Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joan E. Brown"'
Autor:
John A. Hey, Mwangi W. Mutahi, Susan She, Robert G. Aslanian, Robert E. West, Michael J. Green, Maurice del Prado, Joan E. Brown, N.-Y. Shih
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2263-2268
A series of amidine substituted phenyl-, benzyl-, and phenethylimidazoles based on the known H3 agonist SK&F 91606 (4) has been synthesized and tested as ligands for the histamine H3 receptor. Insertion of a phenyl ring between the imidazole ring and
Autor:
A.K. Ganguly, Taveras Arthur G, Mark E. Snow, Doll Ronald J, J. del Rosario, Larry Heimark, Birendra N. Pramanik, Bancha Vibulbhan, Yu-Sen Wang, Joan E. Brown, V. Girijavallabhan, Stephen D. Liberles, D. Cesarz, Yi-Tsung Liu, Paul Kirschmeier, Eric C. Huang, Stacy W. Remiszewski, Anthony Tsarbopoulos, Linda James
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:817-820
MS based methodology employing electrospray ionization (ESI) is described for the detection of ternary complexes in which SCH 54292 or SCH 54341 and GDP are noncovalently bound to oncogenic ras protein. The observed molecular weights of 19,816 and 19
Autor:
A.K. Ganguly, Taveras Arthur G, Robert M. Aust, Doll Ronald J, Mark E. Snow, W. Sisson, Birendra N. Pramanik, D. M. Delisle, Charles R. Kissinger, Shella A. Fuhrman, Mary M. Senior, Bancha Vibulbhan, Yu-Sen Wang, C.A. Evans, Paul Kirschmeier, Stacy W. Remiszewski, B.B. Bauer, Louise M. Perkins, V. Girijavallabhan, D. Cesarz, Robert A. Love, Joseph J. Catino, Eric C. Huang, C. Nash, Joan E. Brown, Larry Heimark, Donna Carr, Linda James, E. Villafranca, Anthony Tsarbopoulos, Edward L. Brown, S.E. Webber, Thomas F. Hendrickson, Stephen D. Liberles, J. del Rosario
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:125-133
The nucleotide exchange process is one of the key activation steps regulating the ras protein. This report describes the development of potent, non-nucleotide, small organic inhibitors of the ras nucleotide exchange process. These inhibitors bind to
Publikováno v:
Trends in Pharmacological Sciences. 17:389-393
Alzheimer’s disease is a progressive onal and synaptic loss. Approxineurodegenerative disease cbdracmately 10% of Alzheimer’s disease terized by memory loss and personcases are characterized by early ality changes. Morphologisally, the onset (age
Autor:
Guowei Zhou, Joan E. Brown, Melissa A.B. Tice, Nicholas J. Murgolo, Robert D. McQuade, Lisa A. Taylor, Joseph A. Kozlowski, Frank Hollinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:785-788
An analog (SCH55112) of pirenzepine was prepared in which the N4 piperazyl nitrogen was replaced with carbon. This structrual change abolished the 55-fold m1/m2 selectivity of pirenzepine due to specific loss of m1 affinity. Mutagenesis mapping and m
Autor:
M. Wa Mutahi, Susan She, N.-Y. Shih, Robert E. West, Michael J. Green, M. del Prado, John A. Hey, Robert G. Aslanian, Joan E. Brown
Publikováno v:
ChemInform. 30
Publikováno v:
Military medicine. 170(3)
Clinical practice guidelines (CPGs) are common, but it is not clear whether they improve care.Quality indicators for processes and outcomes of care were obtained from a computerized system-wide database by patient administration and utilization manag
Autor:
Lisa A. Taylor, Melissa A.B. Tice, Ruth A. Duffy, Joseph A. Kozlowski, Robert D. McQuade, Jean E. Lachowicz, Vilma Ruperto, Derek B. Lowe, Catherine D. Strader, Nicholas J. Murgolo, John W. Clader, Henry Guzik, Joel G. Berger, Joan E. Brown
Publikováno v:
Life sciences. 64(6-7)
As a decrease in cholinergic neurons has been observed in Alzheimer's Disease (AD), therapeutic approaches to AD include inhibition of acetylcholinesterase to increase acetylcholine levels. Evidence suggests that acetylcholine release in the CNS is m
Autor:
Paul Kirschmeier, Thomas F. Hendrickson, Remiszewski Stacy W, Wess A. Sisson, Doll Ronald J, Birendra N. Pramanik, Ashit K. Ganguly, David Cesarz, and Anthony Tsarbopoulos, Steve E. Webber, Eric C. Huang, Yu-Sen Wang, Joan E. Brown, Viyyoor M. Girijavallabhan, Robert A. Love, Bancha Vibulbhan, Taveras Arthur G, Robert M. Aust, Mark E. Snow, J. del Rosario, Edward L. Brown, Shella A. Fuhrman, Larry Heimark, and J. Ernest Villafranca, Charles R. Kissinger, D. M. Delisle
Publikováno v:
Biochemistry. 37(45)
Mutated, tumorigenic Ras is present in a variety of human tumors. Compounds that inhibit tumorigenic Ras function may be useful in the treatment of Ras-related tumors. The interaction of a novel GDP exchange inhibitor (SCH-54292) with the Ras-GDP pro
Autor:
Nicholas J. Murgolo, M. Motasim Billah, Scott Greenfeder, Joan E. Brown, John C. Anthes, Boonlert Cheewatrakoolpong, Robert W. Egan
Publikováno v:
Bioorganicmedicinal chemistry. 6(2)
The neuropeptide substance P binds to the G protein-coupled neurokinin-1 (NK-1) receptor and elicits cellular responses thought to be involved in pain, neurogenic inflammation, vasodilatation, and plasma exudation. Several small molecule nonpeptide a