IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators

Autor: Olivia Joan Adams, Valentin Djonov, Marius Lötscher, Thomas Kaufmann, Christoph Schneider, Christoph Mueller, Fritz Daudel, Stephan von Gunten, Marc Wehrli, Christian Münz, Ruslan Hlushchuk, Kayluz Frias Boligan, Daniëlle Verschoor, Peter M. Villiger, Cédric Vonarburg, Frank Seibold, Hans-Uwe Simon, Nikhil Yawalkar, Fabiola Cortinas-Elizondo, Sylvia Miescher, Christine Engelmann

Publikováno v: The Journal of Immunology. 205:2640-2648

IVIG preparations consisting of pooled IgG are increasingly used for the treatment of autoimmune diseases. IVIG is known to regulate the viability of immune cells, including neutrophils. We report that plasma-derived IgA efficiently triggers death of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411ba144ad514f51c02e3eefa85206f2
https://doi.org/10.4049/jimmunol.1900883

Human IgA binds a diverse array of commensal bacteria

Autor: Martin R. Larsen, Asok Rajkumar, Carmen Capito, Hela El-Kafsi, Hans Yssel, Guy Gorochov, Delphine Sterlin, Olivia Joan Adams, Catherine Juste, Thomas Candela, Jean-Luc Charuel, Christophe Parizot, Karim Dorgham, Friederike Jönsson, Hedda Wardemann, Hélène Brisson, Stephan von Gunten, Richard D. Cummings, Gaëlle Autaa, Claire Fieschi, Alexandra Aubry, Christophe Trésallet, Jehane Fadlallah

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (3), pp.e20181635. ⟨10.1084/jem.20181635⟩
Journal of Experimental Medicine, 2020, 217 (3), pp.e20181635. ⟨10.1084/jem.20181635⟩
Sterlin, Delphine; Fadlallah, Jehane; Adams, Olivia; Fieschi, Claire; Parizot, Christophe; Dorgham, Karim; Rajkumar, Asok; Autaa, Gaëlle; El-Kafsi, Hela; Charuel, Jean-Luc; Juste, Catherine; Jönsson, Friederike; Candela, Thomas; Wardemann, Hedda; Aubry, Alexandra; Capito, Carmen; Brisson, Hélène; Tresallet, Christophe; Cummings, Richard D; Larsen, Martin; ... (2020). Human IgA binds a diverse array of commensal bacteria. Journal of experimental medicine, 217(3) Rockefeller University Press 10.1084/jem.20181635
The Journal of Experimental Medicine

Intestinal IgA is a key player in host-commensal symbiosis. Sterlin et al. report that human IgAs are microbiota cross-reactive at the clonal level. IgA1 and IgA2 mostly converge toward common gut microbiota targets but possess distinct carbohydrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549abdf15c08d2fad43b1bb61ff6d2f3
https://hal.sorbonne-universite.fr/hal-02433421/document

Medications Used for the Cardiovascular System

Autor: Joan Adams, Ehsan Khan

Publikováno v: Understanding Pharmacology in Nursing Practice ISBN: 9783030320034

This chapter examines the commonly prescribed medications used for the treatment and management of four cardiovascular disorders. The drugs reviewed include organic nitrates, calcium-channel blockers, angiotensin-converting enzyme inhibitors, angiote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08acfb7b4d0e3a3c1d4eb08560eb255f
https://doi.org/10.1007/978-3-030-32004-1_7

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

Autor: Bastian Dislich, Dino Kröll, Anna M. Schläfli, Christian Seiler, Olivia Joan Adams, Rupert Langer, Sabina Berezowska, Mario P. Tschan

Publikováno v: Oncotarget
Adams, Olivia Joan; Dislich, Bastian; Berezowska, Sabina Anna; Schläfli, Anna; Seiler, Christian A.; Kröll, Dino; Tschan, Mario; Langer, Rupert (2016). Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. OncoTarget, 7(26), pp. 39241-39255. Impact Journals LLC 10.18632/oncotarget.9649

Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13679673b698ebb3d44281baa16c003
http://europepmc.org/articles/PMC5129929

A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas

Autor: Bastian Dislich, Olivia Joan Adams, Mario P. Tschan, Magali Humbert, Rupert Langer, Julia Slotta-Huspenina, Christian Seiler, Dino Kröll, Katja Ott, Sabina Berezowska, Félice A. Janser, Marcus Feith

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0224832 (2019)
PLoS ONE
Adams, Olivia; Janser, Félice A.; Dislich, Bastian; Berezowska, Sabina; Humbert, Magali; Seiler, Christian A.; Kröll, Dino; Slotta-Huspenina, Julia; Feith, Marcus; Ott, Katja; Tschan, Mario P.; Langer, Rupert (2019). Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS ONE, 14(10), e0224832. Public Library of Science 10.1371/journal.pone.0224832

Paclitaxel is a powerful chemotherapeutic drug, used for the treatment of many cancer types, including esophageal adenocarcinomas (EAC). Autophagy is a lysosome-dependent degradation process maintaining cellular homeostasis. Defective autophagy has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db732443bd62d1d4df9e7777e86fb078
https://doi.org/10.1371/journal.pone.0224832