Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joan E. Humphreys"'
Autor:
Susan L Ford, Gary D Bowers, Lindsey O. Webster, Elizabeth P Gould, Joseph W. Polli, Melinda J. Reese, Joan E. Humphreys
Publikováno v:
Xenobiotica. 46:445-456
1. Cabotegravir (CAB; GSK1265744) is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. 2. This work investigated if CAB was a substrate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee029c6cb38b7a6d4adef529a07b55e
https://doi.org/10.3109/00498254.2015.1081993
https://doi.org/10.3109/00498254.2015.1081993
Autor:
Paul M. Savina, Joseph W. Polli, Eri Kanaoka, Grant T. Generaux, James D. Clarke, Kelly A. Harmon, Helen Tracey, Melinda J. Reese, Joan E. Humphreys, Lindsey O. Webster
Publikováno v:
Drug Metabolism and Disposition. 41:353-361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993f8bf7610b57cb92f53b9a937dadea
https://doi.org/10.1124/dmd.112.048918
https://doi.org/10.1124/dmd.112.048918
Autor:
Wenli Tao, J. Sigafoos, Robert L. Dobbins, Anita Kapur, Stephen Castellino, David S. Wagner, Joan E. Humphreys, Joseph W. Polli, Melinda J. Reese, Elizabeth K. Hussey, Gary D Bowers, Amanda G. Culp, Robin L. O'Connor Semmes
Publikováno v:
Drug Metabolism and Disposition. 40:2090-2101
Remogliflozin etabonate is the ester prodrug of remogliflozin, a selective sodium-dependent glucose cotransporter-2 inhibitor. This work investigated the absorption, metabolism, and excretion of [(14)C]remogliflozin etabonate in humans, as well as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e117e38342441abf69a32eb67645b2a1
https://doi.org/10.1124/dmd.112.047258
https://doi.org/10.1124/dmd.112.047258
Autor:
Victoria E. Thiel-Demby, Nipa Shah, Lisa A St John Williams, Andrew Ayrton, Harma Ellens, Joseph W. Polli, Joan E. Humphreys
Publikováno v:
Molecular Pharmaceutics. 6:11-18
The Biopharmaceutics Classification System (BCS) is the scientific basis for classifying drugs based on their aqueous solubility and intestinal permeability that supports in vivo bioavailability and bioequivalence waivers for immediate-release solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086f0b41639d5aaf35ac5461f083c9cb
https://doi.org/10.1021/mp800122b
https://doi.org/10.1021/mp800122b
Autor:
Katie L Olson, Michael J O'Mara, Kevin M Koch, Joan E. Humphreys, Cosette J. Serabjit-Singh, Joseph W. Polli, Lisa A St. John-Williams, Stephen Castellino, Kelly A. Harmon
Publikováno v:
Drug Metabolism and Disposition. 36:695-701
Lapatinib [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, GW572016, Tykerb] is a tyrosine kinase inhibitor approved for use in combination with capecitabine to treat advanced or me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3e378526eba100e5da5be5c0254128
https://doi.org/10.1124/dmd.107.018374
https://doi.org/10.1124/dmd.107.018374
Autor:
Cosette J. Serabjit-Singh, Jarkko Rautio, Lindsey O. Webster, Jeevan R. Kunta, Joseph W. Polli, John P. Keogh, Anand Balakrishnan, Joan E. Humphreys
Publikováno v:
Drug Metabolism and Disposition. 34:786-792
Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-drug interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is anticipated that information regarding the potential interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b801a72997d3eeb4af00ceb47dd0d4
https://doi.org/10.1124/dmd.105.008615
https://doi.org/10.1124/dmd.105.008615
Autor:
Cosette J. Serabjit-Singh, Victoria E. Thiel-Demby, Joseph W. Polli, Timothy K. Tippin, Joan E. Humphreys
Publikováno v:
Journal of Pharmaceutical Sciences. 93:2567-2572
The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b113a886c68628f3b4359453bf477778
https://doi.org/10.1002/jps.20166
https://doi.org/10.1002/jps.20166
Autor:
Robert J. Barnaby, Cosette J. Serabjit-Singh, Luigina Bertolotti, Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Angela L. Mote, Giovanni Vitulli, Kevin D. Read, Lindsey O. Webster, Kelly H. Jordan
Publikováno v:
Drug Metabolism and Disposition. 32:722-726
This article is available online at http://dmd.aspetjournals.org ABSTRACT: GV196771 (E-4,6-dichloro-3-(2-oxo-1-phenyl-pyrrolidin-3-glyden- emethyl)-1H-indole-2 carboxylic acid) is a potent antagonist of the modulatory glycine site of the N-methyl-D-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c45942d2fe954230dcbcd882f0391e
https://doi.org/10.1124/dmd.32.7.722
https://doi.org/10.1124/dmd.32.7.722
Autor:
Jo A. Salisbury, Joan E. Humphreys, Cosette J. Serabjit-Singh, Todd M. Baughman, Timothy K. Tippin, Kelly H. Jordan, Joseph W. Polli, Angela L. Mote
Publikováno v:
Journal of Pharmaceutical Sciences. 92:2082-2089
Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5448bc4ec1f72563033849add475017
https://doi.org/10.1002/jps.10453
https://doi.org/10.1002/jps.10453
Autor:
Lindsey O. Webster, Larry J. Shampine, Kelly M. Mahar Doan, Cosette J. Serabjit-Singh, Joan E. Humphreys, Joseph W. Polli, Stephen A. Wring, Kimberly K. Adkison
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:1029-1037
Membrane permeability and P-glycoprotein (Pgp) can be limiting factors for blood-brain barrier penetration. The objectives of this study were to determine whether there are differences in the in vitro permeability, Pgp substrate profiles, and physico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04938d6ea46ed6b20a21653aed29fb5
https://doi.org/10.1124/jpet.102.039255
https://doi.org/10.1124/jpet.102.039255