Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joan Brozick"'
Autor:
Tejas S Tirodkar, Raluca A Budiu, Esther Elishaev, Lixin Zhang, Jyothi T Mony, Joan Brozick, Robert P Edwards, Anda M Vlad
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102409 (2014)
Activating mutations of Kras oncogene and deletions of Pten tumor suppressor gene play important roles in cancers of the female genital tract. We developed here new preclinical models for gynecologic cancers, using conditional (Cre-loxP) mice with fl
Externí odkaz:
https://doaj.org/article/3e8480a1a65e4d3a907f7134a630a2b9
Autor:
Shannon Grabosch, Eun Kim, Andrea Gambotto, Tianzhou Ma, Lixin Zhang, Robert P. Edwards, Anda M. Vlad, Yusi Fang, Esther Elishaev, Joan Brozick, George C. Tseng, Mirna Bulatović, Feitianzhi Zeng, Malcolm S. Ross
Publikováno v:
Oncogene
The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive surgical debulking. New therapeutic approaches using immunotherapy via immune checkpoint blockade, which have demonstrated clinical efficacy in other tumor types,
Autor:
Ashley Stuckey, Heather A. Lankes, Robert P. Edwards, Wiam Bshara, Mary Strange, Michael J. Birrer, Joan Brozick, Joan L. Walker, Amit A. Lugade, Kathleen N. Moore, Kunle Odunsi, George C. Tseng, Angela Omilian, Anda M. Vlad, Tianzhou Ma, Shannon Grabosch
Publikováno v:
Gynecologic Oncology. 146:137-145
Objectives Ovarian cancer leads to abdominal carcinomatosis and late stage (III/IV) diagnosis in 75% of patients. Three randomized phase III trials have demonstrated that intraperitoneal (IP) chemotherapy improves outcomes in epithelial ovarian cance
Autor:
Tianzhou Ma, Lixin Zhang, Raluca Budiu, Anda M. Vlad, Joan Brozick, Kathlene Babalola, George C. Tseng
Publikováno v:
Oncogene
Mucin1 (MUC1) is an epithelial glycoprotein overexpressed in ovarian cancer and actively involved in tumor cell migration and metastasis. Using novel in vitro and in vivo MUC1-expressing conditional (Cre-loxP) ovarian tumor models, we focus here on M
Autor:
Joan Brozick, Anda M. Vlad, Pawel Kalinski, MinJae Lee, Esther Elishaev, Raluca Budiu, Robert P. Edwards
Publikováno v:
Oncogene. 32:3664-3675
Epithelial ovarian cancer is an aggressive malignancy, with a low 5-year median survival. Continued improvement on the development of more effective therapies depends in part on the availability of adequate preclinical models for in vivo testing of t
Autor:
Malcolm S. Ross, Tianzhou Ma, Robert P. Edwards, Shannon Grabosch, Esther Elishaev, Lixin Zhang, George C. Tseng, Mirna Bulatović, Anda M. Vlad, Feitianzhi Zeng, Joan Brozick
Publikováno v:
Clinical Cancer Research. 24:B29-B29
Objective: Front-line therapy in ovarian cancer combines platinum/taxane chemotherapy and surgery. We studied here the role of cisplatin on PDL1 biology in vitro and in vivo in new ovarian tumor models. We also explored the in vivo efficacy of PDL1 b
Autor:
Tianzhou Ma, Anda M. Vlad, Shannon Grabosch, Lixin Zhang, George C. Tseng, E. Guido, Robert P. Edwards, Joan Brozick, Feitianzhi Zeng
Publikováno v:
Gynecologic Oncology. 145:86
Autor:
George C. Tseng, Esther Elishaev, Lixin Zhang, Tejas Tirodkar, Xin Huang, Shannon Grabosch, Joan Brozick, Anda M. Vlad, Jyothi Thyagabhavan Mony, Tianzhou Ma, Robert P. Edwards
Publikováno v:
Cancer immunology, immunotherapy : CII. 64(9)
Monoclonal antibodies that block inhibitory immune checkpoint molecules and enhance anti-tumor responses show clinical promise in advanced solid tumors. Most of the preliminary evidence on therapeutic efficacy of immune checkpoint blockers comes from
Autor:
Jyothi Thyagabhavan Mony, Raluca Budiu, Tejas Tirodkar, Esther Elishaev, Robert P. Edwards, Joan Brozick, Lixin Zhang, Anda M. Vlad
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e102409 (2014)
PLoS ONE, Vol 9, Iss 7, p e102409 (2014)
Activating mutations of Kras oncogene and deletions of Pten tumor suppressor gene play important roles in cancers of the female genital tract. We developed here new preclinical models for gynecologic cancers, using conditional (Cre-loxP) mice with fl
Autor:
Lixin Zhang, Robert P. Edwards, Shannon Grabosch, Tianzhou Ma, Joan Brozick, Feitianzhi Zeng, George C. Tseng, Anda M. Vlad
Publikováno v:
Gynecologic Oncology. 141:86