Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Joan A Lenihan"'
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187352 (2017)
Ligand of Numb protein X1 (LNX1) is an E3 ubiquitin ligase that contains a catalytic RING (Really Interesting New Gene) domain and four PDZ (PSD-95, DlgA, ZO-1) domains. LNX1 can ubiquitinate Numb, as well as a number of other ligands. However, the p
Externí odkaz:
https://doaj.org/article/5097463fdc094bb0869ca7bac7e18441
Publikováno v:
Gene. 552:39-50
LNX1 and LNX2 are E3 ubiquitin ligases that can interact with Numb - a key regulator of neurogenesis and neuronal differentiation. LNX1 can target Numb for proteasomal degradation, and Lnx mRNAs are prominently expressed in the nervous system, sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551b60be325e4d4117f71ea0c8f51c8c
https://doi.org/10.1016/j.gene.2014.09.011
https://doi.org/10.1016/j.gene.2014.09.011
Autor:
Victoria Heimer-McGinn, Orthis Saha, Paul Young, Joan A. Lenihan, Guoping Feng, John F. Cryan
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b10b844b06642ef0a07cdff865564a
https://hdl.handle.net/10468/3505
https://hdl.handle.net/10468/3505
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187352 (2017)
PLoS ONE, Vol 12, Iss 11, p e0187352 (2017)
Ligand of Numb protein X1 (LNX1) is an E3 ubiquitin ligase that contains a catalytic RING (Really Interesting New Gene) domain and four PDZ (PSD-95, DlgA, ZO-1) domains. LNX1 can ubiquitinate Numb, as well as a number of other ligands. However, the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be63dc128d40990c7f5a88a666083f23
https://doi.org/10.1371/journal.pone.0187352
https://doi.org/10.1371/journal.pone.0187352