Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Joan A. Geoghegan"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
S. aureus uses its surface protein SdrE to form catch bonds with the host regulatory protein factor H and evade the human immune system.
Externí odkaz:
https://doaj.org/article/f1f1e00e9efa47f693233554137d31be
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The first step during skin colonization by is its adhesion to corneocytes. Da Costa et al. show that the cell wall-anchored fibronectin binding protein B (FnBPB) of S. aureus binds to loricrin. Applying single cell force spectroscopy, they demonstrat
Externí odkaz:
https://doaj.org/article/aa757c13977344d5bc414bd6147ded68
Autor:
Filippo Prencipe, Aishah Alsibaee, Zainab Khaddem, Padraig Norton, Aisling M. Towell, Afnan F. M. Ali, Gerard Reid, Orla M. Fleury, Timothy J. Foster, Joan A. Geoghegan, Isabel Rozas, Marian P. Brennan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Staphylococcus aureus infections have become a major challenge in health care due to increasing antibiotic resistance. We aimed to design small molecule inhibitors of S. aureus surface proteins to be developed as colonization inhibitors. We
Externí odkaz:
https://doaj.org/article/30ecc30ad9f947c1a59d1c7bd7ddc0d5
Autor:
Samir Olatunji, Xiaoxiao Yu, Jonathan Bailey, Chia-Ying Huang, Marta Zapotoczna, Katherine Bowen, Maja Remškar, Rolf Müller, Eoin M. Scanlan, Joan A. Geoghegan, Vincent Olieric, Martin Caffrey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profou
Externí odkaz:
https://doaj.org/article/01038f4ee14b4c098398c5a500858933
Autor:
Vannakambadi K. Ganesh, Xiaowen Liang, Joan A. Geoghegan, Ana Luisa V. Cohen, Nagarajan Venugopalan, Timothy J Foster, Magnus Hook
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 328-338 (2016)
The Staphylococcus aureus fibrinogen binding MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules), ClfA (clumping factor A) is an important virulence factor in staphylococcal infections and a component of several vaccines curr
Externí odkaz:
https://doaj.org/article/380b36604cbc44f9a5060758947deaff
Autor:
Marta Zapotoczna, Gustavo P. Riboldi, Ahmed M. Moustafa, Elizabeth Dickson, Apurva Narechania, Julie A. Morrissey, Paul J. Planet, Matthew T. G. Holden, Kevin J. Waldron, Joan A. Geoghegan
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Pathogens are exposed to toxic levels of copper during infection, and copper tolerance may be a general virulence mechanism used by bacteria to resist host defenses. In support of this, inactivation of copper exporter genes has been found to
Externí odkaz:
https://doaj.org/article/2bf73d0d0ecc4842a392be8e865a0c11
Autor:
Cécile Feuillie, Pauline Vitry, Maeve A. McAleer, Sanja Kezic, Alan D. Irvine, Joan A. Geoghegan, Yves F. Dufrêne
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT The bacterial pathogen Staphylococcus aureus plays an important role in atopic dermatitis (AD), a chronic disorder that mostly affects children. Colonization of the skin of AD patients by S. aureus exacerbates the disease, but the molecular
Externí odkaz:
https://doaj.org/article/13aa218c61aa432cb0bd7b02a0d13608
Autor:
Pauline Vitry, Claire Valotteau, Cécile Feuillie, Simon Bernard, David Alsteens, Joan A. Geoghegan, Yves F. Dufrêne
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Bacterial pathogens that colonize host surfaces are subjected to physical stresses such as fluid flow and cell surface contacts. How bacteria respond to such mechanical cues is an important yet poorly understood issue. Staphylococcus aureus
Externí odkaz:
https://doaj.org/article/dd2ed11d1e2847eb979c775c523b0726
Autor:
Philippe Herman-Bausier, Sofiane El-Kirat-Chatel, Timothy J. Foster, Joan A. Geoghegan, Yves F. Dufrêne
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Staphylococcus aureus is an important opportunistic pathogen which is a leading cause of biofilm-associated infections on indwelling medical devices. The cell surface-located fibronectin-binding protein A (FnBPA) plays an important role in t
Externí odkaz:
https://doaj.org/article/bf10fdb98e854f7299159ad516c6c57b
Autor:
Paul J. Planet, Samuel J. LaRussa, Ali Dana, Hannah Smith, Amy Xu, Chanelle Ryan, Anne-Catrin Uhlemann, Sam Boundy, Julia Goldberg, Apurva Narechania, Ritwij Kulkarni, Adam J. Ratner, Joan A. Geoghegan, Sergios-Orestis Kolokotronis, Alice Prince
Publikováno v:
mBio, Vol 4, Iss 6 (2013)
ABSTRACT The arginine catabolic mobile element (ACME) is the largest genomic region distinguishing epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other S. aureus strains. However, the functional relevance of ACME t
Externí odkaz:
https://doaj.org/article/23678e48e8fd4f5397c09784e28a48a2