Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joan B. Mannick"'
Autor:
Joan B Mannick, MD, Grace Teo, PhD, Patti Bernardo, PhD, Dean Quinn, MD, Kerry Russell, MD, Lloyd Klickstein, MD, William Marshall, MD, Sarb Shergill, PhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 2, Iss 5, Pp e250-e262 (2021)
Summary: Background: The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity that declines with age. In a previous phase 2a trial, RTB101 (previously
Externí odkaz:
https://doaj.org/article/f5480cc748d0443e8c74609dfce05fc3
Autor:
Lynne S Cox, Ilaria Bellantuono, Janet M Lord, Elizabeth Sapey, Joan B Mannick, Linda Partridge, Adam L Gordon, Claire J Steves, Miles D Witham
Publikováno v:
The Lancet. Healthy Longevity, Vol 1, Iss 2, Pp e55-e57 (2020)
Externí odkaz:
https://doaj.org/article/12cf3577c5254e7aa775daaaf76e4cc6
Autor:
Joan B. Mannick, Dudley W. Lamming
Publikováno v:
Nature Aging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90544b02b316f8ec0fe68cb84a1ba683
https://doi.org/10.1038/s43587-023-00416-y
https://doi.org/10.1038/s43587-023-00416-y
Autor:
Morgan E. Levine, Judith Campisi, Mitzi M. Gonzales, James L. Kirkland, Nir Barzilai, George A. Kuchel, Ana Maria Cuervo, Laura J. Niedernhofer, Luigi Ferrucci, Daniel E. L. Promislow, Loren M. DeVito, Joan B. Mannick, Pinchas Cohen, Jamie N. Justice, Sofiya Milman
Publikováno v:
Ann N Y Acad Sci
For many years, it was believed that the aging process was inevitable and that age-related diseases could not be prevented or reversed. The geroscience hypothesis, however, posits that aging is, in fact, malleable and, by targeting the hallmarks of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca34f173676ce523c3746de1c94b2d4a
https://doi.org/10.1111/nyas.14681
https://doi.org/10.1111/nyas.14681
Autor:
Paul D. Robbins, Sundeep Khosla, Douglas P. Kiel, Matthew C. Sorenson, Joan B. Mannick, Elizabeth J. Atkinson, Tamara Tchkonia, Raymond Yung, Stephen B. Kritchevsky, Nicolas Musi, Ravinder J. Singh, Erin O. Wissler-Gerdes, Teresa C McCarthy, George A. Kuchel, Michael A. Puskarich, James L. Kirkland, Larissa G.P. Langhi Prata, Nathan K. LeBrasseur, Laura J. Niedernhofer, Jeremy D. Walston, Stacey A. Rizza, Lewis A. Lipsitz, Robert J. Pignolo, Brandon P. Verdoorn, Tamara K. Evans, Yi Zhu, Gregory J. Hanson
Publikováno v:
Journal of the American Geriatrics Society
The burden of senescent cells (SnCs), which do not divide but are metabolically active and resistant to death by apoptosis, is increased in older adults and those with chronic diseases. These individuals are also at the greatest risk for morbidity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571769ce0f4c31e19f8ba16f0472a367
http://europepmc.org/articles/PMC8447437
http://europepmc.org/articles/PMC8447437
Autor:
Ilaria Bellantuono, Linda Partridge, Lynne S. Cox, Miles D. Witham, Elizabeth Sapey, Adam L. Gordon, Joan B Mannick, Janet M. Lord, Claire J. Steves
Publikováno v:
The Lancet. Healthy Longevity, Vol 1, Iss 2, Pp e55-e57 (2020)
The Lancet. Healthy Longevity
The Lancet Healthy Longevity
Lancet Healthy Longev
The Lancet. Healthy Longevity
The Lancet Healthy Longevity
Lancet Healthy Longev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc63eb08a24cc99c0471211157d4e62a
http://www.sciencedirect.com/science/article/pii/S2666756820300118
http://www.sciencedirect.com/science/article/pii/S2666756820300118
Autor:
Saul A. Villeda, Jan M. van Deursen, Joan B Mannick, Rafael de Cabo, Mary Armanios, Linda Partridge
Publikováno v:
Nat Med
Nature Medicine, 21, 12, pp. 1395-9
Nature Medicine, 21, 1395-9
Nature Medicine, 21, 12, pp. 1395-9
Nature Medicine, 21, 1395-9
Item does not contain fulltext Aging is a risk factor for several of the world's most prevalent diseases, including neurodegenerative disorders, cancer, cardiovascular disease and metabolic disease. Although our understanding of the molecular pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d36c453fa52d251c617eff52f73e74
https://europepmc.org/articles/PMC8785908/
https://europepmc.org/articles/PMC8785908/
Publikováno v:
Journal of Biological Chemistry. 278:18265-18270
Cytochrome c released from mitochondria into the cytoplasm plays a critical role in many forms of apoptosis by stimulating apoptosome formation and subsequent caspase activation. However, the mechanisms regulating cytochrome c apoptotic activity are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ee29c8fb3ec993851c15c5b4b1a5d
https://doi.org/10.1074/jbc.m212459200
https://doi.org/10.1074/jbc.m212459200
Autor:
Marten Szibor, Pedram Ghafourifar, Joan B. Mannick, Christopher M. Schonhoff, Benjamin Gaston, Natalia Papeta, Kezhong Fang
Publikováno v:
The Journal of Cell Biology
Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways. In resting cells, a subset of caspase-3 zymogens is S-nitrosylated at the active site cysteine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87265a9811434ac8a5d226e2de8b711
https://doi.org/10.1083/jcb.200104008
https://doi.org/10.1083/jcb.200104008
Publikováno v:
Journal of Biological Chemistry. 272:24125-24128
The Fas antigen (CD95, APO-1) is a transmembrane cell surface receptor that mediates apoptosis of many cell types when bound by Fas ligand or cross-linked by agonist antibody. The cellular factors regulating Fas-induced apoptosis have not been well d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a372660044fadbbc908cfcf39581459a
https://doi.org/10.1074/jbc.272.39.24125
https://doi.org/10.1074/jbc.272.39.24125