Výsledky vyhledávání - "Joan C. Tupper"

Akademický článek

Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis.

Autor: Akiko Iwata, R Angelo de Claro, Vicki L Morgan-Stevenson, Joan C Tupper, Barbara R Schwartz, Li Liu, Xiaodong Zhu, Katherine C Jordan, Robert K Winn, John M Harlan

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e14729 (2011)

Severe sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic manipulation of death and survival pathways has been shown to modulate organ

Externí odkaz: https://doaj.org/article/3763326c217a4beda13f907baf8de85f

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Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

Autor: Michael W. Schwartz, Matilda Pham, Douglas D. Bannerman, Joshua P. Thaler, Thomas R. Hawn, Ian Luttrell, Elaine W. Raines, Joan C. Tupper, Francis Kim

Publikováno v: Circulation Research. 100:1589-1596

Vascular dysfunction is a major complication of metabolic disorders such as diabetes and obesity. The current studies were undertaken to determine whether inflammatory responses are activated in the vasculature of mice with diet-induced obesity, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfd76386d67c544aa3f4073132f7bd5
https://doi.org/10.1161/circresaha.106.142851

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Bcl-2 Overexpression Leads to Increases in Suppressor of Cytokine Signaling-3 Expression in B Cells and De novo Follicular Lymphoma

Autor: Gary J. Vanasse, Robert K. Winn, Sofya Rodov, Arthur W. Zieske, John T. Li, Joan C. Tupper, Jingjing Tang, Elaine W. Raines, Mette A. Peters, Ka Yee Yeung, John M. Harlan

Publikováno v: Molecular Cancer Research. 2:620-631

The t(14;18)(q32;q21), resulting in deregulated expression of B-cell-leukemia/lymphoma-2 (Bcl-2), represents the genetic hallmark in human follicular lymphomas. Substantial evidence supports the hypothesis that the t(14;18) and Bcl-2 overexpression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d73742113ed828ca2e9222f866bf3816
https://doi.org/10.1158/1541-7786.620.2.11

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Over-Expression of Bcl-2 Provides Protection in Septic Mice by a trans Effect

Autor: Annie Minard, John M. Harlan, Michael Tasch, Vicki Morgan Stevenson, Robert K. Winn, Eric Lagasse, Irving L. Weissman, Joan C. Tupper, Akiko Iwata

Publikováno v: The Journal of Immunology. 171:3136-3141

Transgenic mice that over-express B cell leukemia/lymphomas (Bcl)-2 in myeloid cells under control of the human MRP8 promoter (hMRP8-Bcl-2) or in T lymphocytes under the Eμ promoter (Eμ-Bcl-2) were compared with C57BL/6 control mice following cecal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5f164eb5cfe9d2c17360a2c83362ee
https://doi.org/10.4049/jimmunol.171.6.3136

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Shiga toxin induces decreased expression of the anti-apoptotic protein Mcl-1 concomitant with the onset of endothelial apoptosis

Autor: Kristine T. Eiting, John M. Harlan, Ryan D. Erwert, Robert K. Winn, Joan C. Tupper, Douglas D. Bannerman

Publikováno v: Microbial Pathogenesis. 35:87-93

Shiga toxin (Stx) has been implicated in the pathogenesis of several human and animal disease states. A key host target of Stx is the endothelial cell. Stx induces endothelial cell apoptosis through a mechanism that remains unknown. In the present re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a76850b7e1942307483aff2ba7199f7
https://doi.org/10.1016/s0882-4010(03)00100-1

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Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells

Autor: Robert K. Winn, Joan C. Tupper, John M. Harlan, Douglas D. Bannerman, Christopher J. Rhodes, Xianwu Li

Publikováno v: Infection and Immunity. 71:4414-4420

Many of the proinflammatory effects of gram-negative bacteria are elicited by the interaction of bacterial lipopolysaccharide (LPS) with Toll-like receptor 4 (TLR4) expressed on host cells. TLR4 signaling leads to activation of NF-kappa B and transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c288f40ec4712e025ef122f05670055
https://doi.org/10.1128/iai.71.8.4414-4420.2003

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A Constitutive Cytoprotective Pathway Protects Endothelial Cells from Lipopolysaccharide-induced Apoptosis

Autor: Robert K. Winn, William Ricketts, C. Frank Bennett, Joan C. Tupper, John M. Harlan, Douglas D. Bannerman

Publikováno v: Journal of Biological Chemistry. 276:14924-14932

Lipopolysaccharide (LPS) has been implicated as the bacterial component responsible for much of the endothelial cell injury/dysfunction associated with Gram-negative bacterial infections. Protein synthesis inhibition is required to sensitize the endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb69b13052decfcb96c0502be224d19
https://doi.org/10.1074/jbc.m100819200

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NF-κB Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-α but Not to Interleukin-1β or Lipopolysaccharide

Autor: Thomas Eunson, Mark A. Kay, Katsuhiro Zen, Xianwu Li, Christopher B. Wilson, Aly Karsan, Esther Yee, Joan C. Tupper, April Stempien-Otero, John M. Harlan, Robert K. Winn

Publikováno v: Journal of Biological Chemistry. 274:28808-28815

In the presence of a protein synthesis inhibitor, cycloheximide, tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL-1beta), or lipopolysaccharide (LPS) induces human umbilical vein endothelial cells (HUVECs) to undergo apoptosis, suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec9e05b5538b509661e296c8bfc37e2
https://doi.org/10.1074/jbc.274.40.28808

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Shear Stress-mediated Extracellular Signal-regulated Kinase Activation Is Regulated by Sodium in Endothelial Cells

Autor: Oren Traub, Mari Ishida, Joan C. Tupper, Bradford C. Berk, Takafumi Ishida

Publikováno v: Journal of Biological Chemistry. 274:20144-20150

Fluid shear stress is an important regulator of endothelial cell (EC) function. To determine whether mechanosensitive ion channels participate in the EC response to shear stress, we characterized the role of ion transport in shear stress-mediated ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3eff19893315b746088f6ad95e6285ea
https://doi.org/10.1074/jbc.274.29.20144

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FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling

Autor: Priya Handa, Joan C. Tupper, Katherine C Jordan, John M. Harlan

Publikováno v: Cell Communication and Signaling, Vol 9, Iss 1, p 16 (2011)
Cell Communication and Signaling : CCS

Background Cytoplasmic viral double-stranded RNA (dsRNA) is detected by a class of ubiquitous cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation antigen-5 (MDA5), which initiate a signaling cascade via thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8881ebb8c5efc6b7bffc7cd9921d5d
http://www.biosignaling.com/content/9/1/16

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