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Airway oscillometry after single lung transplantation is characterised by abnormal respiratory reactance

Autor: Marshall Plit, Brigitte M. Borg, Bronwyn Levvey, D.R. Darley, Kristopher Nilsen, Joan P.Y. Sim Sim, Katrina O. Tonga, Gregory I Snell, Riva Shirol, Jaideep Vazirani

Publikováno v: Transplantation.

Aim: Single (SLTx) and double lung transplantation (DLTx) are therapeutic options for end-stage interstitial lung disease (ILD). The aim of this study is to describe oscillometry indices in stable SLTx compared to DLTx recipients. Methods: Oscillomet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::037737c2a2918139489805a5bd1421a4
https://doi.org/10.1183/13993003.congress-2021.pa3497

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A catalogue of tools and variables from crisis and routine care to support decision-making about allocation of intensive care beds and ventilator treatment during pandemics: Scoping review

Autor: Alex Psirides, Rebecca Nguyen, Joan Py Sim, Magnolia Cardona, Claudia C. Dobler, Justin Clark, Eyza Koreshe, Daren K. Heyland

Publikováno v: Journal of critical care. 66

Purpose This scoping review sought to identify objective factors to assist clinicians and policy-makers in making consistent, objective and ethically sound decisions about resource allocation when healthcare rationing is inevitable. Materials and met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f2d7550ff57e2201f3f0c8c4513482
https://pubmed.ncbi.nlm.nih.gov/34438132

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Purinergic and Store-Operated Ca2+ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration

Autor: Lin-Hua Jiang, Fatema Mousawi, Xuebin Yang, Joan A. Sim, Yunjie Hao, Jing Li, Sébastien Roger, Hongsen Peng, Sreenivasan Ponnambalam

Publikováno v: Stem Cells. 34:2102-2114

ATP is an extrinsic signal that can induce an increase in the cytosolic Ca2+ level ([Ca2+]c) in mesenchymal stem cells (MSCs). However, the cognate intrinsic mechanisms underlying ATP-induced Ca2+ signaling in MSCs is still contentious, and their imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddcd12273f5f4bdcaa1f1587b95265c
https://doi.org/10.1002/stem.2370

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A critical role of TRPM2 channel in Aβ42-induced microglial activation and generation of tumor necrosis factor-α

Autor: Veronika E. Neubrand, Sharifah Alawieyah Syed Mortadza, Lin-Hua Jiang, Joan A. Sim

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Amyloid β (Aβ)-induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor potential melastatin-related 2 (TRPM2) channel in Aβ-induced neuroinflammation, but how Aβ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d6b6bbdeafc5d92e809178e68b7c6f
http://hdl.handle.net/10261/216932

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A critical role of TRPM2 channel in Aβ

Autor: Sharifah, Alawieyah Syed Mortadza, Joan A, Sim, Veronika E, Neubrand, Lin-Hua, Jiang

Publikováno v: Glia. 66(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c777bf8d9ffa7b8aae15fb875aaf0cc
https://pubmed.ncbi.nlm.nih.gov/29143372

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Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells

Autor: Joan A. Sim, Sharifah Alawieyah Syed Mortadza, Martin Stacey, Lin-Hua Jiang

Publikováno v: Mortadza, S S, Sim, J A, Stacey, M & Jiang, L H 2017, ' Signalling mechanisms mediating Zn 2+-induced TRPM2 channel activation and cell death in microglial cells ', Scientific Reports, vol. 7, 45032 . https://doi.org/10.1038/srep45032

Excessive Zn2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells. H2O2/Zn2+ induced concentration-dependent increases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e077e2f8b78dd7e5d1dad3f4bea9324a

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Signalling mechanisms mediating Zn

Autor: Sharifah Syed, Mortadza, Joan A, Sim, Martin, Stacey, Lin-Hua, Jiang

Publikováno v: Scientific Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a2144b077ca1cfffba3493f44bc3a37
https://pubmed.ncbi.nlm.nih.gov/28322340

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Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons

Autor: R. Alan North, Andrew W. Baxter, Joan A. Sim, Se Joon Choi

Publikováno v: European Journal of Neuroscience. 34:213-220

P2X4 receptors are calcium-permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We compared features of synaptic strengthening between wild-type and P2X4 knockout mice (21–26 da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::098d1100d333ad2a979773f9e82a5da1
https://doi.org/10.1111/j.1460-9568.2011.07763.x

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Ectodomain Lysines and Suramin Block of P2X1 Receptors*

Autor: R. Alan North, Helen Broomhead, Joan A. Sim

Publikováno v: The Journal of Biological Chemistry

P2X(1) receptors belong to a family of cation channels gated by extracellular ATP; they are found inter alia in smooth muscle, platelets, and immune cells. Suramin has been widely used as an antagonist at P2X receptors, and its analog 4,4',4'',4'''-[

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cac5b807ddb1ba6f3a2486575b7a097
http://europepmc.org/articles/PMC2573084

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Molecular and cellular properties of GnRH neurons revealed through transgenics in the mouse

Autor: Allan E. Herbison, Sharon X. Simonian, Joan A. Sim, Jean-Rémi Pape, Michael J. Skynner

Publikováno v: Molecular and Cellular Endocrinology. 185:185-194

Recent advances in the use of gonadotropin-releasing hormone (GnRH) promoter-driven transgenics in the mouse are beginning to open up the once elusive GnRH neuronal phenotype to detailed molecular and cellular investigation. This review highlights pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b557f1aff07b379985a6a0522d528c
https://doi.org/10.1016/s0303-7207(01)00618-9

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