agents. Although hepatocytes have been proposed to be the main source of new hepatocytes during re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f48efd02c0d786ac058c0a1b3fd48fb0
https://pubmed.ncbi.nlm.nih.gov/30536090