Regulation of human class I alcohol dehydrogenases by bile acids

Autor: Cédric Langhi, Elena Pedraz-Cuesta, Diego Haro, Pedro F. Marrero, Joan C. Rodríguez

Publikováno v: Journal of Lipid Research, Vol 54, Iss 9, Pp 2475-2484 (2013)

Class I alcohol dehydrogenases (ADH1s) are the rate-limiting enzymes for ethanol and vitamin A (retinol) metabolism in the liver. Because previous studies have shown that human ADH1 enzymes may participate in bile acid metabolism, we investigated whe

Externí odkaz: https://doaj.org/article/a0ada3cff88b43258fae9bebe97cacb3

Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha

Autor: Xavier Prieur, Joan C. Rodríguez, Philippe Lesnik, C. Doucet, M. John Chapman, Thierry Huby, Martine Moreau

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791:764-771

Mice have been used widely to define the mechanism of action of fibric acid derivatives. The fibrates are pharmacological agonists of the peroxisome proliferator-activated receptor α (PPARα), whose activation in human subjects promotes potent reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24d0f6fb05bb89cb9956a4a5804455ca
https://doi.org/10.1016/j.bbalip.2009.03.015

Regulation of N-Myc downstream regulated gene 2 by bile acids

Autor: Pedro F. Marrero, Joan C. Rodríguez, Diego Haro, Cédric Langhi, Elena Pedraz-Cuesta, Yolanda Donate

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a38b54037019209c839bffa9e1c8c9e
http://hdl.handle.net/2445/108593

Apolipoprotein AV: Gene expression, physiological role in lipid metabolism and clinical relevance

Autor: Joan C Rodríguez, Xavier Prieur, Philippe Couvert, Thierry Huby, M. John Chapman

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

The apolipoprotein APOA5 gene, a member of the gene cluster on chromosome 11q23 that includes APOA1, APOC3 and APOA4, has gained considerable interest as it encodes ApoAV, a key determinant of circulating levels of potentially atherogenic triglycerid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1f36c702ee73f3faf71c10fb7a07fe
http://hdl.handle.net/2445/183220

Thyroid hormone regulates the hypotriglyceridemic gene APOA5

Autor: Joan C. Rodríguez, Frank G. Schaap, Thierry Huby, Hervé Coste, M. John Chapman, Xavier Prieur

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Journal of biological chemistry, 280(30), 27533-27543. American Society for Biochemistry and Molecular Biology Inc.
Recercat. Dipósit de la Recerca de Catalunya
instname

The apolipoprotein AV gene (APOA5) is a key determinant of plasma triglyceride levels, a major risk factor for coronary artery disease and a biomarker for the metabolic syndrome. Since thyroid hormones influence very low density lipoprotein triglycer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10532f64450430ef323423047e6efb54
https://pubmed.ncbi.nlm.nih.gov/15941710