Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies

Autor: Rashi Gupta, Emma Vanlieshout, Kieran Manion, Dennisse Bonilla, Michael Kim, Carolina Muñoz-Grajales, Carol Nassar, Sindhu R. Johnson, Linda T. Hiraki, Zareen Ahmad, Zahi Touma, Arthur Bookman, Joan E. Wither

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Systemic Autoimmune Rheumatic Diseases (SARDs) are characterized by the production of anti-nuclear antibodies (ANAs). ANAs are also seen in healthy individuals and can be detected years before disease onset in SARD. Both the immunological changes tha

Externí odkaz: https://doaj.org/article/fa97e07671a445f5b15aade16e9bbdd2

1501 Genetics of age at systemic lupus erythematosus diagnosis

Autor: Janet E Pope, Daniel J Wallace, Murray B Urowitz, Dafna D Gladman, Diane L Kamen, Christine A Peschken, Zahi Touma, Earl D Silverman, Mariko Ishimori, Andrew D Paterson, Deborah M Levy, Sylvia Kamphuis, Linda T Hiraki, Marisa S Klein-Gitelman, Jingjing Cao, Declan Webber, Daniela Dominguez, Andrea M Knight, Joan E Wither, Raffaella Carlomagno, Fangming Liao, Caroline Jefferies, Chia-Chi J Lee, Karen B Onel

Publikováno v: Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/05f5dfdd2ee04191a2084ef4d6f2b844

Assessing the Utility of the Montreal Cognitive Assessment in Screening for Cognitive Impairment in Patients With Systemic Lupus Erythematosus

Autor: Oshrat E. Tayer‐Shifman, Kimberley Yuen, Robin Green, Mahta Kakvan, Patricia Katz, Kathleen S. Bingham, Juan Pablo Diaz‐Martinez, Lesley Ruttan, Joan E. Wither, Maria Carmela Tartaglia, Jiandong Su, Dennisse Bonilla, May Y. Choi, Simone Appenzeller, Michelle Barraclough, Dorcas E. Beaton, Zahi Touma

Publikováno v: Arthritis Care & Research. 75:569-577

Screening for cognitive impairment (CI) in systemic lupus erythematosus (SLE) relies on the American College of Rheumatology (ACR) neuropsychological battery (NB). By studying the concurrent criterion validity, our goal was to assess the Montreal Cog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dae1cd0e61f7c4446cec3a76d0953ef
https://doi.org/10.1002/acr.24971

Transancestral mapping and genetic load in systemic lupus erythematosus

Autor: Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp

Externí odkaz: https://doaj.org/article/a68227bc3ba0457486591e4743061bf9

Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms.

Autor: Joan E Wither, Stephenie D Prokopec, Babak Noamani, Nan-Hua Chang, Dennisse Bonilla, Zahi Touma, Carmen Avila-Casado, Heather N Reich, James Scholey, Paul R Fortin, Paul C Boutros, Carolina Landolt-Marticorena

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196117 (2018)

Both a lack of biomarkers and relatively ineffective treatments constitute impediments to management of lupus nephritis (LN). Here we used gene expression microarrays to contrast the transcriptomic profiles of active SLE patients with and without LN

Externí odkaz: https://doaj.org/article/2ec9b1e45cac413fa0380304caca501b