Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Joan C. Krepinsky"'
Autor:
Salma Abrahim, Alexandra P. Steele, Jennifer Voth, Joan C. Krepinsky, Matthew B. Lanktree, Thomas J. Hawke
Publikováno v:
Physiological Reports, Vol 12, Iss 15, Pp n/a-n/a (2024)
Abstract Chronic kidney disease (CKD) causes skeletal muscle wasting, resulting in reduced function and inability to live independently. This systematic review critically appraised the scientific literature regarding the effects of full‐body resist
Externí odkaz:
https://doaj.org/article/d7ec022f35254a18ab19e6339a989e79
Autor:
Jackie Trink, Ifeanyi Kennedy Nmecha, Dan Zhang, Melissa MacDonald, Bo Gao, Joan C. Krepinsky
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Diabetic kidney disease (DKD) is characterized by a progressive increase in albuminuria and typical pathologic features. Recent studies have shown that sex is an important factor to consider in the pathogenesis of DKD. Presently, the hallmar
Externí odkaz:
https://doaj.org/article/b21b26cb5f9240769ad0c2287e6d091f
Autor:
Asfia Soomro, Mohammad Khajehei, Renzhong Li, Kian O’Neil, Dan Zhang, Bo Gao, Melissa MacDonald, Masao Kakoki, Joan C. Krepinsky
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-22 (2023)
Abstract Background TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 profibrotic effect
Externí odkaz:
https://doaj.org/article/43923531da1b4e53aa88ea1a7a9900dd
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Diabetic kidney disease (DKD) is the leading cause of kidney failure in North America, characterized by glomerular accumulation of extracellular matrix (ECM) proteins. High glucose (HG) induction of glomerular mesangial cell (MC) profib
Externí odkaz:
https://doaj.org/article/7ee73d3682f046c392fd02c6dd0948a9
Autor:
Neel Mehta, Renzhong Li, Dan Zhang, Asfia Soomro, Juehua He, Ivan Zhang, Melissa MacDonald, Bo Gao, Joan C. Krepinsky
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Caveolin-1 (cav-1), an integral protein of the membrane microdomains caveolae, is required for synthesis of matrix proteins by glomerular mesangial cells (MC). Previously, we demonstrated that the antifibrotic protein follistatin (FST) is tr
Externí odkaz:
https://doaj.org/article/f0f843741c9940e68532df848db393bc
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2247 (2022)
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. Characterized by overproduction and accumulation of extracellular matrix (ECM) proteins, glomerular sclerosis is its earliest manifestation. High glucose (HG) plays a cen
Externí odkaz:
https://doaj.org/article/0aad5278e68e4392a5815b2be2161b9c
Autor:
Khrystyna Platko, Paul F. Lebeau, Jae Hyun Byun, Samantha V. Poon, Emily A. Day, Melissa E. MacDonald, Nicholas Holzapfel, Aurora Mejia-Benitez, Kenneth N. Maclean, Joan C. Krepinsky, Richard C. Austin
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp 62-74 (2019)
Objective: Growth differentiation factors (GDFs) and bone-morphogenic proteins (BMPs) are members of the transforming growth factor β (TGFβ) superfamily and are known to play a central role in the growth and differentiation of developing tissues. A
Externí odkaz:
https://doaj.org/article/9a0aa889f2324bde96265d42a39b9a03
Autor:
Neel Mehta, Dan Zhang, Renzhong Li, Tony Wang, Agata Gava, Pavithra Parthasarathy, Bo Gao, Joan C. Krepinsky
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is involved in regulating
Externí odkaz:
https://doaj.org/article/3ed36ca02db1467e9dd977cbfd6440b7
Autor:
Jackie Trink, Renzhong Li, Yaseelan Palarasah, Stéphan Troyanov, Thomas E. Andersen, Johannes J. Sidelmann, Mark D. Inman, Salvatore V. Pizzo, Bo Gao, Joan C. Krepinsky
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1112 (2021)
Diabetic kidney disease (DKD) is caused by the overproduction of extracellular matrix proteins (ECM) by glomerular mesangial cells (MCs). We previously showed that high glucose (HG) induces cell surface translocation of GRP78 (csGRP78), mediating PI3
Externí odkaz:
https://doaj.org/article/a4a52abce55648158b7ad8d3e885382e
Autor:
Asfia Soomro, Jackie Trink, Kian O’Neil, Renzhong Li, Safaa Naiel, Bo Gao, Kjetil Ask, Joan C. Krepinsky
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2839 (2021)
Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely through mediating the profibrotic response. While RhoA activation is not f
Externí odkaz:
https://doaj.org/article/7fa078df92474d5aa8ec31cadb5387f6